T4S1_MESAU
ID T4S1_MESAU Reviewed; 202 AA.
AC P49111;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 25-MAY-2022, entry version 62.
DE RecName: Full=Transmembrane 4 L6 family member 1;
DE AltName: Full=MM3;
DE AltName: Full=Tumor-associated antigen L6 homolog;
GN Name=TM4SF1; Synonyms=TAAL6;
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8654959; DOI=10.1016/0378-1119(95)00716-4;
RA Maruyama M., Kozuka-Hata K., Sakaguchi-Sanai A., Shioda S., Yamaguchi N.,
RA Maruyama K.;
RT "The cDNA cloning of the hamster homologue of the human L6 gene.";
RL Gene 168:273-274(1996).
CC -!- SUBUNIT: Present in high molecular weight complexes in tumor cells.
CC Interacts with SDCBP2 (By similarity). {ECO:0000250|UniProtKB:P30408}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC Note=Colocalizes with SDCBP2 in the apical region of the cell.
CC {ECO:0000250|UniProtKB:P30408}.
CC -!- SIMILARITY: Belongs to the L6 tetraspanin family. {ECO:0000305}.
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DR RefSeq; NP_001268342.1; NM_001281413.1.
DR AlphaFoldDB; P49111; -.
DR STRING; 10036.XP_005077956.1; -.
DR GeneID; 101833523; -.
DR CTD; 4071; -.
DR eggNOG; ENOG502RY7H; Eukaryota.
DR OrthoDB; 922490at2759; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR008661; L6_membrane.
DR PANTHER; PTHR14198; PTHR14198; 1.
DR Pfam; PF05805; L6_membrane; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..202
FT /note="Transmembrane 4 L6 family member 1"
FT /id="PRO_0000219296"
FT TOPO_DOM 1..9
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 10..30
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 31..49
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 50..70
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 71..93
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..114
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 115..161
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 162..182
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 183..202
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 129
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 159
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 202 AA; 22111 MW; 8DA7E3A13F13F31D CRC64;
MCSSKCTRYI GHSLVVFAVL CIVANILLYF PNGETKYAYE DHLSRFVWFF AGIVGGGLLI
LLPAFVFLGL EGEDCCGCWS CENYGKRCTM LSSIMAALIG IAGSGYCVIV AALGLAEGPK
CGDSHGMWNY TFANTDGQYL LDPTTWSKCH EPNNIVEWNV TLFSILLALG GLEFILCLIQ
VINGVLEGMC SYCCSHQQQY DC