T4S1_MOUSE
ID T4S1_MOUSE Reviewed; 202 AA.
AC Q64302; Q3TP49;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Transmembrane 4 L6 family member 1;
DE AltName: Full=Membrane component chromosome 3 surface marker 1 homolog;
DE AltName: Full=Tumor-associated antigen L6;
GN Name=Tm4sf1; Synonyms=M3s1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND TOPOLOGY.
RC STRAIN=BALB/cJ; TISSUE=Thymic epithelium;
RX PubMed=7510285; DOI=10.1016/s0021-9258(17)37298-8;
RA Marken J.S., Bajorath J., Edwards C.P., Farr A.G., Schieven G.L.,
RA Hellstroem I., Hellstroem K.E., Aruffo A.;
RT "Membrane topology of the L6 antigen and identification of the protein
RT epitope recognized by the L6 monoclonal antibody.";
RL J. Biol. Chem. 269:7397-7401(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Kidney, and Pituitary;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Olfactory epithelium;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-142.
RC TISSUE=Myoblast;
RX PubMed=19656770; DOI=10.1074/mcp.m900195-mcp200;
RA Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D.,
RA Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B.;
RT "The mouse C2C12 myoblast cell surface N-linked glycoproteome:
RT identification, glycosite occupancy, and membrane orientation.";
RL Mol. Cell. Proteomics 8:2555-2569(2009).
CC -!- SUBUNIT: Present in high molecular weight complexes in tumor cells.
CC Interacts with SDCBP2 (By similarity). {ECO:0000250|UniProtKB:P30408}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC Note=Colocalizes with SDCBP2 in the apical region of the cell.
CC {ECO:0000250|UniProtKB:P30408}.
CC -!- TISSUE SPECIFICITY: Highly expressed in skin and lung. Moderately
CC expressed in lymph nodes and kidneys. Also present in thymic stroma and
CC fibroblasts. {ECO:0000269|PubMed:7510285}.
CC -!- SIMILARITY: Belongs to the L6 tetraspanin family. {ECO:0000305}.
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DR EMBL; L15443; AAA39403.1; -; mRNA.
DR EMBL; L15429; AAA17873.1; -; mRNA.
DR EMBL; AK077326; BAC36752.1; -; mRNA.
DR EMBL; AK164718; BAE37888.1; -; mRNA.
DR EMBL; BC083073; AAH83073.1; -; mRNA.
DR CCDS; CCDS38433.1; -.
DR PIR; A53399; A53399.
DR RefSeq; NP_032562.1; NM_008536.3.
DR RefSeq; XP_006501143.1; XM_006501080.1.
DR AlphaFoldDB; Q64302; -.
DR BioGRID; 201262; 1.
DR IntAct; Q64302; 2.
DR MINT; Q64302; -.
DR STRING; 10090.ENSMUSP00000130999; -.
DR GlyGen; Q64302; 2 sites.
DR iPTMnet; Q64302; -.
DR PhosphoSitePlus; Q64302; -.
DR PaxDb; Q64302; -.
DR PRIDE; Q64302; -.
DR ProteomicsDB; 263237; -.
DR Antibodypedia; 1003; 280 antibodies from 32 providers.
DR DNASU; 17112; -.
DR Ensembl; ENSMUST00000029376; ENSMUSP00000029376; ENSMUSG00000027800.
DR Ensembl; ENSMUST00000171384; ENSMUSP00000130999; ENSMUSG00000027800.
DR Ensembl; ENSMUST00000196979; ENSMUSP00000143652; ENSMUSG00000027800.
DR GeneID; 17112; -.
DR KEGG; mmu:17112; -.
DR UCSC; uc008pgy.1; mouse.
DR CTD; 4071; -.
DR MGI; MGI:104678; Tm4sf1.
DR VEuPathDB; HostDB:ENSMUSG00000027800; -.
DR eggNOG; ENOG502RY7H; Eukaryota.
DR GeneTree; ENSGT01030000234590; -.
DR InParanoid; Q64302; -.
DR OMA; ICRPCCY; -.
DR OrthoDB; 922490at2759; -.
DR PhylomeDB; Q64302; -.
DR TreeFam; TF331371; -.
DR BioGRID-ORCS; 17112; 0 hits in 73 CRISPR screens.
DR ChiTaRS; Tm4sf1; mouse.
DR PRO; PR:Q64302; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q64302; protein.
DR Bgee; ENSMUSG00000027800; Expressed in aorta tunica media and 212 other tissues.
DR ExpressionAtlas; Q64302; baseline and differential.
DR Genevisible; Q64302; MM.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; ISO:MGI.
DR GO; GO:0001825; P:blastocyst formation; IMP:MGI.
DR InterPro; IPR008661; L6_membrane.
DR PANTHER; PTHR14198; PTHR14198; 1.
DR Pfam; PF05805; L6_membrane; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..202
FT /note="Transmembrane 4 L6 family member 1"
FT /id="PRO_0000219297"
FT TOPO_DOM 1..9
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305|PubMed:7510285"
FT TRANSMEM 10..30
FT /note="Helical"
FT /evidence="ECO:0000305"
FT TOPO_DOM 31..49
FT /note="Extracellular"
FT /evidence="ECO:0000305|PubMed:7510285"
FT TRANSMEM 50..70
FT /note="Helical"
FT /evidence="ECO:0000305"
FT TOPO_DOM 71..93
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305|PubMed:7510285"
FT TRANSMEM 94..114
FT /note="Helical"
FT /evidence="ECO:0000305"
FT TOPO_DOM 115..161
FT /note="Extracellular"
FT /evidence="ECO:0000305|PubMed:7510285"
FT TRANSMEM 162..182
FT /note="Helical"
FT /evidence="ECO:0000305"
FT TOPO_DOM 183..202
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305|PubMed:7510285"
FT CARBOHYD 129
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 142
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:19656770"
SQ SEQUENCE 202 AA; 22243 MW; 93838E707D85FF02 CRC64;
MCYVKCARYI GYSLVWAAVF CIVANALLYF PNGETKYATE DHLSRFVWYF AGIVGGGLLM
LLPAFVFIGM DEEDCCGCCG YENYGKRCSM LSSVLAALIG IVGSAYCVIV ASLGLAEGPK
CSDAHGVWNY TFASTEGQYL LNSSMWSKCY EPKHIVEWHV TLFSILLAFA AVEFILCLIQ
VINGMLGGLC GYCCSRQQQY NC
