T4S4_MOUSE
ID T4S4_MOUSE Reviewed; 202 AA.
AC Q91XD3;
DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 25-MAY-2022, entry version 90.
DE RecName: Full=Transmembrane 4 L6 family member 4;
GN Name=Tm4sf4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Regulates the adhesive and proliferative status of intestinal
CC epithelial cells. Can mediate density-dependent cell proliferation (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the L6 tetraspanin family. {ECO:0000305}.
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DR EMBL; BC010814; AAH10814.1; -; mRNA.
DR CCDS; CCDS17361.1; -.
DR AlphaFoldDB; Q91XD3; -.
DR STRING; 10090.ENSMUSP00000029377; -.
DR GlyGen; Q91XD3; 1 site.
DR PhosphoSitePlus; Q91XD3; -.
DR MaxQB; Q91XD3; -.
DR PaxDb; Q91XD3; -.
DR PRIDE; Q91XD3; -.
DR ProteomicsDB; 262995; -.
DR MGI; MGI:2385173; Tm4sf4.
DR eggNOG; ENOG502QVGK; Eukaryota.
DR InParanoid; Q91XD3; -.
DR PhylomeDB; Q91XD3; -.
DR PRO; PR:Q91XD3; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q91XD3; protein.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR InterPro; IPR008661; L6_membrane.
DR PANTHER; PTHR14198; PTHR14198; 1.
DR Pfam; PF05805; L6_membrane; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..202
FT /note="Transmembrane 4 L6 family member 4"
FT /id="PRO_0000219300"
FT TOPO_DOM 1..9
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 10..30
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 31..48
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 49..69
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 70..93
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..114
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 115..158
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 159..179
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 180..202
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 156
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 202 AA; 21296 MW; 764077FC21410635 CRC64;
MCTGGCARCL GGTLIPLAVF GLLANILLFF PGGKVVNDKS HLSDEVWYFG GILGSGVLMI
FPALVFLGLQ NNDCCGCCGN EGCGKRFAMF TSTLFAVIGF LGAGYSFIVS AVSINKGPKC
FMANGTWGYP FHDGDYLKDQ ALWSECEEPR DVVPWNLTLF SILLVIGGIQ MVLCAIQVIN
GLLGTLCGDC QCCGCCGGDG PV
