TA2R3_MOUSE
ID TA2R3_MOUSE Reviewed; 316 AA.
AC Q7TQA7; Q7M727;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 16-JAN-2004, sequence version 2.
DT 25-MAY-2022, entry version 108.
DE RecName: Full=Taste receptor type 2 member 3;
DE Short=T2R3;
DE AltName: Full=T2R137;
DE Short=T2R37;
DE AltName: Full=mT2r41;
GN Name=Tas2r3; Synonyms=T2r41, Tas2r137, Tas2r37;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000312|EMBL:AAP40338.1};
RN [1] {ECO:0000312|EMBL:AAP40338.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:AAP40338.1};
RX PubMed=12734386; DOI=10.1152/physiolgenomics.00060.2003;
RA Conte C., Ebeling M., Marcuz A., Nef P., Andres-Barquin P.J.;
RT "Evolutionary relationships of the Tas2r receptor gene families in mouse
RT and human.";
RL Physiol. Genomics 14:73-82(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3] {ECO:0000305}
RP IDENTIFICATION.
RX PubMed=12679530; DOI=10.1093/molbev/msg083;
RA Shi P., Zhang J., Yang H., Zhang Y.-P.;
RT "Adaptive diversification of bitter taste receptor genes in mammalian
RT evolution.";
RL Mol. Biol. Evol. 20:805-814(2003).
CC -!- FUNCTION: Gustducin-coupled receptor implicated in the perception of
CC bitter compounds in the oral cavity and the gastrointestinal tract.
CC Signals through PLCB2 and the calcium-regulated cation channel TRPM5
CC (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- MISCELLANEOUS: Several bitter taste receptors are expressed in a single
CC taste receptor cell.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAP40338.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AF532788; AAP40338.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC155653; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK001070; DAA01209.1; -; Genomic_DNA.
DR RefSeq; NP_001020556.1; NM_001025385.1.
DR AlphaFoldDB; Q7TQA7; -.
DR SMR; Q7TQA7; -.
DR STRING; 10090.ENSMUSP00000063743; -.
DR GlyGen; Q7TQA7; 1 site.
DR PhosphoSitePlus; Q7TQA7; -.
DR PaxDb; Q7TQA7; -.
DR PRIDE; Q7TQA7; -.
DR GeneID; 574417; -.
DR KEGG; mmu:574417; -.
DR UCSC; uc009bmv.1; mouse.
DR CTD; 574417; -.
DR MGI; MGI:3606604; Tas2r137.
DR eggNOG; ENOG502SKRK; Eukaryota.
DR InParanoid; Q7TQA7; -.
DR OrthoDB; 1010573at2759; -.
DR PhylomeDB; Q7TQA7; -.
DR TreeFam; TF335891; -.
DR Reactome; R-MMU-418594; G alpha (i) signalling events.
DR Reactome; R-MMU-420499; Class C/3 (Metabotropic glutamate/pheromone receptors).
DR Reactome; R-MMU-9717207; Sensory perception of sweet, bitter, and umami (glutamate) taste.
DR BioGRID-ORCS; 574417; 3 hits in 72 CRISPR screens.
DR PRO; PR:Q7TQA7; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q7TQA7; protein.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0033038; F:bitter taste receptor activity; ISO:MGI.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0008527; F:taste receptor activity; NAS:UniProtKB.
DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; ISO:MGI.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR007960; TAS2R.
DR Pfam; PF05296; TAS2R; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..316
FT /note="Taste receptor type 2 member 3"
FT /id="PRO_0000082202"
FT TOPO_DOM 1..7
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 8..28
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 29..50
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 51..71
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 72..86
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 108..128
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 150..186
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 187..207
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 208..234
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 235..255
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 256..266
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 267..287
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 288..316
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 166
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 316 AA; 36289 MW; 15C7C9B4F8BDEAB1 CRC64;
MFGFIEGVFL VLTITEFILG NLVNGFIVSI NSSYWFKSKK ISLSNFIITS LALFRIFLLW
IIFIDSLIIV FSYQTHDSGI MMQLIDVFWT FTNHFSIWLI SCLSVFYCLK IASFSHPSFL
WLKWRASRVV VGMLWGALLL SCVSTMSLMN EFKIYSALTR SKDTPNMTEY IRLKRQEYNL
MHVLGNLWKI PSLIVSLVAY LLLLLSLGKH TQQMQQYSID SRDQSAEAHK RAMRIISSFL
LFFLFYFLSF MILSSSRFLP ETRIARIIGV VISMSYLVGD SFILIVCNNK LKHTFVAMLP
CECGHLKPGS KGPSAS
