T4S18_HUMAN
ID T4S18_HUMAN Reviewed; 201 AA.
AC Q96CE8; B2R8K0; D3DNH5;
DT 21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Transmembrane 4 L6 family member 18;
GN Name=TM4SF18;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q96CE8; Q12983: BNIP3; NbExp=3; IntAct=EBI-13351685, EBI-749464;
CC Q96CE8; Q8N6F1-2: CLDN19; NbExp=3; IntAct=EBI-13351685, EBI-12256978;
CC Q96CE8; Q9UHP7-3: CLEC2D; NbExp=3; IntAct=EBI-13351685, EBI-11749983;
CC Q96CE8; Q07325: CXCL9; NbExp=3; IntAct=EBI-13351685, EBI-3911467;
CC Q96CE8; P49447: CYB561; NbExp=3; IntAct=EBI-13351685, EBI-8646596;
CC Q96CE8; Q8NBI2: CYB561A3; NbExp=3; IntAct=EBI-13351685, EBI-10269179;
CC Q96CE8; P52803: EFNA5; NbExp=3; IntAct=EBI-13351685, EBI-1753674;
CC Q96CE8; P54852: EMP3; NbExp=3; IntAct=EBI-13351685, EBI-3907816;
CC Q96CE8; Q92520: FAM3C; NbExp=3; IntAct=EBI-13351685, EBI-2876774;
CC Q96CE8; Q9H0Q3: FXYD6; NbExp=3; IntAct=EBI-13351685, EBI-713304;
CC Q96CE8; Q96F15: GIMAP5; NbExp=3; IntAct=EBI-13351685, EBI-6166686;
CC Q96CE8; Q9Y5U9: IER3IP1; NbExp=3; IntAct=EBI-13351685, EBI-725665;
CC Q96CE8; P05107: ITGB2; NbExp=3; IntAct=EBI-13351685, EBI-300173;
CC Q96CE8; O43561-2: LAT; NbExp=3; IntAct=EBI-13351685, EBI-8070286;
CC Q96CE8; Q8TAF8: LHFPL5; NbExp=3; IntAct=EBI-13351685, EBI-2820517;
CC Q96CE8; P21145: MAL; NbExp=3; IntAct=EBI-13351685, EBI-3932027;
CC Q96CE8; P30301: MIP; NbExp=3; IntAct=EBI-13351685, EBI-8449636;
CC Q96CE8; Q5J8X5: MS4A13; NbExp=3; IntAct=EBI-13351685, EBI-12070086;
CC Q96CE8; Q96HJ5: MS4A3; NbExp=3; IntAct=EBI-13351685, EBI-12806656;
CC Q96CE8; Q0D2K0: NIPAL4; NbExp=3; IntAct=EBI-13351685, EBI-9550165;
CC Q96CE8; P42857: NSG1; NbExp=3; IntAct=EBI-13351685, EBI-6380741;
CC Q96CE8; Q01453: PMP22; NbExp=3; IntAct=EBI-13351685, EBI-2845982;
CC Q96CE8; Q9NS64: RPRM; NbExp=3; IntAct=EBI-13351685, EBI-1052363;
CC Q96CE8; Q8N6R1: SERP2; NbExp=3; IntAct=EBI-13351685, EBI-749270;
CC Q96CE8; Q9BRI3: SLC30A2; NbExp=3; IntAct=EBI-13351685, EBI-8644112;
CC Q96CE8; Q9NUM3: SLC39A9; NbExp=3; IntAct=EBI-13351685, EBI-2823239;
CC Q96CE8; Q9BZL3: SMIM3; NbExp=3; IntAct=EBI-13351685, EBI-741850;
CC Q96CE8; P0DN84: STRIT1; NbExp=3; IntAct=EBI-13351685, EBI-12200293;
CC Q96CE8; Q9Y6I9: TEX264; NbExp=3; IntAct=EBI-13351685, EBI-10329860;
CC Q96CE8; A2RU14: TMEM218; NbExp=3; IntAct=EBI-13351685, EBI-10173151;
CC Q96CE8; Q9NSU2-1: TREX1; NbExp=3; IntAct=EBI-13351685, EBI-16746122;
CC Q96CE8; A5PKU2: TUSC5; NbExp=3; IntAct=EBI-13351685, EBI-11988865;
CC Q96CE8; Q9Y385: UBE2J1; NbExp=3; IntAct=EBI-13351685, EBI-988826;
CC Q96CE8; Q9H1C4: UNC93B1; NbExp=3; IntAct=EBI-13351685, EBI-4401271;
CC Q96CE8; O95183: VAMP5; NbExp=3; IntAct=EBI-13351685, EBI-10191195;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the L6 tetraspanin family. {ECO:0000305}.
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DR EMBL; AK313400; BAG36197.1; -; mRNA.
DR EMBL; CH471052; EAW78877.1; -; Genomic_DNA.
DR EMBL; CH471052; EAW78878.1; -; Genomic_DNA.
DR EMBL; CH471052; EAW78879.1; -; Genomic_DNA.
DR EMBL; BC014339; AAH14339.1; -; mRNA.
DR CCDS; CCDS3142.1; -.
DR RefSeq; NP_001171652.1; NM_001184723.1.
DR RefSeq; NP_620141.1; NM_138786.3.
DR AlphaFoldDB; Q96CE8; -.
DR BioGRID; 125506; 51.
DR IntAct; Q96CE8; 41.
DR STRING; 9606.ENSP00000296059; -.
DR TCDB; 8.A.75.1.2; the transmembrane 4 l6 (tm4l6) family.
DR iPTMnet; Q96CE8; -.
DR PhosphoSitePlus; Q96CE8; -.
DR BioMuta; TM4SF18; -.
DR DMDM; 68053312; -.
DR jPOST; Q96CE8; -.
DR MassIVE; Q96CE8; -.
DR PaxDb; Q96CE8; -.
DR PeptideAtlas; Q96CE8; -.
DR PRIDE; Q96CE8; -.
DR ProteomicsDB; 76182; -.
DR Antibodypedia; 67990; 95 antibodies from 18 providers.
DR DNASU; 116441; -.
DR Ensembl; ENST00000296059.7; ENSP00000296059.2; ENSG00000163762.7.
DR Ensembl; ENST00000470080.5; ENSP00000419278.1; ENSG00000163762.7.
DR GeneID; 116441; -.
DR KEGG; hsa:116441; -.
DR MANE-Select; ENST00000296059.7; ENSP00000296059.2; NM_138786.4; NP_620141.1.
DR UCSC; uc003exa.3; human.
DR CTD; 116441; -.
DR DisGeNET; 116441; -.
DR GeneCards; TM4SF18; -.
DR HGNC; HGNC:25181; TM4SF18.
DR HPA; ENSG00000163762; Tissue enhanced (lymphoid).
DR neXtProt; NX_Q96CE8; -.
DR OpenTargets; ENSG00000163762; -.
DR PharmGKB; PA142670801; -.
DR VEuPathDB; HostDB:ENSG00000163762; -.
DR eggNOG; ENOG502QS18; Eukaryota.
DR GeneTree; ENSGT01030000234590; -.
DR InParanoid; Q96CE8; -.
DR OMA; GWEYVFE; -.
DR OrthoDB; 922490at2759; -.
DR PhylomeDB; Q96CE8; -.
DR TreeFam; TF331371; -.
DR PathwayCommons; Q96CE8; -.
DR SignaLink; Q96CE8; -.
DR BioGRID-ORCS; 116441; 9 hits in 1059 CRISPR screens.
DR ChiTaRS; TM4SF18; human.
DR GenomeRNAi; 116441; -.
DR Pharos; Q96CE8; Tbio.
DR PRO; PR:Q96CE8; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q96CE8; protein.
DR Bgee; ENSG00000163762; Expressed in visceral pleura and 156 other tissues.
DR ExpressionAtlas; Q96CE8; baseline and differential.
DR Genevisible; Q96CE8; HS.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR InterPro; IPR008661; L6_membrane.
DR PANTHER; PTHR14198; PTHR14198; 1.
DR Pfam; PF05805; L6_membrane; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..201
FT /note="Transmembrane 4 L6 family member 18"
FT /id="PRO_0000219304"
FT TOPO_DOM 1..9
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 10..30
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 31..49
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 50..70
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 71..93
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..114
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 115..157
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 158..178
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 179..201
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 201 AA; 22277 MW; A49E70402164D336 CRC64;
MGSRKCGGCL SCLLIPLALW SIIVNILLYF PNGQTSYASS NKLTNYVWYF EGICFSGIMM
LIVTTVLLVL ENNNNYKCCQ SENCSKKYVT LLSIIFSSLG IAFSGYCLVI SALGLVQGPY
CRTLDGWEYA FEGTAGRFLT DSSIWIQCLE PAHVVEWNII LFSILITLSG LQVIICLIRV
VMQLSKILCG SYSVIFQPGI I
