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T4S19_HUMAN
ID   T4S19_HUMAN             Reviewed;         209 AA.
AC   Q96DZ7; B2RV20; E9PH22; Q336K7;
DT   21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   24-NOV-2009, sequence version 2.
DT   03-AUG-2022, entry version 135.
DE   RecName: Full=Transmembrane 4 L6 family member 19;
DE   AltName: Full=Osteoclast maturation-associated gene 4 protein;
DE   AltName: Full=Tetraspan membrane protein OCTM4;
GN   Name=TM4SF19; Synonyms=OCTM4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT PRO-8.
RC   TISSUE=Osteoclast;
RA   Yamane S., Toyosaki-Maeda T., Tsuruta Y., Suzuki R., Ochi T.;
RT   "Differential screening of human osteoclast maturation associated genes.";
RL   Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA   Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA   Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA   Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA   Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA   Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA   Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA   Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA   Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA   Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA   Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA   Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA   Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA   Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA   Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA   Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP   PRO-8.
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q96DZ7; O95870: ABHD16A; NbExp=3; IntAct=EBI-6448756, EBI-348517;
CC       Q96DZ7; Q99437: ATP6V0B; NbExp=3; IntAct=EBI-6448756, EBI-3904417;
CC       Q96DZ7; Q12981: BNIP1; NbExp=3; IntAct=EBI-6448756, EBI-4402847;
CC       Q96DZ7; Q8WVX3-2: C4orf3; NbExp=3; IntAct=EBI-6448756, EBI-12003442;
CC       Q96DZ7; Q9P0B6: CCDC167; NbExp=3; IntAct=EBI-6448756, EBI-9083477;
CC       Q96DZ7; P11912: CD79A; NbExp=3; IntAct=EBI-6448756, EBI-7797864;
CC       Q96DZ7; Q4LDR2: CTXN3; NbExp=3; IntAct=EBI-6448756, EBI-12019274;
CC       Q96DZ7; Q9BQA9: CYBC1; NbExp=3; IntAct=EBI-6448756, EBI-2680384;
CC       Q96DZ7; P78329: CYP4F2; NbExp=3; IntAct=EBI-6448756, EBI-1752413;
CC       Q96DZ7; Q9UKR5: ERG28; NbExp=3; IntAct=EBI-6448756, EBI-711490;
CC       Q96DZ7; O00258: GET1; NbExp=3; IntAct=EBI-6448756, EBI-18908258;
CC       Q96DZ7; Q8WWP7: GIMAP1; NbExp=3; IntAct=EBI-6448756, EBI-11991950;
CC       Q96DZ7; Q96F15: GIMAP5; NbExp=3; IntAct=EBI-6448756, EBI-6166686;
CC       Q96DZ7; O14653: GOSR2; NbExp=3; IntAct=EBI-6448756, EBI-4401517;
CC       Q96DZ7; Q8TDT2: GPR152; NbExp=3; IntAct=EBI-6448756, EBI-13345167;
CC       Q96DZ7; P09601: HMOX1; NbExp=3; IntAct=EBI-6448756, EBI-2806151;
CC       Q96DZ7; O95167: NDUFA3; NbExp=3; IntAct=EBI-6448756, EBI-1246131;
CC       Q96DZ7; Q8N912: NRAC; NbExp=3; IntAct=EBI-6448756, EBI-12051377;
CC       Q96DZ7; Q04941: PLP2; NbExp=3; IntAct=EBI-6448756, EBI-608347;
CC       Q96DZ7; Q01453: PMP22; NbExp=3; IntAct=EBI-6448756, EBI-2845982;
CC       Q96DZ7; O75396: SEC22B; NbExp=3; IntAct=EBI-6448756, EBI-1058865;
CC       Q96DZ7; Q8N6R1: SERP2; NbExp=3; IntAct=EBI-6448756, EBI-749270;
CC       Q96DZ7; B2RUZ4: SMIM1; NbExp=3; IntAct=EBI-6448756, EBI-12188413;
CC       Q96DZ7; O15400: STX7; NbExp=3; IntAct=EBI-6448756, EBI-3221827;
CC       Q96DZ7; Q8N2H4: SYS1; NbExp=3; IntAct=EBI-6448756, EBI-13075176;
CC       Q96DZ7; Q9NRX6: TMEM167B; NbExp=3; IntAct=EBI-6448756, EBI-17684533;
CC       Q96DZ7; Q7Z7N9: TMEM179B; NbExp=3; IntAct=EBI-6448756, EBI-11724423;
CC       Q96DZ7; Q96Q45-2: TMEM237; NbExp=3; IntAct=EBI-6448756, EBI-10982110;
CC       Q96DZ7; Q69YG0: TMEM42; NbExp=3; IntAct=EBI-6448756, EBI-12038591;
CC       Q96DZ7; A0AVG3: TSNARE1; NbExp=3; IntAct=EBI-6448756, EBI-12003468;
CC       Q96DZ7; Q9Y385: UBE2J1; NbExp=3; IntAct=EBI-6448756, EBI-988826;
CC       Q96DZ7; Q15836: VAMP3; NbExp=3; IntAct=EBI-6448756, EBI-722343;
CC       Q96DZ7; O75379: VAMP4; NbExp=3; IntAct=EBI-6448756, EBI-744953;
CC       Q96DZ7; O95159: ZFPL1; NbExp=3; IntAct=EBI-6448756, EBI-718439;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q96DZ7-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q96DZ7-2; Sequence=VSP_045895;
CC   -!- SIMILARITY: Belongs to the L6 tetraspanin family. {ECO:0000305}.
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DR   EMBL; AF192910; AAQ13824.1; -; mRNA.
DR   EMBL; AC069257; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471191; EAW53661.1; -; Genomic_DNA.
DR   EMBL; BC146985; AAI46986.1; -; mRNA.
DR   EMBL; BC146993; AAI46994.1; -; mRNA.
DR   EMBL; BC147021; AAI47022.1; -; mRNA.
DR   EMBL; CA489370; -; NOT_ANNOTATED_CDS; mRNA.
DR   CCDS; CCDS3316.1; -. [Q96DZ7-1]
DR   CCDS; CCDS56299.1; -. [Q96DZ7-2]
DR   RefSeq; NP_001191827.1; NM_001204898.1. [Q96DZ7-2]
DR   RefSeq; NP_612470.2; NM_138461.3. [Q96DZ7-1]
DR   AlphaFoldDB; Q96DZ7; -.
DR   BioGRID; 125488; 39.
DR   IntAct; Q96DZ7; 40.
DR   STRING; 9606.ENSP00000273695; -.
DR   TCDB; 8.A.75.1.3; the transmembrane 4 l6 (tm4l6) family.
DR   GlyGen; Q96DZ7; 1 site.
DR   iPTMnet; Q96DZ7; -.
DR   PhosphoSitePlus; Q96DZ7; -.
DR   BioMuta; TM4SF19; -.
DR   DMDM; 269849470; -.
DR   MassIVE; Q96DZ7; -.
DR   PaxDb; Q96DZ7; -.
DR   PeptideAtlas; Q96DZ7; -.
DR   PRIDE; Q96DZ7; -.
DR   Antibodypedia; 81508; 2 antibodies from 2 providers.
DR   DNASU; 116211; -.
DR   Ensembl; ENST00000273695.4; ENSP00000273695.4; ENSG00000145107.16. [Q96DZ7-1]
DR   Ensembl; ENST00000454715.5; ENSP00000387728.1; ENSG00000145107.16. [Q96DZ7-2]
DR   GeneID; 116211; -.
DR   KEGG; hsa:116211; -.
DR   MANE-Select; ENST00000273695.4; ENSP00000273695.4; NM_138461.4; NP_612470.2.
DR   UCSC; uc003fwl.3; human. [Q96DZ7-1]
DR   CTD; 116211; -.
DR   DisGeNET; 116211; -.
DR   GeneCards; TM4SF19; -.
DR   HGNC; HGNC:25167; TM4SF19.
DR   HPA; ENSG00000145107; Tissue enhanced (testis).
DR   neXtProt; NX_Q96DZ7; -.
DR   OpenTargets; ENSG00000145107; -.
DR   PharmGKB; PA142670802; -.
DR   VEuPathDB; HostDB:ENSG00000145107; -.
DR   eggNOG; ENOG502S1UJ; Eukaryota.
DR   GeneTree; ENSGT01030000234590; -.
DR   HOGENOM; CLU_087168_0_0_1; -.
DR   InParanoid; Q96DZ7; -.
DR   OMA; DRFLWDS; -.
DR   OrthoDB; 1173342at2759; -.
DR   PhylomeDB; Q96DZ7; -.
DR   TreeFam; TF331371; -.
DR   PathwayCommons; Q96DZ7; -.
DR   SignaLink; Q96DZ7; -.
DR   BioGRID-ORCS; 116211; 9 hits in 1064 CRISPR screens.
DR   GenomeRNAi; 116211; -.
DR   Pharos; Q96DZ7; Tdark.
DR   PRO; PR:Q96DZ7; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   RNAct; Q96DZ7; protein.
DR   Bgee; ENSG00000145107; Expressed in granulocyte and 89 other tissues.
DR   ExpressionAtlas; Q96DZ7; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   InterPro; IPR008661; L6_membrane.
DR   PANTHER; PTHR14198; PTHR14198; 1.
DR   Pfam; PF05805; L6_membrane; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Glycoprotein; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..209
FT                   /note="Transmembrane 4 L6 family member 19"
FT                   /id="PRO_0000219305"
FT   TOPO_DOM        1..16
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        17..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        38..59
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        60..80
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        81..93
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        94..114
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        115..175
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        176..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        197..209
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        133
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         72..97
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_045895"
FT   VARIANT         8
FT                   /note="Q -> P (in dbSNP:rs6785339)"
FT                   /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.1"
FT                   /id="VAR_060546"
FT   VARIANT         162
FT                   /note="V -> I (in dbSNP:rs35643777)"
FT                   /id="VAR_057280"
SQ   SEQUENCE   209 AA;  22433 MW;  A2AD036CEC966690 CRC64;
     MVSSPCTQAS SRTCSRILGL SLGTAALFAA GANVALLLPN WDVTYLLRGL LGRHAMLGTG
     LWGGGLMVLT AAILISLMGW RYGCFSKSGL CRSVLTALLS GGLALLGALI CFVTSGVALK
     DGPFCMFDVS SFNQTQAWKY GYPFKDLHSR NYLYDRSLWN SVCLEPSAAV VWHVSLFSAL
     LCISLLQLLL VVVHVINSLL GLFCSLCEK
 
 
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