ID   T30A2_RAT               Reviewed;         664 AA.
AC   Q4QQS2;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Tetratricopeptide repeat protein 30A2;
DE            Short=TPR repeat protein 30A2;
GN   Name=Ttc30a2; Synonyms=Ttc30a1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Required for polyglutamylation of axonemal tubulin. Plays a
CC       role in anterograde intraflagellar transport (IFT), the process by
CC       which cilia precursors are transported from the base of the cilium to
CC       the site of their incorporation at the tip. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts wit the IFT B complex component IFT52.
CC       {ECO:0000250|UniProtKB:A2AKQ8}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TTC30/dfy-1/fleer family. {ECO:0000305}.
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DR   EMBL; BC098051; AAH98051.1; -; mRNA.
DR   RefSeq; NP_001025089.1; NM_001029918.1.
DR   AlphaFoldDB; Q4QQS2; -.
DR   SMR; Q4QQS2; -.
DR   STRING; 10116.ENSRNOP00000013565; -.
DR   PhosphoSitePlus; Q4QQS2; -.
DR   PaxDb; Q4QQS2; -.
DR   Ensembl; ENSRNOT00000013565; ENSRNOP00000013565; ENSRNOG00000052519.
DR   GeneID; 311123; -.
DR   KEGG; rno:311123; -.
DR   CTD; 78802; -.
DR   RGD; 1560121; Ttc30a1.
DR   eggNOG; KOG4340; Eukaryota.
DR   GeneTree; ENSGT00390000010116; -.
DR   HOGENOM; CLU_023760_0_0_1; -.
DR   InParanoid; Q4QQS2; -.
DR   OMA; EYQLRNH; -.
DR   OrthoDB; 247838at2759; -.
DR   TreeFam; TF314592; -.
DR   PRO; PR:Q4QQS2; -.
DR   Proteomes; UP000002494; Chromosome 3.
DR   Bgee; ENSRNOG00000052519; Expressed in testis and 18 other tissues.
DR   Genevisible; Q4QQS2; RN.
DR   GO; GO:0005879; C:axonemal microtubule; IBA:GO_Central.
DR   GO; GO:0005813; C:centrosome; ISO:RGD.
DR   GO; GO:0005929; C:cilium; ISO:RGD.
DR   GO; GO:0030992; C:intraciliary transport particle B; ISO:RGD.
DR   GO; GO:0120170; F:intraciliary transport particle B binding; ISO:RGD.
DR   GO; GO:0042073; P:intraciliary transport; IBA:GO_Central.
DR   Gene3D; 1.25.40.10; -; 2.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   InterPro; IPR039941; TT30.
DR   PANTHER; PTHR20931; PTHR20931; 1.
DR   Pfam; PF13176; TPR_7; 1.
DR   SMART; SM00028; TPR; 4.
DR   SUPFAM; SSF48452; SSF48452; 2.
DR   PROSITE; PS50293; TPR_REGION; 3.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Cilium biogenesis/degradation; Coiled coil;
KW   Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..664
FT                   /note="Tetratricopeptide repeat protein 30A2"
FT                   /id="PRO_0000333205"
FT   REPEAT          11..44
FT                   /note="TPR 1"
FT   REPEAT          45..78
FT                   /note="TPR 2"
FT   REPEAT          153..186
FT                   /note="TPR 3"
FT   REPEAT          188..220
FT                   /note="TPR 4"
FT   REPEAT          395..423
FT                   /note="TPR 5"
FT   REPEAT          424..456
FT                   /note="TPR 6"
FT   REPEAT          458..491
FT                   /note="TPR 7"
FT   REPEAT          543..576
FT                   /note="TPR 8"
FT   COILED          507..534
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   664 AA;  76065 MW;  C7C17A957249F190 CRC64;
     MAGLSSSQIP DGEFTAVVYR LIRDSRYSEA VQLLSAELQR SPRSRAGLSL LAYCYYRLQE
     FELAAECYEQ LSQMHPELEQ YRLYQAQALY KACLYPEATR VAFLLDNPSF YSRVLRLQAA
     IKYSEGDLPG ARSLVEQLLS GEAGEDSGGE NDPDGLVNMG CLLYKEGHYE AACSKFFAAL
     QASGYQPDVS YNLALACYSN RHYAPALKHI ANIIERGIRQ HPELGVGMTT EGIDVRSVGN
     TVVLHQTALV EAFNLKAAIE YQLRNFEAAQ EALTDMPPRA EEELDPVTLH NQALMNMDAK
     PTEGFEKLQF LLQQNPFPPE TFGNLLLLYC KYEYFDLAAD VLAENAHLTY KFLTPYLYDF
     LDAMITCQTA PEEAFIKLDG LAGMLTEQLR RLTKQVQEAR HNRDDEVVIK AVNEYDETLE
     KYIPVLMAQA KIYWNLENYQ MVEKIFRKSV EFCNDHDVWK LNVAHVLFMQ ENKYKEAIGF
     YEPIVKKNYD NILSVSAIVL ANLCVSYIMT SQNEEAEELM RKIEKEEEQL SYGDPDKKIY
     HLCIVNLVIG TLYCAKGNYD FGISRVIKSL EPYHKKLGTD TWYYAKRCFL SLLENMSKHT
     IMLRDSVIQE CVQFLEHCEI FGRSIPAVIE QPLEEERMHT GKNTVTYESR QLKALIYEII
     GWNM