ID   T7512_HADIN             Reviewed;          90 AA.
AC   Q5D233;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   29-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=U1-hexatoxin-Hi1a;
DE            Short=U1-HXTX-Hi1a;
DE   AltName: Full=Atracotoxin-Hi:OBf7512;
DE            Short=AcTx-Hi:OBf7512;
DE   Flags: Precursor;
OS   Hadronyche infensa (Fraser island funnel-web spider) (Atrax infensus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Mygalomorphae; Hexathelidae; Hadronyche.
OX   NCBI_TaxID=153481;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PYROGLUTAMATE FORMATION AT GLN-19.
RC   TISSUE=Venom, and Venom gland;
RX   PubMed=15979762; DOI=10.1016/j.peptides.2005.05.012;
RA   Wen S., Wilson D.T., Kuruppu S., Korsinczky M.L., Hedrick J., Pang L.,
RA   Szeto T., Hodgson W.C., Alewood P.F., Nicholson G.M.;
RT   "Discovery of an MIT-like atracotoxin family: spider venom peptides that
RT   share sequence homology but not pharmacological properties with AVIT family
RT   proteins.";
RL   Peptides 26:2412-2426(2005).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- SIMILARITY: Belongs to the MIT-like AcTx family. {ECO:0000305}.
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DR   EMBL; AY914163; AAX11343.1; -; mRNA.
DR   AlphaFoldDB; Q5D233; -.
DR   SMR; Q5D233; -.
DR   ArachnoServer; AS000646; U1-hexatoxin-Hi1a.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR020202; Atracotoxin.
DR   Pfam; PF17556; MIT_LIKE_ACTX; 1.
PE   1: Evidence at protein level;
KW   Disulfide bond; Pyrrolidone carboxylic acid; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..86
FT                   /note="U1-hexatoxin-Hi1a"
FT                   /id="PRO_0000265760"
FT   PROPEP          89..90
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000265761"
FT   MOD_RES         19
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:15979762"
FT   DISULFID        21..32
FT                   /evidence="ECO:0000305|PubMed:15979762"
FT   DISULFID        26..40
FT                   /evidence="ECO:0000305|PubMed:15979762"
FT   DISULFID        31..66
FT                   /evidence="ECO:0000305|PubMed:15979762"
FT   DISULFID        50..74
FT                   /evidence="ECO:0000305|PubMed:15979762"
FT   DISULFID        68..81
FT                   /evidence="ECO:0000305|PubMed:15979762"
SQ   SEQUENCE   90 AA;  9956 MW;  78F727C78648D20D CRC64;
     MLKFAVLCFL VIMASTFAQK CGDQVCGAGT CCAEYPEIHC KRVGQLYDIC VDSEATKDSG
     NHLFFCPCDE GMYCDMNSWS CQKKTSGRSE