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T4S1_MESAU
ID   T4S1_MESAU              Reviewed;         202 AA.
AC   P49111;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Transmembrane 4 L6 family member 1;
DE   AltName: Full=MM3;
DE   AltName: Full=Tumor-associated antigen L6 homolog;
GN   Name=TM4SF1; Synonyms=TAAL6;
OS   Mesocricetus auratus (Golden hamster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Mesocricetus.
OX   NCBI_TaxID=10036;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8654959; DOI=10.1016/0378-1119(95)00716-4;
RA   Maruyama M., Kozuka-Hata K., Sakaguchi-Sanai A., Shioda S., Yamaguchi N.,
RA   Maruyama K.;
RT   "The cDNA cloning of the hamster homologue of the human L6 gene.";
RL   Gene 168:273-274(1996).
CC   -!- SUBUNIT: Present in high molecular weight complexes in tumor cells.
CC       Interacts with SDCBP2 (By similarity). {ECO:0000250|UniProtKB:P30408}.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC       Note=Colocalizes with SDCBP2 in the apical region of the cell.
CC       {ECO:0000250|UniProtKB:P30408}.
CC   -!- SIMILARITY: Belongs to the L6 tetraspanin family. {ECO:0000305}.
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DR   RefSeq; NP_001268342.1; NM_001281413.1.
DR   AlphaFoldDB; P49111; -.
DR   STRING; 10036.XP_005077956.1; -.
DR   GeneID; 101833523; -.
DR   CTD; 4071; -.
DR   eggNOG; ENOG502RY7H; Eukaryota.
DR   OrthoDB; 922490at2759; -.
DR   Proteomes; UP000189706; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR008661; L6_membrane.
DR   PANTHER; PTHR14198; PTHR14198; 1.
DR   Pfam; PF05805; L6_membrane; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..202
FT                   /note="Transmembrane 4 L6 family member 1"
FT                   /id="PRO_0000219296"
FT   TOPO_DOM        1..9
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        10..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        31..49
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        50..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        71..93
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        94..114
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        115..161
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        162..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        183..202
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        129
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        159
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   202 AA;  22111 MW;  8DA7E3A13F13F31D CRC64;
     MCSSKCTRYI GHSLVVFAVL CIVANILLYF PNGETKYAYE DHLSRFVWFF AGIVGGGLLI
     LLPAFVFLGL EGEDCCGCWS CENYGKRCTM LSSIMAALIG IAGSGYCVIV AALGLAEGPK
     CGDSHGMWNY TFANTDGQYL LDPTTWSKCH EPNNIVEWNV TLFSILLALG GLEFILCLIQ
     VINGVLEGMC SYCCSHQQQY DC
 
 
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