ID   T431_STAAW              Reviewed;         224 AA.
AC   P0A045; P19380;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Transposase for insertion sequence-like element IS431mec;
GN   Name=tnp; OrderedLocusNames=MW0027;
OS   Staphylococcus aureus (strain MW2).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=196620;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MW2;
RX   PubMed=12044378; DOI=10.1016/s0140-6736(02)08713-5;
RA   Baba T., Takeuchi F., Kuroda M., Yuzawa H., Aoki K., Oguchi A., Nagai Y.,
RA   Iwama N., Asano K., Naimi T., Kuroda H., Cui L., Yamamoto K., Hiramatsu K.;
RT   "Genome and virulence determinants of high virulence community-acquired
RT   MRSA.";
RL   Lancet 359:1819-1827(2002).
CC   -!- FUNCTION: Involved in the transposition of the insertion sequence.
CC       {ECO:0000250}.
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DR   EMBL; BA000033; BAB93892.1; -; Genomic_DNA.
DR   RefSeq; WP_001106057.1; NC_003923.1.
DR   AlphaFoldDB; P0A045; -.
DR   EnsemblBacteria; BAB93892; BAB93892; BAB93892.
DR   GeneID; 66838366; -.
DR   KEGG; sam:MW0027; -.
DR   HOGENOM; CLU_067322_1_0_9; -.
DR   OMA; EINHRYD; -.
DR   Proteomes; UP000000418; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0032196; P:transposition; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.420.10; -; 1.
DR   InterPro; IPR032874; DDE_dom.
DR   InterPro; IPR001584; Integrase_cat-core.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF13610; DDE_Tnp_IS240; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS50994; INTEGRASE; 1.
PE   3: Inferred from homology;
KW   DNA recombination; DNA-binding; Transposable element; Transposition.
FT   CHAIN           1..224
FT                   /note="Transposase for insertion sequence-like element
FT                   IS431mec"
FT                   /id="PRO_0000075438"
FT   DOMAIN          73..222
FT                   /note="Integrase catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00457"
FT   DNA_BIND        33..52
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   224 AA;  26915 MW;  4A24F3CB0B0B52D2 CRC64;
     MNYFRYKQFN KDVITVAVGY YLRYTLSYRD ISEILRERGV NVHHSTVYRW VQEYAPILYQ
     IWKKKHKKAY YKWRIDETYI KIKGKWSYLY RAIDAEGHTL DIWLRKQRDN HSAYAFIKRL
     IKQFGKPQKV ITDQAPSTKV AMAKVIKAFK LKPDCHCTSK YLNNLIEQDH RHIKVRKTRY
     QSINTAKNTL KGIECIYALY KKNRRSLQIY GFSPCHEISI MLAS