位置:首页 > 蛋白库 > TA2R4_PANPA
TA2R4_PANPA
ID   TA2R4_PANPA             Reviewed;         299 AA.
AC   Q646D3; Q5Y512;
DT   23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   29-MAR-2005, sequence version 2.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Taste receptor type 2 member 4;
DE            Short=T2R4;
GN   Name=TAS2R4;
OS   Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9597;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=15496549; DOI=10.1093/molbev/msi027;
RA   Fischer A., Gilad Y., Man O., Paeaebo S.;
RT   "Evolution of bitter taste receptors in humans and apes.";
RL   Mol. Biol. Evol. 22:432-436(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=15466715; DOI=10.1073/pnas.0404894101;
RA   Parry C.M., Erkner A., le Coutre J.;
RT   "Divergence of T2R chemosensory receptor families in humans, bonobos, and
RT   chimpanzees.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:14830-14834(2004).
CC   -!- FUNCTION: Gustducin-coupled receptor implicated in the perception of
CC       bitter compounds in the oral cavity and the gastrointestinal tract.
CC       Signals through PLCB2 and the calcium-regulated cation channel TRPM5
CC       (By similarity). In airway epithelial cells, binding of denatonium
CC       increases the intracellular calcium ion concentration and stimulates
CC       ciliary beat frequency (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Cell
CC       projection, cilium membrane. Note=In airway epithelial cells, localizes
CC       to motile cilia. {ECO:0000250}.
CC   -!- MISCELLANEOUS: Several bitter taste receptors are expressed in a single
CC       taste receptor cell.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY724860; AAU21086.1; -; Genomic_DNA.
DR   EMBL; AY677134; AAV28563.1; -; Genomic_DNA.
DR   RefSeq; XP_003813427.1; XM_003813379.2.
DR   AlphaFoldDB; Q646D3; -.
DR   SMR; Q646D3; -.
DR   STRING; 9597.XP_003813427.1; -.
DR   Ensembl; ENSPPAT00000007639; ENSPPAP00000001559; ENSPPAG00000007093.
DR   GeneID; 100995497; -.
DR   KEGG; pps:100995497; -.
DR   CTD; 50832; -.
DR   eggNOG; ENOG502S2SI; Eukaryota.
DR   GeneTree; ENSGT00960000186638; -.
DR   OMA; GAMKLMI; -.
DR   OrthoDB; 1010573at2759; -.
DR   Proteomes; UP000240080; Chromosome 7.
DR   Bgee; ENSPPAG00000007093; Expressed in cerebellum and 3 other tissues.
DR   GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0033038; F:bitter taste receptor activity; IEA:Ensembl.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007585; P:respiratory gaseous exchange by respiratory system; IEA:Ensembl.
DR   InterPro; IPR007960; TAS2R.
DR   InterPro; IPR030055; TAS2R4.
DR   PANTHER; PTHR11394:SF55; PTHR11394:SF55; 1.
DR   Pfam; PF05296; TAS2R; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Cell projection; Cilium; G-protein coupled receptor;
KW   Glycoprotein; Membrane; Receptor; Reference proteome; Sensory transduction;
KW   Taste; Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..299
FT                   /note="Taste receptor type 2 member 4"
FT                   /id="PRO_0000082206"
FT   TOPO_DOM        1..9
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        10..30
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        31..46
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        47..67
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        68..81
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..102
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        103..131
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        132..152
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        153..172
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        173..193
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        194..230
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        231..251
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        252..262
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        263..283
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        284..299
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        164
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        165
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   299 AA;  33882 MW;  F8BC0026C62FB003 CRC64;
     MLRLFYFSAI IASVILNFVG IIMNLFITVV NCKTWVKSHR ISSSDRILFS LGITRFLMLG
     LFLVNTIYFV SSNTERSVYL SAFFVLCFMF LDSSSLWFVT LLNILYCVKI TNFQHSVFLL
     LKRNISPKIP RLLLACVLIS AFTTCLYITL SQASPFPELV TTRNNTSFNI NEGILSLVVS
     LVLSSSLQFI INVTSASLLI HSLRRHIQKM QKNATGFWNP QTEAHVGAMK LMVYFLILYI
     PYSVATLVQY LPFYAGMDMG TKSICLIFAT LYSPGHSVLI IITHPKLKTT AKKILCFKK
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024