ID   T431_STAA8              Reviewed;         224 AA.
AC   P0C1L0; P0A046; P19380;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 41.
DE   RecName: Full=Transposase for insertion sequence-like element IS431mec;
GN   Name=tnp;
OS   Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2830163; DOI=10.1016/0378-1119(87)90271-x;
RA   Barberis-Maino L., Berger-Baechi B., Weber H., Beck W.D., Kayser F.H.;
RT   "IS431, a staphylococcal insertion sequence-like element related to IS26
RT   from Proteus vulgaris.";
RL   Gene 59:107-113(1987).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2170938; DOI=10.1093/nar/18.18.5548;
RA   Barberis-Maino L., Ryffel C., Kayser F.H., Berger-Baechi B.;
RT   "Complete nucleotide sequence of IS431mec in Staphylococcus aureus.";
RL   Nucleic Acids Res. 18:5548-5548(1990).
CC   -!- FUNCTION: Involved in the transposition of the insertion sequence.
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DR   EMBL; X53818; CAA37814.1; -; Genomic_DNA.
DR   PIR; S12093; S12093.
DR   AlphaFoldDB; P0C1L0; -.
DR   eggNOG; COG3316; Bacteria.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0032196; P:transposition; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.420.10; -; 1.
DR   InterPro; IPR032874; DDE_dom.
DR   InterPro; IPR001584; Integrase_cat-core.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF13610; DDE_Tnp_IS240; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS50994; INTEGRASE; 1.
PE   4: Predicted;
KW   DNA recombination; DNA-binding; Transposable element; Transposition.
FT   CHAIN           1..224
FT                   /note="Transposase for insertion sequence-like element
FT                   IS431mec"
FT                   /id="PRO_0000244873"
FT   DOMAIN          73..222
FT                   /note="Integrase catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00457"
FT   DNA_BIND        33..52
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   224 AA;  26915 MW;  4A24F3CB0B0B52D2 CRC64;
     MNYFRYKQFN KDVITVAVGY YLRYTLSYRD ISEILRERGV NVHHSTVYRW VQEYAPILYQ
     IWKKKHKKAY YKWRIDETYI KIKGKWSYLY RAIDAEGHTL DIWLRKQRDN HSAYAFIKRL
     IKQFGKPQKV ITDQAPSTKV AMAKVIKAFK LKPDCHCTSK YLNNLIEQDH RHIKVRKTRY
     QSINTAKNTL KGIECIYALY KKNRRSLQIY GFSPCHEISI MLAS