ID   TA2R3_PANPA             Reviewed;         315 AA.
AC   Q646D2; Q5Y513;
DT   23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Taste receptor type 2 member 3;
DE            Short=T2R3;
GN   Name=TAS2R3;
OS   Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9597;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=15496549; DOI=10.1093/molbev/msi027;
RA   Fischer A., Gilad Y., Man O., Paeaebo S.;
RT   "Evolution of bitter taste receptors in humans and apes.";
RL   Mol. Biol. Evol. 22:432-436(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=15466715; DOI=10.1073/pnas.0404894101;
RA   Parry C.M., Erkner A., le Coutre J.;
RT   "Divergence of T2R chemosensory receptor families in humans, bonobos, and
RT   chimpanzees.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:14830-14834(2004).
CC   -!- FUNCTION: Gustducin-coupled receptor implicated in the perception of
CC       bitter compounds in the oral cavity and the gastrointestinal tract.
CC       Signals through PLCB2 and the calcium-regulated cation channel TRPM5
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- MISCELLANEOUS: Several bitter taste receptors are expressed in a single
CC       taste receptor cell.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAV28562.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AY724861; AAU21087.1; -; Genomic_DNA.
DR   EMBL; AY677133; AAV28562.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; XP_003813428.1; XM_003813380.2.
DR   AlphaFoldDB; Q646D2; -.
DR   SMR; Q646D2; -.
DR   STRING; 9597.XP_003813428.1; -.
DR   GeneID; 100995845; -.
DR   CTD; 50831; -.
DR   eggNOG; ENOG502SKRK; Eukaryota.
DR   OMA; IDIFWTF; -.
DR   OrthoDB; 1010573at2759; -.
DR   Proteomes; UP000240080; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0050909; P:sensory perception of taste; IEA:UniProtKB-KW.
DR   InterPro; IPR007960; TAS2R.
DR   Pfam; PF05296; TAS2R; 1.
PE   3: Inferred from homology;
KW   G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW   Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..315
FT                   /note="Taste receptor type 2 member 3"
FT                   /id="PRO_0000082198"
FT   TOPO_DOM        1..5
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        6..26
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        27..41
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        42..62
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        63..93
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        94..114
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        115..127
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        128..148
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        149..185
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        186..206
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        207..233
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        234..254
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        255..265
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        266..286
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        287..315
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        165
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   315 AA;  35784 MW;  EB829A24AB43AE5B CRC64;
     MGLTEGVFLI LSGTQFTLGI LVNCFIELVN GSSWFKTKRM SLSDFIITTL ALLRIILLCI
     ILTDSFLIEF SPNTHDSGII MQIIDVSWTF TNHLSIWLAT CLGVLYCLKI ASFSHPTFLW
     LKWRVSRVMV WMLLGALLLS CGSTASLINE FKLYSVFRGI EATRNVTEHF RKKRSEYYLI
     HVLGTLWYLP PLIVSLASYS LLIFSLGRHT RQMLQNGTSS RDPTTEAHKR AIRIILSFFF
     LFLLYFLAFL IASFGNFLPK TKMAKMIGEV MTMFYPAGHS FILILGNSKL KQTFVVMLRC
     ESGHLKPGSK GPIFS