TA2R1_HUMAN
ID TA2R1_HUMAN Reviewed; 299 AA.
AC Q9NYW7; Q646G8;
DT 11-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Taste receptor type 2 member 1;
DE Short=T2R1;
DE AltName: Full=Taste receptor family B member 7;
DE Short=TRB7;
GN Name=TAS2R1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TOPOLOGY.
RX PubMed=10761934; DOI=10.1016/s0092-8674(00)80705-9;
RA Adler E., Hoon M.A., Mueller K.L., Chandrashekar J., Ryba N.J.P.,
RA Zuker C.S.;
RT "A novel family of mammalian taste receptors.";
RL Cell 100:693-702(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=15496549; DOI=10.1093/molbev/msi027;
RA Fischer A., Gilad Y., Man O., Paeaebo S.;
RT "Evolution of bitter taste receptors in humans and apes.";
RL Mol. Biol. Evol. 22:432-436(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain cortex;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP CHARACTERIZATION.
RX PubMed=10761935; DOI=10.1016/s0092-8674(00)80706-0;
RA Chandrashekar J., Mueller K.L., Hoon M.A., Adler E., Feng L., Guo W.,
RA Zuker C.S., Ryba N.J.P.;
RT "T2Rs function as bitter taste receptors.";
RL Cell 100:703-711(2000).
RN [5]
RP REVIEW.
RX PubMed=12139982; DOI=10.1016/s0959-4388(02)00345-8;
RA Montmayeur J.-P., Matsunami H.;
RT "Receptors for bitter and sweet taste.";
RL Curr. Opin. Neurobiol. 12:366-371(2002).
RN [6]
RP REVIEW.
RX PubMed=11696554; DOI=10.1074/jbc.r100054200;
RA Margolskee R.F.;
RT "Molecular mechanisms of bitter and sweet taste transduction.";
RL J. Biol. Chem. 277:1-4(2002).
RN [7]
RP REVIEW.
RX PubMed=12581520; DOI=10.1016/s0092-8674(03)00071-0;
RA Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D.,
RA Zuker C.S., Ryba N.J.;
RT "Coding of sweet, bitter, and umami tastes: different receptor cells
RT sharing similar signaling pathways.";
RL Cell 112:293-301(2003).
CC -!- FUNCTION: Receptor that may play a role in the perception of bitterness
CC and is gustducin-linked. May play a role in sensing the chemical
CC composition of the gastrointestinal content. The activity of this
CC receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation
CC and lead to the gating of TRPM5.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed in subsets of taste receptor cells of the
CC tongue and palate epithelium and exclusively in gustducin-positive
CC cells.
CC -!- MISCELLANEOUS: Most taste cells may be activated by a limited number of
CC bitter compounds; individual taste cells can discriminate among bitter
CC stimuli.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF227129; AAF43902.1; -; Genomic_DNA.
DR EMBL; AY724812; AAU21051.1; -; Genomic_DNA.
DR EMBL; BC101729; AAI01730.1; -; mRNA.
DR EMBL; BC101731; AAI01732.1; -; mRNA.
DR CCDS; CCDS3876.1; -.
DR RefSeq; NP_062545.1; NM_019599.2.
DR AlphaFoldDB; Q9NYW7; -.
DR SMR; Q9NYW7; -.
DR STRING; 9606.ENSP00000371932; -.
DR BindingDB; Q9NYW7; -.
DR ChEMBL; CHEMBL4523475; -.
DR GlyGen; Q9NYW7; 1 site.
DR iPTMnet; Q9NYW7; -.
DR PhosphoSitePlus; Q9NYW7; -.
DR BioMuta; TAS2R1; -.
DR DMDM; 29839667; -.
DR PaxDb; Q9NYW7; -.
DR PeptideAtlas; Q9NYW7; -.
DR PRIDE; Q9NYW7; -.
DR Antibodypedia; 22446; 124 antibodies from 23 providers.
DR DNASU; 50834; -.
DR Ensembl; ENST00000382492.4; ENSP00000371932.2; ENSG00000169777.7.
DR GeneID; 50834; -.
DR KEGG; hsa:50834; -.
DR MANE-Select; ENST00000382492.4; ENSP00000371932.2; NM_019599.3; NP_062545.1.
DR UCSC; uc003jem.2; human.
DR CTD; 50834; -.
DR DisGeNET; 50834; -.
DR GeneCards; TAS2R1; -.
DR HGNC; HGNC:14909; TAS2R1.
DR HPA; ENSG00000169777; Tissue enriched (testis).
DR MIM; 604796; gene.
DR neXtProt; NX_Q9NYW7; -.
DR OpenTargets; ENSG00000169777; -.
DR PharmGKB; PA37921; -.
DR VEuPathDB; HostDB:ENSG00000169777; -.
DR eggNOG; ENOG502S2SI; Eukaryota.
DR GeneTree; ENSGT00960000186638; -.
DR HOGENOM; CLU_072337_1_1_1; -.
DR InParanoid; Q9NYW7; -.
DR OMA; KHRKMAP; -.
DR OrthoDB; 1010573at2759; -.
DR PhylomeDB; Q9NYW7; -.
DR TreeFam; TF335891; -.
DR PathwayCommons; Q9NYW7; -.
DR Reactome; R-HSA-418594; G alpha (i) signalling events.
DR Reactome; R-HSA-420499; Class C/3 (Metabotropic glutamate/pheromone receptors).
DR Reactome; R-HSA-9717207; Sensory perception of sweet, bitter, and umami (glutamate) taste.
DR BioGRID-ORCS; 50834; 9 hits in 1058 CRISPR screens.
DR GeneWiki; TAS2R1; -.
DR GenomeRNAi; 50834; -.
DR Pharos; Q9NYW7; Tchem.
DR PRO; PR:Q9NYW7; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q9NYW7; protein.
DR Bgee; ENSG00000169777; Expressed in right testis and 39 other tissues.
DR ExpressionAtlas; Q9NYW7; baseline and differential.
DR Genevisible; Q9NYW7; HS.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0033038; F:bitter taste receptor activity; IDA:UniProtKB.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0008527; F:taste receptor activity; TAS:UniProtKB.
DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IDA:UniProtKB.
DR InterPro; IPR007960; TAS2R.
DR Pfam; PF05296; TAS2R; 1.
PE 1: Evidence at protein level;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..299
FT /note="Taste receptor type 2 member 1"
FT /id="PRO_0000082188"
FT TOPO_DOM 1..9
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 10..30
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 31..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 77..81
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..102
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 103..124
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 125..145
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 146..178
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 179..199
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 200..222
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 223..243
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 244..257
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 258..278
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 279..299
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 163
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 111
FT /note="R -> H (in dbSNP:rs41469)"
FT /id="VAR_020198"
FT VARIANT 141
FT /note="C -> Y (in dbSNP:rs2234232)"
FT /id="VAR_053340"
FT VARIANT 206
FT /note="R -> W (in dbSNP:rs2234233)"
FT /id="VAR_020199"
SQ SEQUENCE 299 AA; 34333 MW; CFB17DD15645392C CRC64;
MLESHLIIYF LLAVIQFLLG IFTNGIIVVV NGIDLIKHRK MAPLDLLLSC LAVSRIFLQL
FIFYVNVIVI FFIEFIMCSA NCAILLFINE LELWLATWLG VFYCAKVASV RHPLFIWLKM
RISKLVPWMI LGSLLYVSMI CVFHSKYAGF MVPYFLRKFF SQNATIQKED TLAIQIFSFV
AEFSVPLLIF LFAVLLLIFS LGRHTRQMRN TVAGSRVPGR GAPISALLSI LSFLILYFSH
CMIKVFLSSL KFHIRRFIFL FFILVIGIYP SGHSLILILG NPKLKQNAKK FLLHSKCCQ
