ID   TA15_TREPA              Reviewed;         141 AA.
AC   P16055; O83201;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 1.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=15 kDa lipoprotein;
DE   AltName: Full=Major membrane immunogen;
DE   Flags: Precursor;
GN   Name=tpp15; OrderedLocusNames=TP_0171;
OS   Treponema pallidum (strain Nichols).
OC   Bacteria; Spirochaetes; Spirochaetales; Treponemataceae; Treponema.
OX   NCBI_TaxID=243276;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2280688; DOI=10.1111/j.1365-2958.1990.tb00716.x;
RA   Purcell B.K., Radolf J.D.;
RT   "Lipid modification of the 15 kilodalton major membrane immunogen of
RT   Treponema pallidum.";
RL   Mol. Microbiol. 4:1371-1379(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9332349; DOI=10.1016/s0378-1119(97)00234-5;
RA   Hardham J.M., Stamm L.V., Porcella S.F., Frye J.G., Barnes N.Y.,
RA   Howell J.K., Mueller S.L., Radolf J.D., Weinstock G.M., Norris S.J.;
RT   "Identification and transcriptional analysis of a Treponema pallidum operon
RT   encoding a putative ABC transport system, an iron-activated repressor
RT   protein homolog, and a glycolytic pathway enzyme homolog.";
RL   Gene 197:47-64(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nichols;
RX   PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA   Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA   Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA   Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M., Utterback T.R.,
RA   McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A.,
RA   Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O.,
RA   Venter J.C.;
RT   "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL   Science 281:375-388(1998).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC       {ECO:0000305}.
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DR   EMBL; U55214; AAC45732.1; -; Genomic_DNA.
DR   EMBL; AE000520; AAC65160.1; -; Genomic_DNA.
DR   AlphaFoldDB; P16055; -.
DR   SMR; P16055; -.
DR   IntAct; P16055; 17.
DR   STRING; 243276.TPANIC_0171; -.
DR   EnsemblBacteria; AAC65160; AAC65160; TP_0171.
DR   KEGG; tpa:TP_0171; -.
DR   eggNOG; COG4939; Bacteria.
DR   HOGENOM; CLU_119924_1_0_12; -.
DR   OMA; HGYKGQI; -.
DR   Proteomes; UP000000811; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR   InterPro; IPR007329; FMN-bd.
DR   InterPro; IPR017058; Major_M_immunogen_Tpp15_prd.
DR   Pfam; PF04205; FMN_bind; 1.
DR   PIRSF; PIRSF036531; Tpp15_prd; 1.
DR   SMART; SM00900; FMN_bind; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   4: Predicted;
KW   Cell membrane; Lipoprotein; Membrane; Palmitate; Reference proteome;
KW   Signal.
FT   SIGNAL          1..17
FT   CHAIN           18..141
FT                   /note="15 kDa lipoprotein"
FT                   /id="PRO_0000018199"
FT   LIPID           18
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000305"
FT   LIPID           18
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        6
FT                   /note="R -> GA (in Ref. 3)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        124
FT                   /note="R -> A (in Ref. 3; AAC65160)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   141 AA;  15783 MW;  BC00878646EADCF5 CRC64;
     MVKRGRFALC LAVLLGACSF SSIPNGTYRA TYQDFDENGW KDFLEVTFDG GKMVQVVYDY
     QHKEGRFKSQ DADYHRVMYA SSGIGPEKAF RELADALLEK GNPEMVDVVT GATVSSQSFR
     RLGRALLQSA RRGEKEAIIS R