TA13C_DANRE
ID TA13C_DANRE Reviewed; 341 AA.
AC Q5QNP2;
DT 19-FEB-2014, integrated into UniProtKB/Swiss-Prot.
DT 04-JAN-2005, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Trace amine-associated receptor 13c {ECO:0000312|ZFIN:ZDB-GENE-041014-60};
GN Name=taar13c {ECO:0000312|Ensembl:ENSDARP00000091296,
GN ECO:0000312|ZFIN:ZDB-GENE-041014-60};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1] {ECO:0000312|Ensembl:ENSDARP00000091296}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000312|Ensembl:ENSDARP00000091296};
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2] {ECO:0000305}
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=24218586; DOI=10.1073/pnas.1318596110;
RA Hussain A., Saraiva L.R., Ferrero D.M., Ahuja G., Krishna V.S.,
RA Liberles S.D., Korsching S.I.;
RT "High-affinity olfactory receptor for the death-associated odor
RT cadaverine.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:19579-19584(2013).
CC -!- FUNCTION: Olfactory receptor for medium length odd-chained diamines
CC including cadaverine which is generated by bacterial decarboxylation of
CC the basic amino acid lysine and contributes to the odor of decomposing
CC tissue. Mediates pronounced innate aversion behavior to cadaverine.
CC {ECO:0000269|PubMed:24218586}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O14804};
CC Multi-pass membrane protein {ECO:0000250|UniProtKB:O14804}.
CC -!- TISSUE SPECIFICITY: Expressed in olfactory epithelium (at protein
CC level). Detected in a sparse population of olfactory sensory neurons.
CC {ECO:0000269|PubMed:24218586}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AL929507; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001076509.1; NM_001083040.1.
DR AlphaFoldDB; Q5QNP2; -.
DR SMR; Q5QNP2; -.
DR STRING; 7955.ENSDARP00000091296; -.
DR PaxDb; Q5QNP2; -.
DR Ensembl; ENSDART00000100523; ENSDARP00000091296; ENSDARG00000112794.
DR Ensembl; ENSDART00000185587; ENSDARP00000154267; ENSDARG00000112626.
DR Ensembl; ENSDART00000187307; ENSDARP00000153417; ENSDARG00000116335.
DR GeneID; 100034378; -.
DR KEGG; dre:100034378; -.
DR CTD; 100034378; -.
DR ZFIN; ZDB-GENE-041014-60; taar13c.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00940000161258; -.
DR HOGENOM; CLU_009579_11_0_1; -.
DR InParanoid; Q5QNP2; -.
DR OMA; MEPHINF; -.
DR OrthoDB; 913195at2759; -.
DR PhylomeDB; Q5QNP2; -.
DR TreeFam; TF343107; -.
DR Reactome; R-DRE-375280; Amine ligand-binding receptors.
DR Reactome; R-DRE-418555; G alpha (s) signalling events.
DR PRO; PR:Q5QNP2; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 20.
DR Bgee; ENSDARG00000116335; Expressed in olfactory epithelium.
DR GO; GO:0016021; C:integral component of membrane; IDA:ZFIN.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008227; F:G protein-coupled amine receptor activity; IDA:UniProtKB.
DR GO; GO:0004984; F:olfactory receptor activity; IDA:ZFIN.
DR GO; GO:0019808; F:polyamine binding; IDA:ZFIN.
DR GO; GO:0019810; F:putrescine binding; IDA:ZFIN.
DR GO; GO:0001594; F:trace-amine receptor activity; IBA:GO_Central.
DR GO; GO:0007610; P:behavior; IEA:UniProtKB-KW.
DR GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IEP:ZFIN.
DR GO; GO:1990834; P:response to odorant; IDA:ZFIN.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; IDA:UniProtKB.
DR GO; GO:0009995; P:soluble molecule recognition; IDA:ZFIN.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR009132; TAAR_fam.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01830; TRACEAMINER.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Behavior; Cell membrane; Disulfide bond; G-protein coupled receptor;
KW Glycoprotein; Membrane; Olfaction; Receptor; Reference proteome;
KW Sensory transduction; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..341
FT /note="Trace amine-associated receptor 13c"
FT /id="PRO_0000425538"
FT TOPO_DOM 1..34
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 35..55
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 56..68
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 69..89
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 90..105
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..126
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 127..147
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..168
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 169..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..257
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 258..278
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 279..292
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 293..313
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 314..341
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 19
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 283
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 105..186
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 341 AA; 38441 MW; A511E3DDF389FED5 CRC64;
MDLSSQEYDP SQFCFPAVNN SCLKGTHHVS TQTVVYLILA SAMTVTVLGN SVVIISIAHF
KQLQTPTNIL VMSLALADLL LGLVVMPFSM IRSVDGCWYY GETFCLLHTG FDLFLTSVSI
FHLIFIAVDR HQAVCFPLQY PTRITIPVAW VMVMISWSMA AFYSYGVVYS KANLEGLEEY
IASVYCMGGC TLYFNALWSV LDTLLTFFLP CSVMVGLYAR IFVVAKKHIK SITEANQNEN
ENVFKNPRRS ERKAAKTLGI VVGAFILCWL PFFINSLVDP YINFSTPYAL FDAFGWLGYT
NSTLNPIIYG LFYPWFRKTL SLIVTLRIFE PNSSDINLFT V
