T4S1_PONAB
ID T4S1_PONAB Reviewed; 202 AA.
AC Q5RE43;
DT 21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 25-MAY-2022, entry version 50.
DE RecName: Full=Transmembrane 4 L6 family member 1;
GN Name=TM4SF1;
OS Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pongo.
OX NCBI_TaxID=9601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Heart;
RG The German cDNA consortium;
RL Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Present in high molecular weight complexes in tumor cells.
CC Interacts with SDCBP2 (By similarity). {ECO:0000250|UniProtKB:P30408}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC Note=Colocalizes with SDCBP2 in the apical region of the cell.
CC {ECO:0000250|UniProtKB:P30408}.
CC -!- SIMILARITY: Belongs to the L6 tetraspanin family. {ECO:0000305}.
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DR EMBL; CR857695; CAH89964.1; -; mRNA.
DR RefSeq; NP_001124924.1; NM_001131452.1.
DR AlphaFoldDB; Q5RE43; -.
DR STRING; 9601.ENSPPYP00000015877; -.
DR GeneID; 100171795; -.
DR KEGG; pon:100171795; -.
DR CTD; 4071; -.
DR eggNOG; ENOG502RY7H; Eukaryota.
DR InParanoid; Q5RE43; -.
DR OrthoDB; 922490at2759; -.
DR Proteomes; UP000001595; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR008661; L6_membrane.
DR PANTHER; PTHR14198; PTHR14198; 1.
DR Pfam; PF05805; L6_membrane; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..202
FT /note="Transmembrane 4 L6 family member 1"
FT /id="PRO_0000219298"
FT TOPO_DOM 1..9
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 10..30
FT /note="Helical"
FT /evidence="ECO:0000305"
FT TOPO_DOM 31..49
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 50..70
FT /note="Helical"
FT /evidence="ECO:0000305"
FT TOPO_DOM 71..93
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 94..114
FT /note="Helical"
FT /evidence="ECO:0000305"
FT TOPO_DOM 115..161
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 162..182
FT /note="Helical"
FT /evidence="ECO:0000305"
FT TOPO_DOM 183..202
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT CARBOHYD 129
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 159
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 202 AA; 21644 MW; 2B4E56AA8EEC1424 CRC64;
MCYGKCARCI GHSLVGLALL CIAANILLYF PNGETRYASE NHLSRFVWFF SGIVGGGLLM
LLPAFVLIGL EQDDCCGCCG HENCGKRCAM LSSVLAALIG IAGSGYCVIV AALGLAEGPL
CLDSLGQWNY TFASTEGQYL LDTSTWSQCT EPKHIVEWNV SLFSILLALG GIEFILCLIQ
VINGVLGGIC GFCCSRQQQY DC