TA1_ARATH
ID TA1_ARATH Reviewed; 172 AA.
AC Q9SR34;
DT 05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Transcriptional regulator TAC1;
DE AltName: Full=Protein TELOMERASE ACTIVATOR1;
GN Name=TAC1; OrderedLocusNames=At3g09290; ORFNames=F3L24.16;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Fujita M., Mizukado S., Seki M., Shinozaki K., Mitsuda N., Takiguchi Y.,
RA Takagi M.;
RT "ORF cloning and analysis of Arabidopsis transcription factor genes.";
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP FUNCTION, DOMAIN EAR-LIKE, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX PubMed=15486103; DOI=10.1105/tpc.104.025072;
RA Ren S., Johnston J.S., Shippen D.E., McKnight T.D.;
RT "TELOMERASE ACTIVATOR1 induces telomerase activity and potentiates
RT responses to auxin in Arabidopsis.";
RL Plant Cell 16:2910-2922(2004).
RN [5]
RP FUNCTION.
RX PubMed=17220202; DOI=10.1105/tpc.106.044321;
RA Ren S., Mandadi K.K., Boedeker A.L., Rathore K.S., McKnight T.D.;
RT "Regulation of telomerase in Arabidopsis by BT2, an apparent target of
RT TELOMERASE ACTIVATOR1.";
RL Plant Cell 19:23-31(2007).
CC -!- FUNCTION: Activation factor which mediates telomerase activity and
CC potentiates responses to auxin through the regulation of BT2. Binds in
CC vitro to the DNA sequence 5'-GACAGTGTTAC-3' of the BT2 promoter.
CC {ECO:0000269|PubMed:15486103, ECO:0000269|PubMed:17220202}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Preferentially expressed in roots and flowers.
CC Slightly expressed in leaves and stems. {ECO:0000269|PubMed:15486103}.
CC -!- DOMAIN: Contains a slightly degenerated ERF-associated amphiphilic
CC repression (EAR) motif, which may be involved in the activity of
CC transcriptional repression. {ECO:0000250}.
CC -!- DISRUPTION PHENOTYPE: Altered response to auxin, but persistance of the
CC telomerase activity. {ECO:0000269|PubMed:15486103}.
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DR EMBL; AC011436; AAF14043.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE74747.1; -; Genomic_DNA.
DR EMBL; AB493607; BAH30445.1; -; mRNA.
DR RefSeq; NP_187540.1; NM_111763.2.
DR AlphaFoldDB; Q9SR34; -.
DR SMR; Q9SR34; -.
DR BioGRID; 5419; 6.
DR IntAct; Q9SR34; 6.
DR STRING; 3702.AT3G09290.1; -.
DR PaxDb; Q9SR34; -.
DR PRIDE; Q9SR34; -.
DR ProteomicsDB; 234115; -.
DR EnsemblPlants; AT3G09290.1; AT3G09290.1; AT3G09290.
DR GeneID; 820085; -.
DR Gramene; AT3G09290.1; AT3G09290.1; AT3G09290.
DR KEGG; ath:AT3G09290; -.
DR Araport; AT3G09290; -.
DR TAIR; locus:2083574; AT3G09290.
DR eggNOG; ENOG502S768; Eukaryota.
DR HOGENOM; CLU_068782_2_0_1; -.
DR InParanoid; Q9SR34; -.
DR OMA; RIPRNSH; -.
DR OrthoDB; 1450809at2759; -.
DR PhylomeDB; Q9SR34; -.
DR PRO; PR:Q9SR34; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9SR34; baseline and differential.
DR Genevisible; Q9SR34; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IMP:TAIR.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0051973; P:positive regulation of telomerase activity; IGI:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..172
FT /note="Transcriptional regulator TAC1"
FT /id="PRO_0000406148"
FT ZN_FING 35..57
FT /note="C2H2-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 156..160
FT /note="EAR-like (transcriptional repression)"
FT /evidence="ECO:0000250"
FT COMPBIAS 10..28
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 172 AA; 19331 MW; 839AEE438E0B6461 CRC64;
MENIKNPKNA DDCSDSISKN SHQGVDDSLN QSRSYVCSFC IRGFSNAQAL GGHMNIHRRD
RAKLRQKLME DNKDDVVAES DASEVVSLDL NEQQQQQGEA LTCDDHDQYV DNDISPKQKL
EFWVQESKLD TNDHGKVTEA SIDGSSSSHH RDIEVLDLEL RLGQSVVKKK TT
