ID   T55BB_DANRE             Reviewed;         262 AA.
AC   Q66I51;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 2.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Type I phosphatidylinositol 4,5-bisphosphate 4-phosphatase-B;
DE            Short=PtdIns-4,5-P2 4-Ptase I-B;
DE            EC=3.1.3.78;
DE   AltName: Full=Transmembrane protein 55B-B;
GN   Name=tmem55bb;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the hydrolysis of the 4-position phosphate of
CC       phosphatidylinositol 4,5-bisphosphate. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-
CC         bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
CC         inositol-5-phosphate) + phosphate; Xref=Rhea:RHEA:25674,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:57795,
CC         ChEBI:CHEBI:58456; EC=3.1.3.78;
CC   -!- SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}. Lysosome membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH81529.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC081529; AAH81529.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001153393.1; NM_001159921.1.
DR   AlphaFoldDB; Q66I51; -.
DR   SMR; Q66I51; -.
DR   STRING; 7955.ENSDARP00000029568; -.
DR   PaxDb; Q66I51; -.
DR   PRIDE; Q66I51; -.
DR   Ensembl; ENSDART00000029774; ENSDARP00000029568; ENSDARG00000026387.
DR   GeneID; 553253; -.
DR   KEGG; dre:553253; -.
DR   CTD; 553253; -.
DR   ZFIN; ZDB-GENE-121214-195; pip4p1b.
DR   eggNOG; KOG4684; Eukaryota.
DR   GeneTree; ENSGT00390000003680; -.
DR   HOGENOM; CLU_087485_0_0_1; -.
DR   InParanoid; Q66I51; -.
DR   OMA; GIYVSWV; -.
DR   OrthoDB; 1346704at2759; -.
DR   PhylomeDB; Q66I51; -.
DR   TreeFam; TF316367; -.
DR   PRO; PR:Q66I51; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 1.
DR   Bgee; ENSDARG00000026387; Expressed in mature ovarian follicle and 19 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031902; C:late endosome membrane; IBA:GO_Central.
DR   GO; GO:0005765; C:lysosomal membrane; IBA:GO_Central.
DR   GO; GO:0030670; C:phagocytic vesicle membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0034597; F:phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity; IBA:GO_Central.
DR   GO; GO:0046856; P:phosphatidylinositol dephosphorylation; IBA:GO_Central.
DR   InterPro; IPR019178; PtdIns-P2-Ptase.
DR   PANTHER; PTHR21014; PTHR21014; 1.
DR   Pfam; PF09788; Tmemb_55A; 1.
PE   2: Evidence at transcript level;
KW   Endosome; Hydrolase; Lysosome; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..262
FT                   /note="Type I phosphatidylinositol 4,5-bisphosphate 4-
FT                   phosphatase-B"
FT                   /id="PRO_0000235237"
FT   TRANSMEM        198..218
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        227..247
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           118..124
FT                   /note="CX5R motif"
FT   ACT_SITE        118
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   262 AA;  28598 MW;  C5787AAE192AF684 CRC64;
     MADGERSPLL LDGRDGMTGL SLGDEPYRPI SKPQNFAVFP SAPPMLGEAP PPYSPLGSPE
     SSSAPVISCR VCQSLISVEG KIHQHVVKCG VCNEATPIKN APAGKKYVRC PCNCLLICKV
     TSQRIACPRP YCKRVINLGP VNPGAGSPNP QPTGARVSCG HCAKTFLWTE FTDRTLARCP
     HCRKVSSIGQ RYPRKRSLIC FLLCLIFVIT TAGLIAGTWL KAQKYKGIYA SWVFFIVLVL
     VTLVRALHWA CMKISEPLHN YS