T41AB_DANRE
ID T41AB_DANRE Reviewed; 278 AA.
AC Q6NV38; Q1LY83;
DT 07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Transmembrane protein 41A-B {ECO:0000312|EMBL:AAH68328.1};
DE Flags: Precursor;
GN Name=tmem41ab {ECO:0000312|ZFIN:ZDB-GENE-040426-2050};
GN ORFNames=si:dkey-22o12.1, si:dkey-24b15.3, zgc:85616;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1] {ECO:0000312|EMBL:AAH68328.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney {ECO:0000312|EMBL:AAH68328.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the TMEM41 family. {ECO:0000255}.
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DR EMBL; BC068328; AAH68328.1; -; mRNA.
DR EMBL; BX088533; CAK10812.1; -; Genomic_DNA.
DR EMBL; CR382370; CAQ13888.1; -; Genomic_DNA.
DR RefSeq; NP_998248.1; NM_213083.1.
DR AlphaFoldDB; Q6NV38; -.
DR STRING; 7955.ENSDARP00000039201; -.
DR PaxDb; Q6NV38; -.
DR Ensembl; ENSDART00000033024; ENSDARP00000039201; ENSDARG00000026771.
DR GeneID; 406356; -.
DR KEGG; dre:406356; -.
DR CTD; 406356; -.
DR ZFIN; ZDB-GENE-040426-2050; tmem41ab.
DR eggNOG; KOG3140; Eukaryota.
DR GeneTree; ENSGT00940000162528; -.
DR HOGENOM; CLU_038944_0_2_1; -.
DR InParanoid; Q6NV38; -.
DR OMA; ERQHRGA; -.
DR OrthoDB; 1222755at2759; -.
DR PhylomeDB; Q6NV38; -.
DR TreeFam; TF314301; -.
DR PRO; PR:Q6NV38; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 1.
DR Bgee; ENSDARG00000026771; Expressed in muscle tissue and 8 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR032816; SNARE_assoc.
DR InterPro; IPR045014; TM41A/B.
DR PANTHER; PTHR43220; PTHR43220; 1.
DR Pfam; PF09335; SNARE_assoc; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..278
FT /note="Transmembrane protein 41A-B"
FT /evidence="ECO:0000255"
FT /id="PRO_0000378620"
FT TRANSMEM 78..98
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 164..184
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 191..211
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 230..250
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 231
FT /note="F -> S (in Ref. 2; CAK10812)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 278 AA; 31759 MW; 0EB8832D09DD365D CRC64;
MRSIWGLIVL VAAATFYLYL LSAFLPPGPR AIRVHDTGPE HTDDEPEEKV LRLKFPSDLE
ELRELAELLK FYKTEHTGYV FILFCSAYLY KQSFAIPGSS FLNMLSGALF GPLHGLIIAC
TLTTVGSTNC YLLSRTFGKR HIVRLFPEKV AMLQRMVEEN RSSLFFFLLF LRFFPMTPNW
FLNVTSPILN IPIPIFFFSI LIGLIPYNFI CVHTGAVLSE INSLDDIFSW FTLLQLLLIA
CVALLPGALI RRYSKDHLKL HGLEPNGHQK ILNDRKTR
