ID   T431_STAAN              Reviewed;         224 AA.
AC   P0A044; P0A046; P19380;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Transposase for insertion sequence-like element IS431mec;
GN   Name=tnp1; OrderedLocusNames=SA0026;
GN   and
GN   Name=tnp2; OrderedLocusNames=SA0034;
OS   Staphylococcus aureus (strain N315).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=158879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10348769; DOI=10.1128/aac.43.6.1449;
RA   Ito T., Katayama Y., Hiramatsu K.;
RT   "Cloning and nucleotide sequence determination of the entire mec DNA of
RT   pre-methicillin-resistant Staphylococcus aureus N315.";
RL   Antimicrob. Agents Chemother. 43:1449-1458(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=N315;
RX   PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA   Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA   Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA   Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA   Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA   Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA   Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA   Hiramatsu K.;
RT   "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL   Lancet 357:1225-1240(2001).
CC   -!- FUNCTION: Involved in the transposition of the insertion sequence.
CC       {ECO:0000250}.
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DR   EMBL; D86934; BAA82228.1; -; Genomic_DNA.
DR   EMBL; BA000018; BAB41243.1; -; Genomic_DNA.
DR   EMBL; BA000018; BAB41252.1; -; Genomic_DNA.
DR   PIR; S12093; S12093.
DR   RefSeq; WP_001106057.1; NC_002745.2.
DR   AlphaFoldDB; P0A044; -.
DR   EnsemblBacteria; BAB41243; BAB41243; BAB41243.
DR   EnsemblBacteria; BAB41252; BAB41252; BAB41252.
DR   GeneID; 58049818; -.
DR   GeneID; 66838366; -.
DR   KEGG; sau:SA0026; -.
DR   KEGG; sau:SA0034; -.
DR   HOGENOM; CLU_067322_1_0_9; -.
DR   OMA; EINHRYD; -.
DR   Proteomes; UP000000751; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0032196; P:transposition; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.420.10; -; 1.
DR   InterPro; IPR032874; DDE_dom.
DR   InterPro; IPR001584; Integrase_cat-core.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF13610; DDE_Tnp_IS240; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS50994; INTEGRASE; 1.
PE   3: Inferred from homology;
KW   DNA recombination; DNA-binding; Transposable element; Transposition.
FT   CHAIN           1..224
FT                   /note="Transposase for insertion sequence-like element
FT                   IS431mec"
FT                   /id="PRO_0000075437"
FT   DOMAIN          73..222
FT                   /note="Integrase catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00457"
FT   DNA_BIND        33..52
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   224 AA;  26915 MW;  4A24F3CB0B0B52D2 CRC64;
     MNYFRYKQFN KDVITVAVGY YLRYTLSYRD ISEILRERGV NVHHSTVYRW VQEYAPILYQ
     IWKKKHKKAY YKWRIDETYI KIKGKWSYLY RAIDAEGHTL DIWLRKQRDN HSAYAFIKRL
     IKQFGKPQKV ITDQAPSTKV AMAKVIKAFK LKPDCHCTSK YLNNLIEQDH RHIKVRKTRY
     QSINTAKNTL KGIECIYALY KKNRRSLQIY GFSPCHEISI MLAS