ID   TA17_TREPA              Reviewed;         156 AA.
AC   P29722;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   25-MAY-2022, entry version 112.
DE   RecName: Full=17 kDa lipoprotein;
DE   Flags: Precursor;
GN   Name=tpp17; OrderedLocusNames=TP_0435;
OS   Treponema pallidum (strain Nichols).
OC   Bacteria; Spirochaetes; Spirochaetales; Treponemataceae; Treponema.
OX   NCBI_TaxID=243276;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8454324; DOI=10.1128/iai.61.4.1202-1210.1993;
RA   Akins D.R., Purcell B.K., Mitra M.M., Norgard M.V., Radolf J.D.;
RT   "Lipid modification of the 17-kilodalton membrane immunogen of Treponema
RT   pallidum determines macrophage activation as well as amphiphilicity.";
RL   Infect. Immun. 61:1202-1210(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nichols;
RX   PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA   Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA   Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA   Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M., Utterback T.R.,
RA   McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A.,
RA   Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O.,
RA   Venter J.C.;
RT   "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL   Science 281:375-388(1998).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC       {ECO:0000305}.
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DR   EMBL; M74825; AAA27472.1; -; Genomic_DNA.
DR   EMBL; AE000520; AAC65423.1; -; Genomic_DNA.
DR   PIR; C71323; C71323.
DR   RefSeq; WP_010881883.1; NC_021490.2.
DR   PDB; 4U3Q; X-ray; 2.40 A; A/B=33-154.
DR   PDBsum; 4U3Q; -.
DR   AlphaFoldDB; P29722; -.
DR   SMR; P29722; -.
DR   IntAct; P29722; 18.
DR   STRING; 243276.TPANIC_0435; -.
DR   EnsemblBacteria; AAC65423; AAC65423; TP_0435.
DR   GeneID; 57878959; -.
DR   KEGG; tpa:TP_0435; -.
DR   eggNOG; COG3015; Bacteria.
DR   HOGENOM; CLU_1685798_0_0_12; -.
DR   OrthoDB; 2029962at2; -.
DR   Proteomes; UP000000811; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR007298; Cu-R_lipoprotein_NlpE.
DR   Pfam; PF04170; NlpE; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cell membrane; Lipoprotein; Membrane; Palmitate;
KW   Reference proteome; Signal.
FT   SIGNAL          1..21
FT   CHAIN           22..156
FT                   /note="17 kDa lipoprotein"
FT                   /id="PRO_0000018200"
FT   LIPID           22
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000305"
FT   LIPID           22
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000305"
FT   HELIX           35..44
FT                   /evidence="ECO:0007829|PDB:4U3Q"
FT   STRAND          47..52
FT                   /evidence="ECO:0007829|PDB:4U3Q"
FT   STRAND          62..67
FT                   /evidence="ECO:0007829|PDB:4U3Q"
FT   STRAND          71..78
FT                   /evidence="ECO:0007829|PDB:4U3Q"
FT   STRAND          89..97
FT                   /evidence="ECO:0007829|PDB:4U3Q"
FT   STRAND          99..101
FT                   /evidence="ECO:0007829|PDB:4U3Q"
FT   STRAND          103..108
FT                   /evidence="ECO:0007829|PDB:4U3Q"
FT   STRAND          119..126
FT                   /evidence="ECO:0007829|PDB:4U3Q"
FT   STRAND          129..136
FT                   /evidence="ECO:0007829|PDB:4U3Q"
FT   HELIX           146..149
FT                   /evidence="ECO:0007829|PDB:4U3Q"
FT   STRAND          150..153
FT                   /evidence="ECO:0007829|PDB:4U3Q"
SQ   SEQUENCE   156 AA;  16467 MW;  03630A2AACEA13F7 CRC64;
     MKGSVRALCA FLGVGALGSA LCVSCTTVCP HAGKAKAEKV ECALKGGIFR GTLPAADCPG
     IDTTVTFNAD GTAQKVELAL EKKSAPSPLT YRGTWMVRED GIVELSLVSS EQSKAPHEKE
     LYELIDSNSV RYMGAPGAGK PSKEMAPFYV LKKTKK