ID   T7L1B_DANRE             Reviewed;         551 AA.
AC   Q800Q5;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Transcription factor 7-like 1-B;
DE   AltName: Full=HMG box transcription factor 3-B;
DE            Short=TCF-3-B;
GN   Name=tcf7l1b; Synonyms=tcf3b;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DEVELOPMENTAL STAGE.
RX   PubMed=12642497; DOI=10.1242/dev.00402;
RA   Dorsky R.I., Itoh M., Moon R.T., Chitnis A.;
RT   "Two tcf3 genes cooperate to pattern the zebrafish brain.";
RL   Development 130:1937-1947(2003).
RN   [2]
RP   FUNCTION.
RX   PubMed=15151990; DOI=10.1242/dev.01171;
RA   Thorpe C.J., Moon R.T.;
RT   "nemo-like kinase is an essential co-activator of Wnt signaling during
RT   early zebrafish development.";
RL   Development 131:2899-2909(2004).
RN   [3]
RP   FUNCTION.
RX   PubMed=15366005; DOI=10.1002/dvdy.20133;
RA   Riley B.B., Chiang M.-Y., Storch E.M., Heck R., Buckles G.R., Lekven A.C.;
RT   "Rhombomere boundaries are Wnt signaling centers that regulate metameric
RT   patterning in the zebrafish hindbrain.";
RL   Dev. Dyn. 231:278-291(2004).
RN   [4]
RP   FUNCTION.
RX   PubMed=15659486; DOI=10.1242/dev.01616;
RA   Amoyel M., Cheng Y.-C., Jiang Y.-J., Wilkinson D.G.;
RT   "Wnt1 regulates neurogenesis and mediates lateral inhibition of boundary
RT   cell specification in the zebrafish hindbrain.";
RL   Development 132:775-785(2005).
CC   -!- FUNCTION: Participates in the Wnt signaling pathway. Probably binds to
CC       DNA and acts as a repressor in the absence of ctnnb1, and possibly as
CC       an activator in its presence. Regulates anterior-posterior patterning
CC       in the neuroectoderm by repressing posterior neural fates. Also
CC       required for hindbrain morphogenesis. {ECO:0000269|PubMed:12642497,
CC       ECO:0000269|PubMed:15151990, ECO:0000269|PubMed:15366005,
CC       ECO:0000269|PubMed:15659486}.
CC   -!- SUBUNIT: Interacts with ctnnb1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
CC   -!- DEVELOPMENTAL STAGE: Expressed maternally and throughout embryogenesis.
CC       Expressed in the rostral neuroectoderm and at low levels in the
CC       notochord following gastrulation. Expressed throughout the developing
CC       brain during somitogenesis. {ECO:0000269|PubMed:12642497}.
CC   -!- SIMILARITY: Belongs to the TCF/LEF family. {ECO:0000305}.
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DR   EMBL; AY221031; AAO65958.1; -; mRNA.
DR   AlphaFoldDB; Q800Q5; -.
DR   SMR; Q800Q5; -.
DR   STRING; 7955.ENSDARP00000051824; -.
DR   PaxDb; Q800Q5; -.
DR   ZFIN; ZDB-GENE-991110-10; tcf7l1b.
DR   eggNOG; KOG3248; Eukaryota.
DR   InParanoid; Q800Q5; -.
DR   PhylomeDB; Q800Q5; -.
DR   PRO; PR:Q800Q5; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:1990907; C:beta-catenin-TCF complex; IBA:GO_Central.
DR   GO; GO:0008013; F:beta-catenin binding; IEA:InterPro.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0035284; P:brain segmentation; IMP:ZFIN.
DR   GO; GO:0060070; P:canonical Wnt signaling pathway; IBA:GO_Central.
DR   GO; GO:0010456; P:cell proliferation in dorsal spinal cord; IGI:ZFIN.
DR   GO; GO:0009880; P:embryonic pattern specification; IMP:ZFIN.
DR   GO; GO:0060847; P:endothelial cell fate specification; IMP:ZFIN.
DR   GO; GO:0048699; P:generation of neurons; IGI:ZFIN.
DR   GO; GO:0007507; P:heart development; IMP:ZFIN.
DR   GO; GO:0030902; P:hindbrain development; IMP:ZFIN.
DR   GO; GO:0030901; P:midbrain development; IMP:ZFIN.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IGI:ZFIN.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IGI:ZFIN.
DR   GO; GO:0021903; P:rostrocaudal neural tube patterning; IMP:ZFIN.
DR   Gene3D; 1.10.30.10; -; 1.
DR   Gene3D; 4.10.900.10; -; 1.
DR   InterPro; IPR027397; Catenin-bd_sf.
DR   InterPro; IPR013558; CTNNB1-bd_N.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   InterPro; IPR024940; TCF/LEF.
DR   InterPro; IPR028778; Tcf7l1.
DR   PANTHER; PTHR10373; PTHR10373; 1.
DR   PANTHER; PTHR10373:SF25; PTHR10373:SF25; 1.
DR   Pfam; PF08347; CTNNB1_binding; 1.
DR   Pfam; PF00505; HMG_box; 1.
DR   SMART; SM00398; HMG; 1.
DR   SUPFAM; SSF47095; SSF47095; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
PE   2: Evidence at transcript level;
KW   Activator; Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW   Repressor; Transcription; Transcription regulation; Wnt signaling pathway.
FT   CHAIN           1..551
FT                   /note="Transcription factor 7-like 1-B"
FT                   /id="PRO_0000048622"
FT   DNA_BIND        326..394
FT                   /note="HMG box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT   REGION          1..76
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          298..326
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          392..525
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        16..46
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        47..63
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        488..508
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   551 AA;  60418 MW;  F66980E167AD9FF9 CRC64;
     MPQLNGGGGD ELGANDEMIS FKDEGEQEDK ISENVSAERG LDDVKSSLVS ESENNSSSSD
     SEQTERRPQP RADLESYEKA REYFTEALRR QQDGGFFKSP HYPGYPFLMI PDLANPYLSN
     GALSPSARTY LQMKWPLLDV PGSAALKDSQ SPSPGHLSNK VPVVQHAHMH PLTPLITYSN
     EFPPGTPPAH LSPEILDPKT GIPRTPHPAE LSPYYPLSPG TVGQIPHPLG WLVPQQGQHM
     YPITAGGFRH PYPALAMNAS MSSLVSSRFS PHLVPHHPHG LHQTGIPHPA IVSPVIKQEP
     NGELSPPVNT KSPGPNKKDE DKKPHIKKPL NAFMLYMKEM RAKVVAECTL KENAAINQIL
     GRRWHSLSRE EQAKYYELAR KERQLHSQLY PGWSARDNYG KRKKRKRDNK TDSTPEDFSM
     RSKKPCVQYL PQEKMIDSPG SSHGSMLDSP ATPSAALASP AAPAATHSEQ AQPLSLTTKP
     ERFPLLSKPP PSSSSSSSSS SSSGLPTPPL LSRPLPFALL TPPSPFHQAA LHSHHALFQS
     QPLSLVTKSS D