TA2GV_AGEOR
ID TA2GV_AGEOR Reviewed; 63 AA.
AC P0CF15;
DT 20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT 20-APR-2010, sequence version 1.
DT 25-MAY-2022, entry version 17.
DE RecName: Full=U2-agatoxin-Ao1v;
DE Short=U2-AGTX-Ao1v;
DE AltName: Full=Agel_21;
DE Flags: Precursor; Fragment;
OS Agelena orientalis (Funnel-web spider).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC Araneomorphae; Entelegynae; Agelenidae; Agelena.
OX NCBI_TaxID=293813;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Venom gland;
RX PubMed=15688451; DOI=10.1002/prot.20390;
RA Kozlov S.A., Malyavka A., McCutchen B., Lu A., Schepers E., Herrmann R.,
RA Grishin E.V.;
RT "A novel strategy for the identification of toxinlike structures in spider
RT venom.";
RL Proteins 59:131-140(2005).
CC -!- FUNCTION: Insect active toxin causing rapid but reversible paralysis in
CC crickets. No activity shown in mammals. Does not show effect on
CC mammalian voltage-gated calcium channels (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC structurally defines this protein as a knottin. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the neurotoxin 01 (U2-agtx) family.
CC {ECO:0000305}.
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DR AlphaFoldDB; P0CF15; -.
DR SMR; P0CF15; -.
DR ArachnoServer; AS000772; U2-agatoxin-Ao1v.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE 2: Evidence at transcript level;
KW Disulfide bond; Knottin; Neurotoxin; Secreted; Signal; Toxin.
FT SIGNAL <1..14
FT /evidence="ECO:0000255"
FT PROPEP 15..28
FT /evidence="ECO:0000255"
FT /id="PRO_0000393361"
FT CHAIN 29..63
FT /note="U2-agatoxin-Ao1v"
FT /id="PRO_0000393362"
FT DISULFID 31..47
FT /evidence="ECO:0000250"
FT DISULFID 38..52
FT /evidence="ECO:0000250"
FT DISULFID 46..62
FT /evidence="ECO:0000250"
FT NON_TER 1
SQ SEQUENCE 63 AA; 6767 MW; 24DBF1A78AF0B301 CRC64;
LLLISAMVGS MIAAVPEEES LQLSEDERGG CLPHNRFCNA LSGPRCCSGL TCKELNIWAS
KCL