ID   T4S4_RAT                Reviewed;         202 AA.
AC   Q9EQL5;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Transmembrane 4 L6 family member 4;
GN   Name=Tm4sf4; Synonyms=Lrtm4;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   STRAIN=Sprague-Dawley;
RX   PubMed=11267677; DOI=10.1016/s0167-4781(01)00170-1;
RA   Liu Z.W., Zhao M.J., Yokoyama K.K., Li T.P.;
RT   "Molecular cloning of a cDNA for rat TM4SF4, a homolog of human il-TMP
RT   (TM4SF4), and enhanced expression of the corresponding gene in regenerating
RT   rat liver.";
RL   Biochim. Biophys. Acta 1518:183-189(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Regulates the adhesive and proliferative status of intestinal
CC       epithelial cells. Can mediate density-dependent cell proliferation (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in liver and testis. Up-regulated in
CC       regenerating liver after partial hepatectomy.
CC       {ECO:0000269|PubMed:11267677}.
CC   -!- SIMILARITY: Belongs to the L6 tetraspanin family. {ECO:0000305}.
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DR   EMBL; AF205717; AAG35665.1; -; mRNA.
DR   EMBL; BC091131; AAH91131.1; -; mRNA.
DR   RefSeq; NP_446237.1; NM_053785.1.
DR   AlphaFoldDB; Q9EQL5; -.
DR   STRING; 10116.ENSRNOP00000022105; -.
DR   GlyGen; Q9EQL5; 1 site.
DR   PaxDb; Q9EQL5; -.
DR   Ensembl; ENSRNOT00000022105; ENSRNOP00000022105; ENSRNOG00000016437.
DR   GeneID; 116467; -.
DR   KEGG; rno:116467; -.
DR   UCSC; RGD:621784; rat.
DR   CTD; 7104; -.
DR   RGD; 621784; Tm4sf4.
DR   eggNOG; ENOG502QVGK; Eukaryota.
DR   GeneTree; ENSGT01030000234590; -.
DR   HOGENOM; CLU_087168_1_0_1; -.
DR   InParanoid; Q9EQL5; -.
DR   OMA; CGCCGNQ; -.
DR   OrthoDB; 922490at2759; -.
DR   PhylomeDB; Q9EQL5; -.
DR   TreeFam; TF331371; -.
DR   PRO; PR:Q9EQL5; -.
DR   Proteomes; UP000002494; Chromosome 2.
DR   Bgee; ENSRNOG00000016437; Expressed in duodenum and 16 other tissues.
DR   Genevisible; Q9EQL5; RN.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0042246; P:tissue regeneration; IEP:RGD.
DR   InterPro; IPR008661; L6_membrane.
DR   PANTHER; PTHR14198; PTHR14198; 1.
DR   Pfam; PF05805; L6_membrane; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..202
FT                   /note="Transmembrane 4 L6 family member 4"
FT                   /id="PRO_0000219302"
FT   TOPO_DOM        1..9
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        10..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        31..48
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        49..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        70..93
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        94..114
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        115..158
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        159..179
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        180..202
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        156
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   202 AA;  21484 MW;  8E97E5F699A2CE2B CRC64;
     MCTGGCARCL GGTLIPLAVF AVLANILLFF PGGKVVDDNS HLSDEVWYFG GILGSGVLMI
     FPALVFLGLQ NNDCCGCCGN ESCGKRFAMF TSTLFAVVGF LGAAYSFIVS AVSINKGPKC
     FMTNNTWGYP FHDGDYLNDQ ALWSKCEEPR DVVPWNLTLF SILLVIGGIQ MVLCAIQVIN
     GLLGTLCGDC QCCGCCGGDR PV