ID   T7406_ILLWI             Reviewed;          88 AA.
AC   Q5D228;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   29-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 32.
DE   RecName: Full=U1-hexatoxin-Iw1c;
DE            Short=U1-HXTX-Iw1c;
DE   AltName: Full=Atracotoxin-Hs20f7406 {ECO:0000303|PubMed:15979762};
DE            Short=AcTx-Hs20f7406 {ECO:0000303|PubMed:15979762};
DE   Flags: Precursor; Fragment;
OS   Illawarra wisharti (Illawarra funnel-web spider).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Mygalomorphae; Hexathelidae; Hadronyche; unclassified Hadronyche.
OX   NCBI_TaxID=278061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 42-49, PYROGLUTAMATE
RP   FORMATION AT GLN-18, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom, and Venom gland;
RX   PubMed=15979762; DOI=10.1016/j.peptides.2005.05.012;
RA   Wen S., Wilson D.T., Kuruppu S., Korsinczky M.L., Hedrick J., Pang L.,
RA   Szeto T., Hodgson W.C., Alewood P.F., Nicholson G.M.;
RT   "Discovery of an MIT-like atracotoxin family: spider venom peptides that
RT   share sequence homology but not pharmacological properties with AVIT family
RT   proteins.";
RL   Peptides 26:2412-2426(2005).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15979762}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:15979762}.
CC   -!- SIMILARITY: Belongs to the MIT-like AcTx family. {ECO:0000305}.
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DR   EMBL; AY914168; AAX11348.1; -; mRNA.
DR   AlphaFoldDB; Q5D228; -.
DR   SMR; Q5D228; -.
DR   ArachnoServer; AS000564; U1-hexatoxin-Iw1c.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR020202; Atracotoxin.
DR   Pfam; PF17556; MIT_LIKE_ACTX; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Pyrrolidone carboxylic acid;
KW   Secreted; Signal.
FT   SIGNAL          <1..17
FT   CHAIN           18..85
FT                   /note="U1-hexatoxin-Iw1c"
FT                   /id="PRO_0000265762"
FT   PROPEP          86..88
FT                   /id="PRO_0000265763"
FT   MOD_RES         18
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:15979762"
FT   DISULFID        20..31
FT                   /evidence="ECO:0000305|PubMed:15979762"
FT   DISULFID        25..39
FT                   /evidence="ECO:0000305|PubMed:15979762"
FT   DISULFID        30..65
FT                   /evidence="ECO:0000305|PubMed:15979762"
FT   DISULFID        49..73
FT                   /evidence="ECO:0000305|PubMed:15979762"
FT   DISULFID        67..80
FT                   /evidence="ECO:0000305|PubMed:15979762"
FT   NON_TER         1
SQ   SEQUENCE   88 AA;  9596 MW;  D60799EA05234994 CRC64;
     LKFVVLICLV IMASTSAQQC GDETCGAGTC CAVFSQNHCR RLSQMYDLCS DHSDASPSGN
     YLFFCPCEPG LHCDRNTWTC TEGSSRSE