ID   T7L1B_XENLA             Reviewed;         551 AA.
AC   Q90ZB6; Q6DD63;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Transcription factor 7-like 1-B;
DE   AltName: Full=HMG box transcription factor 3-B;
DE            Short=TCF-3-B;
DE            Short=xTcf-3;
GN   Name=tcf7l1-b; Synonyms=tcf3, tcf3b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DNA-BINDING, AND INTERACTION WITH
RP   TLE1-B.
RX   PubMed=11124256; DOI=10.1074/jbc.m007533200;
RA   Pukrop T., Gradl D., Henningfeld K.A., Knoechel W., Wedlich D., Kuehl M.;
RT   "Identification of two regulatory elements within the high mobility group
RT   box transcription factor XTCF-4.";
RL   J. Biol. Chem. 276:8968-8978(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   FUNCTION.
RX   PubMed=10409747; DOI=10.1128/mcb.19.8.5576;
RA   Gradl D., Kuehl M., Wedlich D.;
RT   "The Wnt/Wg signal transducer beta-catenin controls fibronectin
RT   expression.";
RL   Mol. Cell. Biol. 19:5576-5587(1999).
RN   [4]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=11821382; DOI=10.1074/jbc.m107055200;
RA   Gradl D., Koenig A., Wedlich D.;
RT   "Functional diversity of Xenopus lymphoid enhancer factor/T-cell factor
RT   transcription factors relies on combinations of activating and repressing
RT   elements.";
RL   J. Biol. Chem. 277:14159-14171(2002).
CC   -!- FUNCTION: Participates in the Wnt signaling pathway. Binds to DNA and
CC       acts as a repressor in the absence of ctnnb1-A and possibly ctnnb1-B,
CC       and as an activator in the presence of these proteins. Required early
CC       in development for the establishment of the dorsal body axis in
CC       response to maternal Wnt signaling. {ECO:0000269|PubMed:10409747,
CC       ECO:0000269|PubMed:11124256, ECO:0000269|PubMed:11821382}.
CC   -!- SUBUNIT: Interacts with csnk1e, ctnnb1-A, ctbp-B, dact1-A and gsk3b.
CC       May interact with ase and tle4-A (By similarity). Interacts with tle1-
CC       B. {ECO:0000250, ECO:0000269|PubMed:11124256}.
CC   -!- INTERACTION:
CC       Q90ZB6; Q7T103: pou5f1.1; NbExp=3; IntAct=EBI-7439087, EBI-7438970;
CC       Q90ZB6; P87377: vegt-a; NbExp=4; IntAct=EBI-7439087, EBI-7439000;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267,
CC       ECO:0000269|PubMed:11821382}.
CC   -!- PTM: Phosphorylated. Phosphorylation by csnk1e promotes binding to
CC       ctnnb1-A while phosphorylation by gsk3b may reverse this effect (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TCF/LEF family. {ECO:0000305}.
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DR   EMBL; AF287149; AAK58835.1; -; mRNA.
DR   EMBL; BC077764; AAH77764.1; -; mRNA.
DR   RefSeq; NP_001080938.1; NM_001087469.2.
DR   AlphaFoldDB; Q90ZB6; -.
DR   SMR; Q90ZB6; -.
DR   IntAct; Q90ZB6; 4.
DR   MINT; Q90ZB6; -.
DR   DNASU; 394281; -.
DR   GeneID; 394281; -.
DR   KEGG; xla:394281; -.
DR   CTD; 394281; -.
DR   Xenbase; XB-GENE-1031992; tcf7l1.S.
DR   OMA; YTHTIRN; -.
DR   OrthoDB; 807716at2759; -.
DR   Proteomes; UP000186698; Chromosome 3S.
DR   Bgee; 394281; Expressed in blastula and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0008013; F:beta-catenin binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0060070; P:canonical Wnt signaling pathway; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   Gene3D; 1.10.30.10; -; 1.
DR   Gene3D; 4.10.900.10; -; 1.
DR   InterPro; IPR027397; Catenin-bd_sf.
DR   InterPro; IPR013558; CTNNB1-bd_N.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   InterPro; IPR024940; TCF/LEF.
DR   InterPro; IPR028778; Tcf7l1.
DR   PANTHER; PTHR10373; PTHR10373; 1.
DR   PANTHER; PTHR10373:SF25; PTHR10373:SF25; 1.
DR   Pfam; PF08347; CTNNB1_binding; 1.
DR   Pfam; PF00505; HMG_box; 1.
DR   SMART; SM00398; HMG; 1.
DR   SUPFAM; SSF47095; SSF47095; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
PE   1: Evidence at protein level;
KW   Activator; Developmental protein; DNA-binding; Nucleus; Phosphoprotein;
KW   Reference proteome; Repressor; Transcription; Transcription regulation;
KW   Wnt signaling pathway.
FT   CHAIN           1..551
FT                   /note="Transcription factor 7-like 1-B"
FT                   /id="PRO_0000048617"
FT   DNA_BIND        324..392
FT                   /note="HMG box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT   REGION          1..77
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1..61
FT                   /note="Interaction with CTNNB1-A"
FT                   /evidence="ECO:0000250"
FT   REGION          109..312
FT                   /note="Interaction with AES and TLE4-A"
FT                   /evidence="ECO:0000250"
FT   REGION          183..213
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          391..474
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          408..551
FT                   /note="Interaction with CTBP-B"
FT                   /evidence="ECO:0000250"
FT   REGION          492..515
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        15..36
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        55..77
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        196..210
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        430..445
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        203..222
FT                   /note="Missing (in Ref. 2; AAH77764)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   551 AA;  59962 MW;  A32111DE57877AFE CRC64;
     MPQLNSGGGD ELGANDELIR FKDEGEQEEK SPGEGSAEGD LADVKSSLVN ESENHSSDSD
     SEVERRPPPR ETFEKPRDYL SEAFRRQQDA AFFKGPPYAG YPFLMIPDLG GHYLPNGALS
     PSARAYLQMK WPLLDSPSTA GLKDARSPSP AHLSNKVPVV QHPHHMHPLT PLITYSNEHF
     SPGTPPGHLS PEIDPKTGIP RPPHPSELSP YYPLSPGAVG QIPHPLGWLV PQQGQPMYSI
     PPGGFRHPYP ALAMNASMSS LVSSRFSPHM VPPPHHSLHT SGIPHPAIVS PIVKQEPSSG
     NISPNLSTKS NVVVKKEEEK KPHIKKPLNA FMLYMKEMRA KVVAECTLKE SAAINQILGR
     RWHSLSREEQ AKYYELARKE RQLHSQLYPS WSARDNYGKK KKRKREKQSP EMENYTKTKK
     MCVQHFPSDK SCDSPASSHG SMLDSPATPS AALASPAAPA ATHSEQAQPL SLTTKPEARA
     LSHSAAFLAS KSPSSSSLSG HLPSPVGSPL LSRPIPLTSS ILSPPGVFPS ALQALPLLQA
     QPLSLVTRSS D