T53G3_HUMAN
ID T53G3_HUMAN Reviewed; 124 AA.
AC Q9ULZ0; B2R5K6; Q4KN31; Q9ULY9;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 03-JUL-2019, sequence version 2.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=TP53-target gene 3 protein {ECO:0000305};
DE AltName: Full=TP53-inducible gene 3 protein;
GN Name=TP53TG3 {ECO:0000312|HGNC:HGNC:30759}; Synonyms=TP53TG3A;
GN and
GN Name=TP53TG3B {ECO:0000312|HGNC:HGNC:37202};
GN and
GN Name=TP53TG3C {ECO:0000312|HGNC:HGNC:42962};
GN and
GN Name=TP53TG3D {ECO:0000312|HGNC:HGNC:44657};
GN and
GN Name=TP53TG3E {ECO:0000312|HGNC:HGNC:51816};
GN and
GN Name=TP53TG3F {ECO:0000312|HGNC:HGNC:51817};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, INDUCTION BY TP53,
RP TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RX PubMed=10534768;
RX DOI=10.1002/(sici)1098-2264(199912)26:4<329::aid-gcc7>3.0.co;2-c;
RA Ng C.C., Koyama K., Okamura S., Kondoh H., Takei Y., Nakamura Y.;
RT "Isolation and characterization of a novel TP53-inducible gene, TP53TG3.";
RL Genes Chromosomes Cancer 26:329-335(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May play a significant role in p53/TP53-mediating signaling
CC pathway. {ECO:0000269|PubMed:10534768}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10534768}. Nucleus
CC {ECO:0000269|PubMed:10534768}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=2; Synonyms=TP53TG3a;
CC IsoId=Q9ULZ0-2; Sequence=Displayed;
CC Name=1; Synonyms=TP53TG3b;
CC IsoId=Q9ULZ0-1; Sequence=VSP_060199;
CC Name=3;
CC IsoId=Q9ULZ0-3; Sequence=VSP_060197, VSP_060198;
CC -!- TISSUE SPECIFICITY: Strongly expressed in testis. Weakly expressed in
CC heart, placenta and skeletal muscle. {ECO:0000269|PubMed:10534768}.
CC -!- INDUCTION: By p53/TP53. {ECO:0000269|PubMed:10534768}.
CC -!- MISCELLANEOUS: [Isoform 1]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
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DR EMBL; AB023508; BAA84978.1; -; mRNA.
DR EMBL; AB023509; BAA84979.1; -; mRNA.
DR EMBL; CR541650; CAG46451.1; -; mRNA.
DR EMBL; AK312220; BAG35153.1; -; mRNA.
DR EMBL; AL133588; CAH10710.1; -; mRNA.
DR EMBL; BC096700; AAH96700.1; -; mRNA.
DR EMBL; BC096733; AAH96733.1; -; mRNA.
DR EMBL; BC098165; AAH98165.1; -; mRNA.
DR EMBL; BC099842; AAH99842.1; -; mRNA.
DR CCDS; CCDS45475.1; -. [Q9ULZ0-2]
DR CCDS; CCDS45477.1; -. [Q9ULZ0-2]
DR CCDS; CCDS58456.1; -. [Q9ULZ0-2]
DR CCDS; CCDS58458.1; -. [Q9ULZ0-2]
DR CCDS; CCDS81974.1; -. [Q9ULZ0-2]
DR CCDS; CCDS81976.1; -. [Q9ULZ0-2]
DR RefSeq; NP_001093157.1; NM_001099687.3. [Q9ULZ0-2]
DR RefSeq; NP_001192188.1; NM_001205259.2. [Q9ULZ0-2]
DR RefSeq; NP_001230651.1; NM_001243722.2. [Q9ULZ0-2]
DR RefSeq; NP_001316990.1; NM_001330061.1. [Q9ULZ0-2]
DR RefSeq; NP_001316995.1; NM_001330066.1. [Q9ULZ0-2]
DR RefSeq; NP_057296.1; NM_016212.4. [Q9ULZ0-2]
DR RefSeq; XP_006721089.1; XM_006721026.1. [Q9ULZ0-1]
DR RefSeq; XP_006721137.1; XM_006721074.2. [Q9ULZ0-1]
DR RefSeq; XP_006721147.1; XM_006721084.1. [Q9ULZ0-1]
DR RefSeq; XP_006721180.1; XM_006721117.2. [Q9ULZ0-1]
DR RefSeq; XP_006721181.1; XM_006721118.1. [Q9ULZ0-1]
DR RefSeq; XP_006724967.1; XM_006724904.3. [Q9ULZ0-1]
DR RefSeq; XP_006724968.1; XM_006724905.3.
DR RefSeq; XP_011544081.1; XM_011545779.1. [Q9ULZ0-1]
DR RefSeq; XP_011544222.1; XM_011545920.1. [Q9ULZ0-1]
DR RefSeq; XP_011544235.1; XM_011545933.1. [Q9ULZ0-1]
DR RefSeq; XP_011544334.1; XM_011546032.1. [Q9ULZ0-1]
DR RefSeq; XP_011544335.1; XM_011546033.1. [Q9ULZ0-1]
DR RefSeq; XP_011544539.1; XM_011546237.1. [Q9ULZ0-1]
DR RefSeq; XP_011544540.1; XM_011546238.1. [Q9ULZ0-1]
DR RefSeq; XP_016878592.1; XM_017023103.1. [Q9ULZ0-1]
DR RefSeq; XP_016879081.1; XM_017023592.1.
DR RefSeq; XP_016879082.1; XM_017023593.1.
DR RefSeq; XP_016879124.1; XM_017023635.1.
DR RefSeq; XP_016879125.1; XM_017023636.1.
DR RefSeq; XP_016879126.1; XM_017023637.1. [Q9ULZ0-1]
DR RefSeq; XP_016879128.1; XM_017023639.1. [Q9ULZ0-1]
DR RefSeq; XP_016879441.1; XM_017023952.1.
DR RefSeq; XP_016879442.1; XM_017023953.1.
DR RefSeq; XP_016879446.1; XM_017023957.1.
DR RefSeq; XP_016879447.1; XM_017023958.1.
DR RefSeq; XP_016885615.1; XM_017030126.1. [Q9ULZ0-1]
DR RefSeq; XP_016885616.1; XM_017030127.1. [Q9ULZ0-1]
DR AlphaFoldDB; Q9ULZ0; -.
DR BioGRID; 117300; 1.
DR IntAct; Q9ULZ0; 1.
DR STRING; 9606.ENSP00000339405; -.
DR iPTMnet; Q9ULZ0; -.
DR PhosphoSitePlus; Q9ULZ0; -.
DR BioMuta; TP53TG3; -.
DR PaxDb; Q9ULZ0; -.
DR PRIDE; Q9ULZ0; -.
DR ProteomicsDB; 85155; -. [Q9ULZ0-3]
DR Antibodypedia; 54688; 13 antibodies from 2 providers.
DR Antibodypedia; 60073; 14 antibodies from 3 providers.
DR DNASU; 24150; -.
DR Ensembl; ENST00000341305.6; ENSP00000339405.5; ENSG00000261509.6. [Q9ULZ0-2]
DR Ensembl; ENST00000360260.6; ENSP00000353397.2; ENSG00000205457.11. [Q9ULZ0-3]
DR Ensembl; ENST00000380148.6; ENSP00000454398.1; ENSG00000205456.11. [Q9ULZ0-1]
DR Ensembl; ENST00000398664.4; ENSP00000455596.1; ENSG00000205456.11. [Q9ULZ0-2]
DR Ensembl; ENST00000398682.4; ENSP00000381672.4; ENSG00000183632.14. [Q9ULZ0-2]
DR Ensembl; ENST00000561509.2; ENSP00000455132.1; ENSG00000205457.11. [Q9ULZ0-2]
DR Ensembl; ENST00000565622.5; ENSP00000455448.1; ENSG00000183632.14. [Q9ULZ0-1]
DR Ensembl; ENST00000567137.1; ENSP00000454442.1; ENSG00000205457.11. [Q9ULZ0-3]
DR Ensembl; ENST00000567724.5; ENSP00000457303.1; ENSG00000261509.6. [Q9ULZ0-1]
DR Ensembl; ENST00000569420.1; ENSP00000457452.1; ENSG00000183632.14. [Q9ULZ0-3]
DR Ensembl; ENST00000569719.5; ENSP00000457790.1; ENSG00000205457.11. [Q9ULZ0-1]
DR Ensembl; ENST00000569741.1; ENSP00000456831.1; ENSG00000261509.6. [Q9ULZ0-3]
DR Ensembl; ENST00000611321.1; ENSP00000482283.1; ENSG00000275034.2. [Q9ULZ0-3]
DR Ensembl; ENST00000617705.1; ENSP00000481405.1; ENSG00000278848.2. [Q9ULZ0-3]
DR Ensembl; ENST00000623042.1; ENSP00000485635.1; ENSG00000278848.2. [Q9ULZ0-2]
DR Ensembl; ENST00000623491.1; ENSP00000485467.1; ENSG00000275034.2. [Q9ULZ0-2]
DR GeneID; 102723655; -.
DR GeneID; 102723713; -.
DR GeneID; 102724101; -.
DR GeneID; 102724127; -.
DR GeneID; 24150; -.
DR GeneID; 653550; -.
DR GeneID; 729264; -.
DR GeneID; 729355; -.
DR KEGG; hsa:102724101; -.
DR KEGG; hsa:102724127; -.
DR KEGG; hsa:24150; -.
DR KEGG; hsa:653550; -.
DR KEGG; hsa:729264; -.
DR KEGG; hsa:729355; -.
DR MANE-Select; ENST00000341305.7; ENSP00000339405.5; NM_001099687.4; NP_001093157.1.
DR MANE-Select; ENST00000398664.5; ENSP00000455596.1; NM_001243722.3; NP_001230651.1.
DR MANE-Select; ENST00000398682.5; ENSP00000381672.4; NM_016212.5; NP_057296.1.
DR MANE-Select; ENST00000561509.3; ENSP00000455132.1; NM_001205259.3; NP_001192188.1.
DR MANE-Select; ENST00000623042.2; ENSP00000485635.1; NM_001330066.2; NP_001316995.1.
DR MANE-Select; ENST00000623491.2; ENSP00000485467.1; NM_001330061.2; NP_001316990.1.
DR UCSC; uc002edd.5; human. [Q9ULZ0-2]
DR CTD; 102724101; -.
DR CTD; 102724127; -.
DR CTD; 24150; -.
DR CTD; 653550; -.
DR CTD; 729264; -.
DR CTD; 729355; -.
DR DisGeNET; 24150; -.
DR GeneCards; TP53TG3; -.
DR GeneCards; TP53TG3B; -.
DR GeneCards; TP53TG3C; -.
DR GeneCards; TP53TG3D; -.
DR GeneCards; TP53TG3E; -.
DR GeneCards; TP53TG3F; -.
DR HGNC; HGNC:30759; TP53TG3.
DR HGNC; HGNC:37202; TP53TG3B.
DR HGNC; HGNC:42962; TP53TG3C.
DR HGNC; HGNC:44657; TP53TG3D.
DR HGNC; HGNC:51816; TP53TG3E.
DR HGNC; HGNC:51817; TP53TG3F.
DR HPA; ENSG00000183632; Not detected.
DR HPA; ENSG00000205456; Tissue enhanced (epididymis, testis).
DR HPA; ENSG00000205457; Not detected.
DR HPA; ENSG00000261509; Tissue enriched (epididymis).
DR HPA; ENSG00000275034; Not detected.
DR HPA; ENSG00000278848; Group enriched (epididymis, testis).
DR MIM; 617482; gene.
DR neXtProt; NX_Q9ULZ0; -.
DR OpenTargets; ENSG00000183632; -.
DR OpenTargets; ENSG00000205456; -.
DR OpenTargets; ENSG00000205457; -.
DR PharmGKB; PA165450804; -.
DR VEuPathDB; HostDB:ENSG00000183632; -.
DR VEuPathDB; HostDB:ENSG00000205456; -.
DR VEuPathDB; HostDB:ENSG00000205457; -.
DR VEuPathDB; HostDB:ENSG00000261509; -.
DR VEuPathDB; HostDB:ENSG00000275034; -.
DR VEuPathDB; HostDB:ENSG00000278848; -.
DR eggNOG; ENOG502TEEP; Eukaryota.
DR GeneTree; ENSGT00390000001729; -.
DR HOGENOM; CLU_1916346_0_0_1; -.
DR InParanoid; Q9ULZ0; -.
DR OMA; WHPRHSA; -.
DR OrthoDB; 1421857at2759; -.
DR PhylomeDB; Q9ULZ0; -.
DR TreeFam; TF342471; -.
DR PathwayCommons; Q9ULZ0; -.
DR SignaLink; Q9ULZ0; -.
DR BioGRID-ORCS; 102723655; 0 hits in 3 CRISPR screens.
DR BioGRID-ORCS; 102723713; 0 hits in 3 CRISPR screens.
DR BioGRID-ORCS; 102724101; 0 hits in 3 CRISPR screens.
DR BioGRID-ORCS; 102724127; 0 hits in 10 CRISPR screens.
DR BioGRID-ORCS; 24150; 25 hits in 242 CRISPR screens.
DR BioGRID-ORCS; 653550; 21 hits in 517 CRISPR screens.
DR BioGRID-ORCS; 729264; 17 hits in 268 CRISPR screens.
DR BioGRID-ORCS; 729355; 25 hits in 207 CRISPR screens.
DR Pharos; Q9ULZ0; Tdark.
DR PRO; PR:Q9ULZ0; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; Q9ULZ0; protein.
DR Bgee; ENSG00000183632; Expressed in left testis and 76 other tissues.
DR ExpressionAtlas; Q9ULZ0; baseline and differential.
DR Genevisible; Q9ULZ0; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytoplasm; Nucleus; Reference proteome.
FT CHAIN 1..124
FT /note="TP53-target gene 3 protein"
FT /id="PRO_0000328983"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 81..102
FT /note="NCDTLSPRAAGFYACHVRSLIP -> CHKSSAPQERRLDPRARCVVHI (in
FT isoform 3)"
FT /id="VSP_060197"
FT VAR_SEQ 103..124
FT /note="Missing (in isoform 3)"
FT /id="VSP_060198"
FT VAR_SEQ 121..124
FT /note="SFSG -> RHAQCGPSLGLG (in isoform 1)"
FT /id="VSP_060199"
SQ SEQUENCE 124 AA; 12828 MW; FD05DF7A8D1E79AE CRC64;
MRASPCISQP AASWHPRPSA LRPTAGSGPD TRTPGTVEDG SAPCPAFRSP AVSPCGEEPC
CFQISPAEET LELGRLVSPG NCDTLSPRAA GFYACHVRSL IPCRSTKGRW PLTASAAGLS
SFSG
