ID   TA2R4_PANTR             Reviewed;         299 AA.
AC   Q646B0;
DT   23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   02-DEC-2020, entry version 73.
DE   RecName: Full=Taste receptor type 2 member 4;
DE            Short=T2R4;
GN   Name=TAS2R4;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=15496549; DOI=10.1093/molbev/msi027;
RA   Fischer A., Gilad Y., Man O., Paeaebo S.;
RT   "Evolution of bitter taste receptors in humans and apes.";
RL   Mol. Biol. Evol. 22:432-436(2005).
CC   -!- FUNCTION: Gustducin-coupled receptor implicated in the perception of
CC       bitter compounds in the oral cavity and the gastrointestinal tract.
CC       Signals through PLCB2 and the calcium-regulated cation channel TRPM5
CC       (By similarity). In airway epithelial cells, binding of denatonium
CC       increases the intracellular calcium ion concentration and stimulates
CC       ciliary beat frequency (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Cell
CC       projection, cilium membrane. Note=In airway epithelial cells, localizes
CC       to motile cilia. {ECO:0000250}.
CC   -!- MISCELLANEOUS: Several bitter taste receptors are expressed in a single
CC       taste receptor cell.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC       {ECO:0000305}.
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DR   EMBL; AY724893; AAU21109.1; -; Genomic_DNA.
DR   RefSeq; NP_001009161.1; NM_001009161.1.
DR   STRING; 9598.ENSPTRP00000054263; -.
DR   PaxDb; Q646B0; -.
DR   GeneID; 494114; -.
DR   KEGG; ptr:494114; -.
DR   CTD; 50832; -.
DR   eggNOG; ENOG502S2SI; Eukaryota.
DR   InParanoid; Q646B0; -.
DR   OrthoDB; 1010573at2759; -.
DR   Proteomes; UP000002277; Unplaced.
DR   GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0033038; F:bitter taste receptor activity; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IBA:GO_Central.
DR   InterPro; IPR007960; TAS2R.
DR   InterPro; IPR030055; TAS2R4.
DR   PANTHER; PTHR11394:SF55; PTHR11394:SF55; 1.
DR   Pfam; PF05296; TAS2R; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Cell projection; Cilium; G-protein coupled receptor;
KW   Glycoprotein; Membrane; Receptor; Reference proteome; Sensory transduction;
KW   Taste; Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..299
FT                   /note="Taste receptor type 2 member 4"
FT                   /id="PRO_0000082207"
FT   TOPO_DOM        1..9
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        10..30
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        31..46
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        47..67
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        68..81
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..102
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        103..131
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        132..152
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        153..172
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        173..193
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        194..230
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        231..251
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        252..262
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        263..283
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        284..299
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        164
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        165
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   299 AA;  33892 MW;  F5CB0CA9F1270088 CRC64;
     MLRLFYFSAI IASVILNFVG IIMNLFITVV NCKTWVKSHR ISSSDRILFS LGITRFLMLG
     LFLVNTIYFV SSNXERSVYL SAFFVLCFMF LDSSSLWFVT LLNILYCVKI TNFQHSVFLL
     LKRNISPKIP RLLLACVLIS AFTTCLYITL SQASPFPELV TTRNNTSFNI NEGILSLVVS
     LVLSSSLQFI INVTSASLLI HSLRRHIQKM QKNATGFWNP QTEAHVGAMK LMVYFLILYI
     PYSVATLVQY LPFYAGMDMG TKSICLIFAT LYSPGHSVLI IITHPKLKTT AKKILCFKK