T53G5_HUMAN
ID T53G5_HUMAN Reviewed; 290 AA.
AC Q9Y2B4;
DT 10-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=TP53-target gene 5 protein;
DE AltName: Full=TP53-inducible gene 5 protein;
GN Name=TP53TG5; Synonyms=C20orf10;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH TP53, SUBCELLULAR
RP LOCATION, TISSUE SPECIFICITY, AND INDUCTION.
RC TISSUE=Testis;
RX PubMed=10719363;
RX DOI=10.1002/(sici)1098-2264(200004)27:4<345::aid-gcc2>3.0.co;2-3;
RA Isaka S., Takei Y., Tokino T., Koyama K., Miyoshi Y., Suzuki M.,
RA Takahashi E., Azuma C., Murata Y., Nakamura Y.;
RT "Isolation and characterization of a novel TP53-inducible gene, TP53TG5,
RT which suppresses growth and shows cell cycle-dependent transition of
RT expression.";
RL Genes Chromosomes Cancer 27:345-352(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May play a significant role in p53/TP53-mediating signaling
CC pathway. {ECO:0000269|PubMed:10719363}.
CC -!- SUBUNIT: Interacts with p53/TP53. {ECO:0000269|PubMed:10719363}.
CC -!- INTERACTION:
CC Q9Y2B4; P28799-2: GRN; NbExp=3; IntAct=EBI-21870909, EBI-25860013;
CC Q9Y2B4; I6L9F6: NEFL; NbExp=3; IntAct=EBI-21870909, EBI-10178578;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10719363}. Nucleus
CC {ECO:0000269|PubMed:10719363}. Note=Cell cycle dependent intracellular
CC localization.
CC -!- TISSUE SPECIFICITY: Highly expressed in heart, brain and small
CC intestine. Less abundant in skeletal muscle, spleen, prostate, ovary
CC and colon. A smaller transcript is expressed specifically in the
CC testis. {ECO:0000269|PubMed:10719363}.
CC -!- INDUCTION: By p53/TP53, UV irradiation, by hydrogen peroxide treatment
CC or by treatment with a DNA-damaging reagent.
CC {ECO:0000269|PubMed:10719363}.
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DR EMBL; AB017802; BAA76405.1; -; mRNA.
DR EMBL; AL021578; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC036785; AAH36785.1; -; mRNA.
DR CCDS; CCDS13352.1; -.
DR RefSeq; NP_055292.1; NM_014477.2.
DR AlphaFoldDB; Q9Y2B4; -.
DR SMR; Q9Y2B4; -.
DR BioGRID; 118120; 8.
DR IntAct; Q9Y2B4; 6.
DR STRING; 9606.ENSP00000361811; -.
DR iPTMnet; Q9Y2B4; -.
DR PhosphoSitePlus; Q9Y2B4; -.
DR BioMuta; TP53TG5; -.
DR DMDM; 23822283; -.
DR MassIVE; Q9Y2B4; -.
DR PaxDb; Q9Y2B4; -.
DR PeptideAtlas; Q9Y2B4; -.
DR PRIDE; Q9Y2B4; -.
DR ProteomicsDB; 85719; -.
DR Antibodypedia; 27611; 224 antibodies from 19 providers.
DR DNASU; 27296; -.
DR Ensembl; ENST00000372726.5; ENSP00000361811.3; ENSG00000124251.11.
DR GeneID; 27296; -.
DR KEGG; hsa:27296; -.
DR MANE-Select; ENST00000372726.5; ENSP00000361811.3; NM_014477.3; NP_055292.1.
DR UCSC; uc002xny.4; human.
DR CTD; 27296; -.
DR GeneCards; TP53TG5; -.
DR HGNC; HGNC:15856; TP53TG5.
DR HPA; ENSG00000124251; Tissue enriched (testis).
DR MIM; 617316; gene.
DR neXtProt; NX_Q9Y2B4; -.
DR OpenTargets; ENSG00000124251; -.
DR PharmGKB; PA25639; -.
DR VEuPathDB; HostDB:ENSG00000124251; -.
DR eggNOG; ENOG502SYWX; Eukaryota.
DR GeneTree; ENSGT00390000017387; -.
DR HOGENOM; CLU_083634_0_0_1; -.
DR InParanoid; Q9Y2B4; -.
DR OMA; MQDEKPQ; -.
DR OrthoDB; 1410139at2759; -.
DR PhylomeDB; Q9Y2B4; -.
DR TreeFam; TF337759; -.
DR PathwayCommons; Q9Y2B4; -.
DR SignaLink; Q9Y2B4; -.
DR BioGRID-ORCS; 27296; 15 hits in 1067 CRISPR screens.
DR GenomeRNAi; 27296; -.
DR Pharos; Q9Y2B4; Tdark.
DR PRO; PR:Q9Y2B4; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q9Y2B4; protein.
DR Bgee; ENSG00000124251; Expressed in C1 segment of cervical spinal cord and 123 other tissues.
DR Genevisible; Q9Y2B4; HS.
DR GO; GO:0005694; C:chromosome; IDA:HPA.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; IDA:HPA.
DR GO; GO:0005634; C:nucleus; HDA:UniProtKB.
DR GO; GO:0035556; P:intracellular signal transduction; NAS:UniProtKB.
DR GO; GO:0030308; P:negative regulation of cell growth; NAS:UniProtKB.
DR InterPro; IPR029290; TP53TG5.
DR PANTHER; PTHR15562; PTHR15562; 1.
DR Pfam; PF15331; TP53IP5; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Nucleus; Reference proteome.
FT CHAIN 1..290
FT /note="TP53-target gene 5 protein"
FT /id="PRO_0000072405"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 114..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..29
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 114..135
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 144..163
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 57
FT /note="R -> H (in dbSNP:rs2231616)"
FT /id="VAR_051397"
FT VARIANT 172
FT /note="V -> A (in dbSNP:rs2231619)"
FT /id="VAR_051398"
FT VARIANT 191
FT /note="R -> H (in dbSNP:rs2231620)"
FT /id="VAR_051399"
FT VARIANT 219
FT /note="H -> Q (in dbSNP:rs2231622)"
FT /id="VAR_051400"
FT VARIANT 221
FT /note="P -> L (in dbSNP:rs2231623)"
FT /id="VAR_051401"
FT VARIANT 257
FT /note="V -> A (in dbSNP:rs2231627)"
FT /id="VAR_051402"
FT VARIANT 275
FT /note="H -> N (in dbSNP:rs2231628)"
FT /id="VAR_051403"
SQ SEQUENCE 290 AA; 34019 MW; D3206C95021473E3 CRC64;
MSPSAKKRPK NSRVSKMQDE KLRDETEQPV SKVIERNRLR TVLKNLSLLK LLKSSNRRIQ
ELHKLAKRCW HSLLSVPKIL RISSGENSAC NKTKQNNEEF QEIGCSEKEL KSKKLESTGD
PKKKEYKEWK SQVQSGMRNK EKTSLAAMPR KEKHIEPEVP RTSRDDSLNP GVQGRQPLTE
GPRVIFIKPY RNRTPMGHMK QLDVADQWIW FEGLPTRIHL PAPRVMCRSS TLRWVKRRCT
RFCSASLEMP MWHPYKVDVT WTRARGASRG WRSRHQLKGR NGWRNSRVYK
