ID   T431_STAAM              Reviewed;         224 AA.
AC   P0A043; P19380; Q932L7;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Transposase for insertion sequence-like element IS431mec;
GN   Name=tnp1; OrderedLocusNames=SAV0027;
GN   and
GN   Name=tnp2; OrderedLocusNames=SAV0036;
OS   Staphylococcus aureus (strain Mu50 / ATCC 700699).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=158878;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mu50 / ATCC 700699;
RX   PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA   Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA   Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA   Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA   Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA   Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA   Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA   Hiramatsu K.;
RT   "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL   Lancet 357:1225-1240(2001).
CC   -!- FUNCTION: Involved in the transposition of the insertion sequence.
CC       {ECO:0000250}.
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DR   EMBL; BA000017; BAB56189.1; -; Genomic_DNA.
DR   EMBL; BA000017; BAB56198.2; -; Genomic_DNA.
DR   RefSeq; WP_001106057.1; NC_002758.2.
DR   AlphaFoldDB; P0A043; -.
DR   PaxDb; P0A043; -.
DR   EnsemblBacteria; BAB56189; BAB56189; SAV0027.
DR   EnsemblBacteria; BAB56198; BAB56198; SAV0036.
DR   GeneID; 58049818; -.
DR   GeneID; 66838366; -.
DR   KEGG; sav:SAV0027; -.
DR   KEGG; sav:SAV0036; -.
DR   HOGENOM; CLU_067322_1_0_9; -.
DR   OMA; EINHRYD; -.
DR   PhylomeDB; P0A043; -.
DR   BioCyc; SAUR158878:SAV_RS00290-MON; -.
DR   BioCyc; SAUR158878:SAV_RS00320-MON; -.
DR   Proteomes; UP000002481; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0032196; P:transposition; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.420.10; -; 1.
DR   InterPro; IPR032874; DDE_dom.
DR   InterPro; IPR001584; Integrase_cat-core.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF13610; DDE_Tnp_IS240; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS50994; INTEGRASE; 1.
PE   3: Inferred from homology;
KW   DNA recombination; DNA-binding; Transposable element; Transposition.
FT   CHAIN           1..224
FT                   /note="Transposase for insertion sequence-like element
FT                   IS431mec"
FT                   /id="PRO_0000075436"
FT   DOMAIN          73..222
FT                   /note="Integrase catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00457"
FT   DNA_BIND        33..52
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   224 AA;  26915 MW;  4A24F3CB0B0B52D2 CRC64;
     MNYFRYKQFN KDVITVAVGY YLRYTLSYRD ISEILRERGV NVHHSTVYRW VQEYAPILYQ
     IWKKKHKKAY YKWRIDETYI KIKGKWSYLY RAIDAEGHTL DIWLRKQRDN HSAYAFIKRL
     IKQFGKPQKV ITDQAPSTKV AMAKVIKAFK LKPDCHCTSK YLNNLIEQDH RHIKVRKTRY
     QSINTAKNTL KGIECIYALY KKNRRSLQIY GFSPCHEISI MLAS