ID   TA2R7_HUMAN             Reviewed;         318 AA.
AC   Q9NYW3; Q645Y1;
DT   11-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 156.
DE   RecName: Full=Taste receptor type 2 member 7;
DE            Short=T2R7;
DE   AltName: Full=Taste receptor family B member 4;
DE            Short=TRB4;
GN   Name=TAS2R7;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TOPOLOGY.
RX   PubMed=10761934; DOI=10.1016/s0092-8674(00)80705-9;
RA   Adler E., Hoon M.A., Mueller K.L., Chandrashekar J., Ryba N.J.P.,
RA   Zuker C.S.;
RT   "A novel family of mammalian taste receptors.";
RL   Cell 100:693-702(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=15496549; DOI=10.1093/molbev/msi027;
RA   Fischer A., Gilad Y., Man O., Paeaebo S.;
RT   "Evolution of bitter taste receptors in humans and apes.";
RL   Mol. Biol. Evol. 22:432-436(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   CHARACTERIZATION.
RX   PubMed=10761935; DOI=10.1016/s0092-8674(00)80706-0;
RA   Chandrashekar J., Mueller K.L., Hoon M.A., Adler E., Feng L., Guo W.,
RA   Zuker C.S., Ryba N.J.P.;
RT   "T2Rs function as bitter taste receptors.";
RL   Cell 100:703-711(2000).
RN   [5]
RP   REVIEW.
RX   PubMed=12139982; DOI=10.1016/s0959-4388(02)00345-8;
RA   Montmayeur J.-P., Matsunami H.;
RT   "Receptors for bitter and sweet taste.";
RL   Curr. Opin. Neurobiol. 12:366-371(2002).
RN   [6]
RP   REVIEW.
RX   PubMed=11696554; DOI=10.1074/jbc.r100054200;
RA   Margolskee R.F.;
RT   "Molecular mechanisms of bitter and sweet taste transduction.";
RL   J. Biol. Chem. 277:1-4(2002).
RN   [7]
RP   REVIEW.
RX   PubMed=12581520; DOI=10.1016/s0092-8674(03)00071-0;
RA   Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D.,
RA   Zuker C.S., Ryba N.J.;
RT   "Coding of sweet, bitter, and umami tastes: different receptor cells
RT   sharing similar signaling pathways.";
RL   Cell 112:293-301(2003).
CC   -!- FUNCTION: Gustducin-coupled receptor implicated in the perception of
CC       bitter compounds in the oral cavity and the gastrointestinal tract.
CC       Signals through PLCB2 and the calcium-regulated cation channel TRPM5.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Expressed in subsets of taste receptor cells of the
CC       tongue and palate epithelium and exclusively in gustducin-positive
CC       cells.
CC   -!- MISCELLANEOUS: Several bitter taste receptors are expressed in a single
CC       taste receptor cell.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC       {ECO:0000305}.
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DR   EMBL; AF227133; AAF43906.1; -; Genomic_DNA.
DR   EMBL; AY724936; AAU21138.1; -; Genomic_DNA.
DR   EMBL; BC069091; AAH69091.1; -; mRNA.
DR   EMBL; BC093992; AAH93992.1; -; mRNA.
DR   EMBL; BC113561; AAI13562.1; -; mRNA.
DR   CCDS; CCDS8631.1; -.
DR   RefSeq; NP_076408.1; NM_023919.2.
DR   AlphaFoldDB; Q9NYW3; -.
DR   SMR; Q9NYW3; -.
DR   BioGRID; 119147; 14.
DR   IntAct; Q9NYW3; 11.
DR   STRING; 9606.ENSP00000240687; -.
DR   ChEMBL; CHEMBL4523472; -.
DR   GlyGen; Q9NYW3; 2 sites.
DR   iPTMnet; Q9NYW3; -.
DR   PhosphoSitePlus; Q9NYW3; -.
DR   BioMuta; TAS2R7; -.
DR   PaxDb; Q9NYW3; -.
DR   PeptideAtlas; Q9NYW3; -.
DR   PRIDE; Q9NYW3; -.
DR   TopDownProteomics; Q9NYW3; -.
DR   Antibodypedia; 23392; 136 antibodies from 22 providers.
DR   DNASU; 50837; -.
DR   Ensembl; ENST00000240687.2; ENSP00000240687.2; ENSG00000121377.2.
DR   Ensembl; ENST00000574656.1; ENSP00000458498.1; ENSG00000273326.1.
DR   Ensembl; ENST00000613239.1; ENSP00000484743.1; ENSG00000274327.1.
DR   GeneID; 50837; -.
DR   KEGG; hsa:50837; -.
DR   MANE-Select; ENST00000240687.2; ENSP00000240687.2; NM_023919.2; NP_076408.1.
DR   UCSC; uc001qyv.3; human.
DR   CTD; 50837; -.
DR   GeneCards; TAS2R7; -.
DR   HGNC; HGNC:14913; TAS2R7.
DR   HPA; ENSG00000121377; Not detected.
DR   MIM; 604793; gene.
DR   neXtProt; NX_Q9NYW3; -.
DR   OpenTargets; ENSG00000121377; -.
DR   PharmGKB; PA37925; -.
DR   VEuPathDB; HostDB:ENSG00000121377; -.
DR   eggNOG; ENOG502SKRK; Eukaryota.
DR   GeneTree; ENSGT00960000186648; -.
DR   HOGENOM; CLU_072337_3_0_1; -.
DR   InParanoid; Q9NYW3; -.
DR   OMA; WRIDRVI; -.
DR   OrthoDB; 1010573at2759; -.
DR   PhylomeDB; Q9NYW3; -.
DR   TreeFam; TF335891; -.
DR   PathwayCommons; Q9NYW3; -.
DR   Reactome; R-HSA-418594; G alpha (i) signalling events.
DR   Reactome; R-HSA-420499; Class C/3 (Metabotropic glutamate/pheromone receptors).
DR   Reactome; R-HSA-9717207; Sensory perception of sweet, bitter, and umami (glutamate) taste.
DR   SignaLink; Q9NYW3; -.
DR   BioGRID-ORCS; 50837; 8 hits in 1058 CRISPR screens.
DR   GeneWiki; TAS2R7; -.
DR   GenomeRNAi; 50837; -.
DR   Pharos; Q9NYW3; Tchem.
DR   PRO; PR:Q9NYW3; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   RNAct; Q9NYW3; protein.
DR   Bgee; ENSG00000121377; Expressed in calcaneal tendon.
DR   Genevisible; Q9NYW3; HS.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0033038; F:bitter taste receptor activity; IDA:UniProtKB.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0008527; F:taste receptor activity; TAS:UniProtKB.
DR   GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IDA:UniProtKB.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR007960; TAS2R.
DR   InterPro; IPR030053; TAS2R7.
DR   PANTHER; PTHR11394:SF58; PTHR11394:SF58; 1.
DR   Pfam; PF05296; TAS2R; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   1: Evidence at protein level;
KW   G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW   Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..318
FT                   /note="Taste receptor type 2 member 7"
FT                   /id="PRO_0000082220"
FT   TOPO_DOM        1..9
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        10..30
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        31..55
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        56..76
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        77..94
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        95..115
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        116..128
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        129..149
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        150..187
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        188..208
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        209..235
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        236..256
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        257..266
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        267..287
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        288..318
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        167
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        175
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VARIANT         263
FT                   /note="T -> M (in dbSNP:rs11838055)"
FT                   /id="VAR_062084"
FT   VARIANT         263
FT                   /note="T -> S (in dbSNP:rs3759251)"
FT                   /id="VAR_021852"
FT   VARIANT         304
FT                   /note="M -> I (in dbSNP:rs619381)"
FT                   /id="VAR_024185"
SQ   SEQUENCE   318 AA;  36550 MW;  F187ADB2D8274B8A CRC64;
     MADKVQTTLL FLAVGEFSVG ILGNAFIGLV NCMDWVKKRK IASIDLILTS LAISRICLLC
     VILLDCFILV LYPDVYATGK EMRIIDFFWT LTNHLSIWFA TCLSIYYFFK IGNFFHPLFL
     WMKWRIDRVI SWILLGCVVL SVFISLPATE NLNADFRFCV KAKRKTNLTW SCRVNKTQHA
     STKLFLNLAT LLPFCVCLMS FFLLILSLRR HIRRMQLSAT GCRDPSTEAH VRALKAVISF
     LLLFIAYYLS FLIATSSYFM PETELAVIFG ESIALIYPSS HSFILILGNN KLRHASLKVI
     WKVMSILKGR KFQQHKQI