ID   T61_TERGU               Reviewed;          96 AA.
AC   A0A141TBR6;
DT   23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT   23-FEB-2022, sequence version 2.
DT   03-AUG-2022, entry version 6.
DE   RecName: Full=Teretoxin Tgu6.1 {ECO:0000303|PubMed:26950153};
DE   AltName: Full=Teretoxin peptide 6.1 {ECO:0000312|EMBL:AML61541.1};
DE   Flags: Precursor;
OS   Terebra guttata (White spotted auger snail) (Epitonium guttatum).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Terebridae; Terebra.
OX   NCBI_TaxID=553711;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, BIOASSAY, AND RECOMBINANT EXPRESSION.
RX   PubMed=26950153; DOI=10.3390/toxins8030063;
RA   Moon J., Gorson J., Wright M.E., Yee L., Khawaja S., Shin H.Y., Karma Y.,
RA   Musunri R.L., Yun M., Holford M.;
RT   "Characterization and recombinant expression of terebrid venom peptide from
RT   Terebra guttata.";
RL   Toxins 8:63-63(2016).
CC   -!- FUNCTION: The recombinant protein causes paralysis to polychaete worms
CC       (Nereis virens), the natural prey of terebrid snails.
CC       {ECO:0000269|PubMed:26950153}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:26950153}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305}.
CC   -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C). {ECO:0000305}.
CC   -!- PTM: Contains 3 disulfide bonds. {ECO:0000305}.
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DR   EMBL; KU738608; AML61541.1; -; mRNA.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Disulfide bond; Neurotoxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   PROPEP          17..52
FT                   /evidence="ECO:0000305|PubMed:26950153"
FT                   /id="PRO_0000454647"
FT   CHAIN           53..96
FT                   /note="Teretoxin Tgu6.1"
FT                   /evidence="ECO:0000305|PubMed:26950153"
FT                   /id="PRO_0000454648"
SQ   SEQUENCE   96 AA;  10513 MW;  78FB93DA4BC66D82 CRC64;
     MRPFLVFVLI VSVSLAFSFE DMPNKGGDSV ASITADQARG HKRNPLFPFA QRSLTELKAG
     GCPLYCSSQI FCCHGRKCRN VDGRLKCVTE ASMLGK