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TA2R7_RAT
ID   TA2R7_RAT               Reviewed;         312 AA.
AC   Q9JKE9; Q67ET9;
DT   11-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 2.
DT   25-MAY-2022, entry version 117.
DE   RecName: Full=Taste receptor type 2 member 7;
DE            Short=T2R7;
DE   AltName: Full=Taste receptor type 2 member 6;
DE            Short=T2R6;
GN   Name=Tas2r7; Synonyms=Tas2r6;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Sprague-Dawley;
RA   Conte C., Ebeling M., Marcuz A., Andres-Barquin P.J.;
RT   "Identification of new putative rat taste receptors belonging to the T2R
RT   family.";
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 16-297, AND TOPOLOGY.
RX   PubMed=10761934; DOI=10.1016/s0092-8674(00)80705-9;
RA   Adler E., Hoon M.A., Mueller K.L., Chandrashekar J., Ryba N.J.P.,
RA   Zuker C.S.;
RT   "A novel family of mammalian taste receptors.";
RL   Cell 100:693-702(2000).
RN   [3]
RP   CHARACTERIZATION.
RX   PubMed=10761935; DOI=10.1016/s0092-8674(00)80706-0;
RA   Chandrashekar J., Mueller K.L., Hoon M.A., Adler E., Feng L., Guo W.,
RA   Zuker C.S., Ryba N.J.P.;
RT   "T2Rs function as bitter taste receptors.";
RL   Cell 100:703-711(2000).
RN   [4]
RP   TISSUE SPECIFICITY.
RX   PubMed=11854532; DOI=10.1073/pnas.042617699;
RA   Wu S.V., Rozengurt N., Yang M., Young S.H., Sinnett-Smith J., Rozengurt E.;
RT   "Expression of bitter taste receptors of the T2R family in the
RT   gastrointestinal tract and enteroendocrine STC-1 cells.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:2392-2397(2002).
RN   [5]
RP   REVIEW.
RX   PubMed=12139982; DOI=10.1016/s0959-4388(02)00345-8;
RA   Montmayeur J.-P., Matsunami H.;
RT   "Receptors for bitter and sweet taste.";
RL   Curr. Opin. Neurobiol. 12:366-371(2002).
RN   [6]
RP   REVIEW.
RX   PubMed=11696554; DOI=10.1074/jbc.r100054200;
RA   Margolskee R.F.;
RT   "Molecular mechanisms of bitter and sweet taste transduction.";
RL   J. Biol. Chem. 277:1-4(2002).
RN   [7]
RP   REVIEW.
RX   PubMed=12581520; DOI=10.1016/s0092-8674(03)00071-0;
RA   Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D.,
RA   Zuker C.S., Ryba N.J.;
RT   "Coding of sweet, bitter, and umami tastes: different receptor cells
RT   sharing similar signaling pathways.";
RL   Cell 112:293-301(2003).
CC   -!- FUNCTION: Gustducin-coupled receptor implicated in the perception of
CC       bitter compounds in the oral cavity and the gastrointestinal tract.
CC       Signals through PLCB2 and the calcium-regulated cation channel TRPM5.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Expressed in subsets of taste receptor cells of the
CC       tongue and palate epithelium and exclusively in gustducin-positive
CC       cells. Expressed in 15% taste bud cells in circumvallate and foliate
CC       papillae but only in 2% in fungiform papillae. Expressed in the
CC       duodenum, antrum and fundus (part of the stomach) and in gastric
CC       endocrine cells. {ECO:0000269|PubMed:11854532}.
CC   -!- MISCELLANEOUS: Several bitter taste receptors are expressed in a single
CC       taste receptor cell.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC       {ECO:0000305}.
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DR   EMBL; AY362731; AAR13340.1; -; Genomic_DNA.
DR   EMBL; AF240766; AAF45304.1; -; mRNA.
DR   RefSeq; XP_001074122.1; XM_001074122.3.
DR   RefSeq; XP_002726514.1; XM_002726468.3.
DR   AlphaFoldDB; Q9JKE9; -.
DR   SMR; Q9JKE9; -.
DR   STRING; 10116.ENSRNOP00000007435; -.
DR   GlyGen; Q9JKE9; 2 sites.
DR   PhosphoSitePlus; Q9JKE9; -.
DR   PaxDb; Q9JKE9; -.
DR   Ensembl; ENSRNOT00000007435; ENSRNOP00000007435; ENSRNOG00000005645.
DR   GeneID; 690334; -.
DR   UCSC; RGD:1597354; rat.
DR   CTD; 387355; -.
DR   RGD; 1597354; LOC690334.
DR   eggNOG; ENOG502SKRK; Eukaryota.
DR   GeneTree; ENSGT00960000186648; -.
DR   HOGENOM; CLU_072337_3_0_1; -.
DR   InParanoid; Q9JKE9; -.
DR   OMA; WRIDRVI; -.
DR   OrthoDB; 1010573at2759; -.
DR   PhylomeDB; Q9JKE9; -.
DR   TreeFam; TF335891; -.
DR   Reactome; R-RNO-418594; G alpha (i) signalling events.
DR   Reactome; R-RNO-420499; Class C/3 (Metabotropic glutamate/pheromone receptors).
DR   Reactome; R-RNO-9717207; Sensory perception of sweet, bitter, and umami (glutamate) taste.
DR   PRO; PR:Q9JKE9; -.
DR   Proteomes; UP000002494; Chromosome 4.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0033038; F:bitter taste receptor activity; ISO:RGD.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0008527; F:taste receptor activity; TAS:UniProtKB.
DR   GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; ISO:RGD.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR007960; TAS2R.
DR   InterPro; IPR030053; TAS2R7.
DR   PANTHER; PTHR11394:SF58; PTHR11394:SF58; 1.
DR   Pfam; PF05296; TAS2R; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   1: Evidence at protein level;
KW   G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW   Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..312
FT                   /note="Taste receptor type 2 member 7"
FT                   /id="PRO_0000082218"
FT   TOPO_DOM        1..9
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        10..30
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        31..49
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        50..70
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        71..101
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..122
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        123..128
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        129..149
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        150..187
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        188..208
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        209..235
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        236..256
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        257..266
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        267..287
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        288..312
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        151
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        167
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   312 AA;  35844 MW;  C3DBB08AE003A7E0 CRC64;
     MTYETDTTLM FVAVCEALVG ILGNAFIALV NFMGWMKNRK ITAIDLILSS LAMSRICLQC
     IILLDCIILV QYPDTYNRGK EMRIIDFFWT LTNHLSVWFA TCLSIFYFFK IANFFHPLFL
     WIKWRIDKLI LRTLLACLIL SLCFSLPVTE NLTDDFRRCV KTKERINSTL RCKLNKAGYA
     SVKVNLNLVM LFPFSVSLVS FLLLILSLWR HTRQMQLNVT GYNDPSTTAH VKATKAVISF
     LVLFIVYCLA FLIATSSYFM PESELAVIWG ELIALIYPSS HSFILILGNS KLKQASVRVL
     CRVKTMLKGR KY
 
 
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