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TA2R7_MOUSE
ID   TA2R7_MOUSE             Reviewed;         312 AA.
AC   P59530; Q0VE81; Q7M726;
DT   11-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT   11-APR-2003, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Taste receptor type 2 member 7;
DE            Short=T2R7;
DE   AltName: Full=STC7-4;
DE   AltName: Full=T2R30;
DE   AltName: Full=T2R6;
DE   AltName: Full=mT2R42;
GN   Name=Tas2r7; Synonyms=Tas2r130, Tas2r6;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=12920489; DOI=10.1007/s00251-003-0591-8;
RA   Scalzo A.A., Wheat R., Dubbelde C., Stone L., Clark P., Du Y., Dong N.,
RA   Stoll J., Yokoyama W.M., Brown M.G.;
RT   "Molecular genetic characterization of the distal NKC recombination hotspot
RT   and putative murine CMV resistance control locus.";
RL   Immunogenetics 55:370-378(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Zuker C.S., Adler J.E., Ryba N., Mueller K., Hoon M.;
RT   "T2r taste receptor family.";
RL   Patent number WO0118050, 15-MAR-2001.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 56-280.
RX   PubMed=11854532; DOI=10.1073/pnas.042617699;
RA   Wu S.V., Rozengurt N., Yang M., Young S.H., Sinnett-Smith J., Rozengurt E.;
RT   "Expression of bitter taste receptors of the T2R family in the
RT   gastrointestinal tract and enteroendocrine STC-1 cells.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:2392-2397(2002).
RN   [6]
RP   IDENTIFICATION.
RX   PubMed=12679530; DOI=10.1093/molbev/msg083;
RA   Shi P., Zhang J., Yang H., Zhang Y.-P.;
RT   "Adaptive diversification of bitter taste receptor genes in mammalian
RT   evolution.";
RL   Mol. Biol. Evol. 20:805-814(2003).
RN   [7]
RP   REVIEW.
RX   PubMed=12139982; DOI=10.1016/s0959-4388(02)00345-8;
RA   Montmayeur J.-P., Matsunami H.;
RT   "Receptors for bitter and sweet taste.";
RL   Curr. Opin. Neurobiol. 12:366-371(2002).
RN   [8]
RP   REVIEW.
RX   PubMed=11696554; DOI=10.1074/jbc.r100054200;
RA   Margolskee R.F.;
RT   "Molecular mechanisms of bitter and sweet taste transduction.";
RL   J. Biol. Chem. 277:1-4(2002).
RN   [9]
RP   REVIEW.
RX   PubMed=12581520; DOI=10.1016/s0092-8674(03)00071-0;
RA   Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D.,
RA   Zuker C.S., Ryba N.J.;
RT   "Coding of sweet, bitter, and umami tastes: different receptor cells
RT   sharing similar signaling pathways.";
RL   Cell 112:293-301(2003).
CC   -!- FUNCTION: Gustducin-coupled receptor implicated in the perception of
CC       bitter compounds in the oral cavity and the gastrointestinal tract.
CC       Signals through PLCB2 and the calcium-regulated cation channel TRPM5.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Expressed in subsets of taste receptor cells of the
CC       tongue and palate epithelium and exclusively in gustducin-positive
CC       cells. Expressed in 15% taste bud cells in circumvallate and foliate
CC       papillae but only in 2% in fungiform papillae. Expressed in gastric and
CC       duodenal tissues.
CC   -!- MISCELLANEOUS: Several bitter taste receptors are expressed in a single
CC       taste receptor cell.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC       {ECO:0000305}.
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DR   EMBL; AF462604; AAO14564.1; -; Genomic_DNA.
DR   EMBL; AX097857; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC140204; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC119329; AAI19330.1; -; mRNA.
DR   EMBL; AF412303; AAL85200.1; -; mRNA.
DR   EMBL; BK001071; DAA01210.1; -; Genomic_DNA.
DR   CCDS; CCDS20608.1; -.
DR   RefSeq; NP_954607.1; NM_199156.1.
DR   AlphaFoldDB; P59530; -.
DR   SMR; P59530; -.
DR   STRING; 10090.ENSMUSP00000063954; -.
DR   GlyGen; P59530; 2 sites.
DR   PhosphoSitePlus; P59530; -.
DR   PaxDb; P59530; -.
DR   PRIDE; P59530; -.
DR   Antibodypedia; 23392; 136 antibodies from 22 providers.
DR   DNASU; 387355; -.
DR   Ensembl; ENSMUST00000067597; ENSMUSP00000063954; ENSMUSG00000054497.
DR   GeneID; 387355; -.
DR   KEGG; mmu:387355; -.
DR   UCSC; uc009eiv.1; mouse.
DR   CTD; 387355; -.
DR   MGI; MGI:2681278; Tas2r130.
DR   VEuPathDB; HostDB:ENSMUSG00000054497; -.
DR   eggNOG; ENOG502SKRK; Eukaryota.
DR   GeneTree; ENSGT00960000186648; -.
DR   HOGENOM; CLU_072337_3_0_1; -.
DR   InParanoid; P59530; -.
DR   OMA; WRIDRVI; -.
DR   OrthoDB; 1010573at2759; -.
DR   PhylomeDB; P59530; -.
DR   TreeFam; TF335891; -.
DR   Reactome; R-MMU-418594; G alpha (i) signalling events.
DR   Reactome; R-MMU-420499; Class C/3 (Metabotropic glutamate/pheromone receptors).
DR   Reactome; R-MMU-9717207; Sensory perception of sweet, bitter, and umami (glutamate) taste.
DR   BioGRID-ORCS; 387355; 3 hits in 71 CRISPR screens.
DR   PRO; PR:P59530; -.
DR   Proteomes; UP000000589; Chromosome 6.
DR   RNAct; P59530; protein.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0033038; F:bitter taste receptor activity; ISO:MGI.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; ISO:MGI.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR007960; TAS2R.
DR   InterPro; IPR030053; TAS2R7.
DR   PANTHER; PTHR11394:SF58; PTHR11394:SF58; 1.
DR   Pfam; PF05296; TAS2R; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW   Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..312
FT                   /note="Taste receptor type 2 member 7"
FT                   /id="PRO_0000082217"
FT   TOPO_DOM        1..9
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        10..30
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        31..49
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        50..70
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        71..101
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..122
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        123..128
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        129..149
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        150..187
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        188..208
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        209..235
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        236..256
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        257..266
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        267..287
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        288..312
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        151
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        167
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        66
FT                   /note="C -> G (in Ref. 5; AAL85200)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        84..85
FT                   /note="TV -> II (in Ref. 5; AAL85200)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        107..108
FT                   /note="YL -> HF (in Ref. 5; AAL85200)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        138..140
FT                   /note="VII -> LIL (in Ref. 5; AAL85200)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        153
FT                   /note="S -> T (in Ref. 5; AAL85200)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        174
FT                   /note="V -> L (in Ref. 5; AAL85200)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        179
FT                   /note="H -> Y (in Ref. 5; AAL85200)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        215
FT                   /note="I -> M (in Ref. 5; AAL85200)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        218
FT                   /note="S -> N (in Ref. 5; AAL85200)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        223
FT                   /note="K -> N (in Ref. 5; AAL85200)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        234
FT                   /note="M -> T (in Ref. 5; AAL85200)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        242
FT                   /note="A -> V (in Ref. 5; AAL85200)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        245
FT                   /note="V -> I (in Ref. 5; AAL85200)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   312 AA;  35510 MW;  73EBE2CA794AAF22 CRC64;
     MTYETDTTLM LVAVGEALVG ILGNAFIALV NFMGWMKNRK IASIDLILSS VAMSRICLQC
     IILLDCIILV QYPDTYNRGK EMRTVDFFWT LTNHLSVWFA TCLSIFYLFK IANFFHPLFL
     WIKWRIDKLI LRTLLACVII SLCFSLPVTE NLSDDFRRCV KTKERINSTL RCKVNKAGHA
     SVKVNLNLVM LFPFSVSLVS FLLLILSLWR HTRQIQLSVT GYKDPSTTAH VKAMKAVISF
     LALFVVYCLA FLIATSSYFM PESELAVIWG ELIALIYPSS HSFILILGSS KLKQASVRVL
     CRVKTMLKGK KY
 
 
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