ID   ABT1_RAT                Reviewed;         268 AA.
AC   Q4KLM5;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=Activator of basal transcription 1;
GN   Name=Abt1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   INTERACTION WITH ESF1.
RX   PubMed=10648625; DOI=10.1128/mcb.20.4.1407-1418.2000;
RA   Oda T., Kayukawa K., Hagiwara H., Yudate H.T., Masuho Y., Murakami Y.,
RA   Tamura T.-A., Muramatsu M.-A.;
RT   "A novel TATA-binding protein-binding protein, ABT1, activates basal
RT   transcription and has a yeast homolog that is essential for growth.";
RL   Mol. Cell. Biol. 20:1407-1418(2000).
CC   -!- FUNCTION: May be a novel TATA-binding protein (TBP) which can function
CC       as a basal transcription activator. Can act as a regulator of basal
CC       transcription for class II genes (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with IGHMBP2 (By similarity). Interacts with
CC       ESF1/ABTAP. {ECO:0000250, ECO:0000269|PubMed:10648625}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Nucleus, nucleolus
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ESF2/ABP1 family. {ECO:0000305}.
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DR   EMBL; BC099109; AAH99109.1; -; mRNA.
DR   RefSeq; NP_001020845.1; NM_001025674.1.
DR   AlphaFoldDB; Q4KLM5; -.
DR   STRING; 10116.ENSRNOP00000023648; -.
DR   PaxDb; Q4KLM5; -.
DR   Ensembl; ENSRNOT00000023649; ENSRNOP00000023648; ENSRNOG00000017585.
DR   GeneID; 306960; -.
DR   KEGG; rno:306960; -.
DR   UCSC; RGD:1310785; rat.
DR   CTD; 29777; -.
DR   RGD; 1310785; Abt1.
DR   eggNOG; KOG3152; Eukaryota.
DR   GeneTree; ENSGT00390000002062; -.
DR   HOGENOM; CLU_054086_3_1_1; -.
DR   InParanoid; Q4KLM5; -.
DR   OMA; TRPNSSW; -.
DR   OrthoDB; 1377351at2759; -.
DR   PhylomeDB; Q4KLM5; -.
DR   TreeFam; TF314506; -.
DR   PRO; PR:Q4KLM5; -.
DR   Proteomes; UP000002494; Chromosome 17.
DR   Bgee; ENSRNOG00000017585; Expressed in thymus and 20 other tissues.
DR   Genevisible; Q4KLM5; RN.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0005667; C:transcription regulator complex; ISO:RGD.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0000480; P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   GO; GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   GO; GO:0000472; P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISO:RGD.
DR   GO; GO:0034462; P:small-subunit processome assembly; IBA:GO_Central.
DR   GO; GO:0021522; P:spinal cord motor neuron differentiation; ISO:RGD.
DR   CDD; cd12263; RRM_ABT1_like; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR039119; ABT1/Esf2.
DR   InterPro; IPR034353; ABT1/ESF2_RRM.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   PANTHER; PTHR12311; PTHR12311; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; DNA-binding; Nucleus; Reference proteome; RNA-binding;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..268
FT                   /note="Activator of basal transcription 1"
FT                   /id="PRO_0000233171"
FT   DOMAIN          47..144
FT                   /note="RRM"
FT   REGION          200..242
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          6..38
FT                   /evidence="ECO:0000255"
FT   COILED          163..193
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        205..221
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   268 AA;  30620 MW;  98E9A2CED07AAD7E CRC64;
     MVKVGKLVEE QKAAMEEEKE VNAEAAEELE EAEEASCNGS KKKVVPGIVY LGHVPPRFRP
     LHVRNLLSVY GEVGRVFFQA EDPFVRRKKK AAAAAGGKKG AKYSKDYTEG WVEFRDKRIA
     KRVAASLHNT PMGARKRSPF RYDLWNLKYL HRFTWSHLSE HLAFERQVRR QRLRAEVAQA
     KRETDFYLRN VEQGQRFLAA DGDATRPNSS WTFTQRPTEQ ELRAQKGARP GGRERARLAT
     VQDQARSNRG LLARIFGASL LAESRKEP