ID   T904_LACLA              Reviewed;         253 AA.
AC   P35878; Q03204;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=Transposase for insertion sequence element IS904;
GN   Name=nisX1; OrderedLocusNames=LL0137; ORFNames=L0458;
GN   and
GN   Name=nisX2; OrderedLocusNames=LL0140; ORFNames=L0459;
GN   and
GN   Name=nisX3; OrderedLocusNames=LL0637; ORFNames=L0461;
GN   and
GN   Name=nisX4; OrderedLocusNames=LL0822; ORFNames=L0462;
GN   and
GN   Name=nisX5; OrderedLocusNames=LL2145; ORFNames=L0465;
OS   Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus.
OX   NCBI_TaxID=272623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2118169; DOI=10.1099/00221287-136-3-555;
RA   Dodd H.M., Horn N., Gasson M.J.;
RT   "Analysis of the genetic determinant for production of the peptide
RT   antibiotic nisin.";
RL   J. Gen. Microbiol. 136:555-566(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1482189; DOI=10.1128/aem.58.11.3683-3693.1992;
RA   Dodd H.M., Horn N., Gasson M.J.;
RT   "A lactococcal expression system for engineered nisins.";
RL   Appl. Environ. Microbiol. 58:3683-3693(1992).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Araya T.;
RL   Submitted (AUG-1992) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IL1403;
RX   PubMed=11337471; DOI=10.1101/gr.gr-1697r;
RA   Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J.,
RA   Ehrlich S.D., Sorokin A.;
RT   "The complete genome sequence of the lactic acid bacterium Lactococcus
RT   lactis ssp. lactis IL1403.";
RL   Genome Res. 11:731-753(2001).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 146-253.
RC   STRAIN=6F3;
RX   PubMed=1482192; DOI=10.1128/aem.58.11.3730-3743.1992;
RA   Engelke G., Gutowski-Eckel Z., Hammelmann M., Entian K.-D.;
RT   "Biosynthesis of the lantibiotic nisin: genomic organization and membrane
RT   localization of the NisB protein.";
RL   Appl. Environ. Microbiol. 58:3730-3743(1992).
CC   -!- FUNCTION: Involved in the transposition of the insertion sequence.
CC   -!- SIMILARITY: Belongs to the transposase IS3/IS150/IS904 family.
CC       {ECO:0000305}.
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DR   EMBL; M27276; AAA25194.1; -; Genomic_DNA.
DR   EMBL; M79445; AAA25197.1; -; Genomic_DNA.
DR   EMBL; D00696; BAA00601.1; -; Genomic_DNA.
DR   EMBL; AE005176; AAK04235.1; -; Genomic_DNA.
DR   EMBL; AE005176; AAK04238.1; -; Genomic_DNA.
DR   EMBL; AE005176; AAK04735.1; -; Genomic_DNA.
DR   EMBL; AE005176; AAK04920.1; -; Genomic_DNA.
DR   EMBL; AE005176; AAK06243.1; -; Genomic_DNA.
DR   EMBL; X68307; CAA48379.1; -; Genomic_DNA.
DR   PIR; A45821; A45821.
DR   PIR; F86727; F86727.
DR   RefSeq; NP_266293.1; NC_002662.1.
DR   RefSeq; NP_266296.1; NC_002662.1.
DR   RefSeq; NP_266793.1; NC_002662.1.
DR   RefSeq; NP_266978.1; NC_002662.1.
DR   RefSeq; NP_268302.1; NC_002662.1.
DR   AlphaFoldDB; P35878; -.
DR   SMR; P35878; -.
DR   STRING; 272623.L0458; -.
DR   PaxDb; P35878; -.
DR   EnsemblBacteria; AAK04235; AAK04235; L0458.
DR   EnsemblBacteria; AAK04238; AAK04238; L0459.
DR   EnsemblBacteria; AAK04735; AAK04735; L0461.
DR   EnsemblBacteria; AAK04920; AAK04920; L0462.
DR   EnsemblBacteria; AAK06243; AAK06243; L0465.
DR   KEGG; lla:L0458; -.
DR   KEGG; lla:L0459; -.
DR   KEGG; lla:L0461; -.
DR   KEGG; lla:L0462; -.
DR   KEGG; lla:L0465; -.
DR   PATRIC; fig|272623.7.peg.152; -.
DR   eggNOG; COG2801; Bacteria.
DR   HOGENOM; CLU_027402_4_2_9; -.
DR   OMA; IAHYNER; -.
DR   Proteomes; UP000002196; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0032196; P:transposition; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.420.10; -; 1.
DR   InterPro; IPR025948; HTH-like_dom.
DR   InterPro; IPR038965; InsF-like.
DR   InterPro; IPR001584; Integrase_cat-core.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   PANTHER; PTHR46889:SF1; PTHR46889:SF1; 1.
DR   Pfam; PF13276; HTH_21; 1.
DR   Pfam; PF00665; rve; 1.
DR   Pfam; PF13333; rve_2; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS50994; INTEGRASE; 1.
PE   3: Inferred from homology;
KW   DNA recombination; DNA-binding; Reference proteome; Transposable element;
KW   Transposition.
FT   CHAIN           1..253
FT                   /note="Transposase for insertion sequence element IS904"
FT                   /id="PRO_0000075486"
FT   DOMAIN          90..253
FT                   /note="Integrase catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00457"
SQ   SEQUENCE   253 AA;  29394 MW;  D6718A95B0058CA7 CRC64;
     MHRRPSKQQV EREILSEKIK AVFHEHKGRY GAVRITKVLH NTGIMTNTKR VGKLMHLMGL
     YAKGSRYKYK HYNRKGASLS RPNLINQIFK ATAPNKVWLG DMTYIPTKEG TLYLAVNIDV
     FSRKIVGWSM SSRMQDKLVR DCFLQACGKE HPQPGLIVHT DQGSQYTSSR YQSTLRQVGA
     QSSMSRKGNP YDNAMMESFY KTLKRELIND AHFETRAEAT QEIFKYIETY YNTKRMHSGL
     DYKSPKDFEK YNS