ID   T55BA_DANRE             Reviewed;         270 AA.
AC   Q32PR0;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Type I phosphatidylinositol 4,5-bisphosphate 4-phosphatase-A;
DE            Short=PtdIns-4,5-P2 4-Ptase I-A;
DE            EC=3.1.3.78;
DE   AltName: Full=Transmembrane protein 55B-A;
GN   Name=tmem55ba; ORFNames=zgc:123304;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the hydrolysis of the 4-position phosphate of
CC       phosphatidylinositol 4,5-bisphosphate. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-
CC         bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
CC         inositol-5-phosphate) + phosphate; Xref=Rhea:RHEA:25674,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57795,
CC         ChEBI:CHEBI:58456; EC=3.1.3.78;
CC   -!- SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}. Lysosome membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000250}.
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DR   EMBL; BC108019; AAI08020.1; -; mRNA.
DR   RefSeq; NP_001032453.1; NM_001037376.1.
DR   AlphaFoldDB; Q32PR0; -.
DR   STRING; 7955.ENSDARP00000115253; -.
DR   PaxDb; Q32PR0; -.
DR   Ensembl; ENSDART00000146192; ENSDARP00000115253; ENSDARG00000038615.
DR   Ensembl; ENSDART00000181847; ENSDARP00000146886; ENSDARG00000112736.
DR   Ensembl; ENSDART00000188560; ENSDARP00000148108; ENSDARG00000112297.
DR   GeneID; 556136; -.
DR   KEGG; dre:556136; -.
DR   CTD; 556136; -.
DR   ZFIN; ZDB-GENE-051113-312; pip4p1a.
DR   eggNOG; KOG4684; Eukaryota.
DR   GeneTree; ENSGT00390000003680; -.
DR   HOGENOM; CLU_087485_0_0_1; -.
DR   InParanoid; Q32PR0; -.
DR   OMA; APYGVPN; -.
DR   OrthoDB; 1346704at2759; -.
DR   PhylomeDB; Q32PR0; -.
DR   TreeFam; TF316367; -.
DR   Reactome; R-DRE-6811555; PI5P Regulates TP53 Acetylation.
DR   Reactome; R-DRE-8847453; Synthesis of PIPs in the nucleus.
DR   PRO; PR:Q32PR0; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 2.
DR   Bgee; ENSDARG00000038615; Expressed in brain and 28 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031902; C:late endosome membrane; IBA:GO_Central.
DR   GO; GO:0005765; C:lysosomal membrane; IBA:GO_Central.
DR   GO; GO:0030670; C:phagocytic vesicle membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0034597; F:phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity; IBA:GO_Central.
DR   GO; GO:0046856; P:phosphatidylinositol dephosphorylation; IBA:GO_Central.
DR   InterPro; IPR019178; PtdIns-P2-Ptase.
DR   PANTHER; PTHR21014; PTHR21014; 1.
DR   Pfam; PF09788; Tmemb_55A; 1.
PE   2: Evidence at transcript level;
KW   Endosome; Hydrolase; Lysosome; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..270
FT                   /note="Type I phosphatidylinositol 4,5-bisphosphate 4-
FT                   phosphatase-A"
FT                   /id="PRO_0000235236"
FT   TRANSMEM        206..226
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        232..252
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..71
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           126..132
FT                   /note="CX5R motif"
FT   COMPBIAS        38..66
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        126
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   270 AA;  28766 MW;  1FC0E4BCB7BC20BB CRC64;
     MADGERSPLL SDLGDGALGS GNGGVSPGAA SLGAPNKPQS FPPFPSSTQP PVLLSENPPP
     YSPLTSPESG SAPVISCRVC QSLISVEGKI HQHVVKCGVC NEATPIKNAP AGKKYVRCPC
     NCLLICKVTS QRIACPRPYC KRIINLGPVH PGPASPDPQP AGARVSCGHC SNTFLWTEFT
     DRTLARCPHC RKVSSIGQRY PRRRSLWCYL LCLLFSISAA GLIAGTWSQA QVYGGIYASW
     AAALLLVVLT LARALYWSCM RVSQPLHNLT