TA2R9_HUMAN
ID TA2R9_HUMAN Reviewed; 312 AA.
AC Q9NYW1; Q502V7; Q50KT0; Q50KT1; Q645W9;
DT 11-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=Taste receptor type 2 member 9;
DE Short=T2R9;
DE AltName: Full=Taste receptor family B member 6;
DE Short=TRB6;
GN Name=TAS2R9;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TOPOLOGY.
RX PubMed=10761934; DOI=10.1016/s0092-8674(00)80705-9;
RA Adler E., Hoon M.A., Mueller K.L., Chandrashekar J., Ryba N.J.P.,
RA Zuker C.S.;
RT "A novel family of mammalian taste receptors.";
RL Cell 100:693-702(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=15496549; DOI=10.1093/molbev/msi027;
RA Fischer A., Gilad Y., Man O., Paeaebo S.;
RT "Evolution of bitter taste receptors in humans and apes.";
RL Mol. Biol. Evol. 22:432-436(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-187.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 9-298, AND VARIANT ALA-187.
RX PubMed=15744053; DOI=10.1534/genetics.104.037523;
RA Go Y., Satta Y., Takenaka O., Takahata N.;
RT "Lineage-specific loss of function of bitter taste receptor genes in humans
RT and nonhuman primates.";
RL Genetics 170:313-326(2005).
RN [5]
RP CHARACTERIZATION.
RX PubMed=10761935; DOI=10.1016/s0092-8674(00)80706-0;
RA Chandrashekar J., Mueller K.L., Hoon M.A., Adler E., Feng L., Guo W.,
RA Zuker C.S., Ryba N.J.P.;
RT "T2Rs function as bitter taste receptors.";
RL Cell 100:703-711(2000).
RN [6]
RP REVIEW.
RX PubMed=12139982; DOI=10.1016/s0959-4388(02)00345-8;
RA Montmayeur J.-P., Matsunami H.;
RT "Receptors for bitter and sweet taste.";
RL Curr. Opin. Neurobiol. 12:366-371(2002).
RN [7]
RP REVIEW.
RX PubMed=11696554; DOI=10.1074/jbc.r100054200;
RA Margolskee R.F.;
RT "Molecular mechanisms of bitter and sweet taste transduction.";
RL J. Biol. Chem. 277:1-4(2002).
RN [8]
RP REVIEW.
RX PubMed=12581520; DOI=10.1016/s0092-8674(03)00071-0;
RA Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D.,
RA Zuker C.S., Ryba N.J.;
RT "Coding of sweet, bitter, and umami tastes: different receptor cells
RT sharing similar signaling pathways.";
RL Cell 112:293-301(2003).
CC -!- FUNCTION: Gustducin-coupled receptor implicated in the perception of
CC bitter compounds in the oral cavity and the gastrointestinal tract.
CC Signals through PLCB2 and the calcium-regulated cation channel TRPM5
CC (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed in subsets of taste receptor cells of the
CC tongue and palate epithelium and exclusively in gustducin-positive
CC cells.
CC -!- MISCELLANEOUS: Several bitter taste receptors are expressed in a single
CC taste receptor cell.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF227135; AAF43908.1; -; Genomic_DNA.
DR EMBL; AY724954; AAU21150.1; -; Genomic_DNA.
DR EMBL; BC069066; AAH69066.1; -; mRNA.
DR EMBL; BC095519; AAH95519.1; -; mRNA.
DR EMBL; AB199063; BAD97966.1; -; Genomic_DNA.
DR EMBL; AB199064; BAD97967.1; -; Genomic_DNA.
DR EMBL; AB199065; BAD97968.1; -; Genomic_DNA.
DR CCDS; CCDS8633.1; -.
DR RefSeq; NP_076406.1; NM_023917.2.
DR AlphaFoldDB; Q9NYW1; -.
DR SMR; Q9NYW1; -.
DR STRING; 9606.ENSP00000240691; -.
DR BindingDB; Q9NYW1; -.
DR ChEMBL; CHEMBL3309110; -.
DR GlyGen; Q9NYW1; 1 site.
DR iPTMnet; Q9NYW1; -.
DR PhosphoSitePlus; Q9NYW1; -.
DR BioMuta; TAS2R9; -.
DR DMDM; 29839661; -.
DR MassIVE; Q9NYW1; -.
DR PaxDb; Q9NYW1; -.
DR PeptideAtlas; Q9NYW1; -.
DR PRIDE; Q9NYW1; -.
DR Antibodypedia; 23398; 105 antibodies from 20 providers.
DR DNASU; 50835; -.
DR Ensembl; ENST00000240691.4; ENSP00000240691.2; ENSG00000121381.4.
DR Ensembl; ENST00000573524.1; ENSP00000460247.1; ENSG00000273086.1.
DR Ensembl; ENST00000616297.2; ENSP00000480069.1; ENSG00000273713.2.
DR GeneID; 50835; -.
DR KEGG; hsa:50835; -.
DR MANE-Select; ENST00000240691.4; ENSP00000240691.2; NM_023917.2; NP_076406.1.
DR UCSC; uc001qyx.4; human.
DR CTD; 50835; -.
DR DisGeNET; 50835; -.
DR GeneCards; TAS2R9; -.
DR HGNC; HGNC:14917; TAS2R9.
DR HPA; ENSG00000121381; Not detected.
DR MIM; 604795; gene.
DR neXtProt; NX_Q9NYW1; -.
DR OpenTargets; ENSG00000121381; -.
DR PharmGKB; PA37927; -.
DR VEuPathDB; HostDB:ENSG00000121381; -.
DR eggNOG; ENOG502SY8P; Eukaryota.
DR GeneTree; ENSGT00960000186648; -.
DR HOGENOM; CLU_072337_3_0_1; -.
DR InParanoid; Q9NYW1; -.
DR OMA; TIGIWGN; -.
DR OrthoDB; 1010573at2759; -.
DR PhylomeDB; Q9NYW1; -.
DR TreeFam; TF335891; -.
DR PathwayCommons; Q9NYW1; -.
DR Reactome; R-HSA-418594; G alpha (i) signalling events.
DR Reactome; R-HSA-420499; Class C/3 (Metabotropic glutamate/pheromone receptors).
DR BioGRID-ORCS; 50835; 12 hits in 1062 CRISPR screens.
DR GeneWiki; TAS2R9; -.
DR GenomeRNAi; 50835; -.
DR Pharos; Q9NYW1; Tchem.
DR PRO; PR:Q9NYW1; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q9NYW1; protein.
DR Bgee; ENSG00000121381; Expressed in cortical plate and 3 other tissues.
DR Genevisible; Q9NYW1; HS.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0033038; F:bitter taste receptor activity; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0008527; F:taste receptor activity; TAS:UniProtKB.
DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IBA:GO_Central.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR007960; TAS2R.
DR Pfam; PF05296; TAS2R; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..312
FT /note="Taste receptor type 2 member 9"
FT /id="PRO_0000082232"
FT TOPO_DOM 1..9
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 10..32
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 33..52
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 53..72
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 73..86
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..109
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 110..128
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..146
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 147..180
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 181..203
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 204..234
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 235..257
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 258..261
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 262..284
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 285..312
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 164
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 170
FT /note="K -> Q (in dbSNP:rs11054043)"
FT /id="VAR_053345"
FT VARIANT 187
FT /note="V -> A (in dbSNP:rs3741845)"
FT /evidence="ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:15744053"
FT /id="VAR_020204"
FT VARIANT 238
FT /note="L -> V (in dbSNP:rs11054042)"
FT /id="VAR_053346"
SQ SEQUENCE 312 AA; 35611 MW; CCE66F1E31051F49 CRC64;
MPSAIEAIYI ILIAGELTIG IWGNGFIVLV NCIDWLKRRD ISLIDIILIS LAISRICLLC
VISLDGFFML LFPGTYGNSV LVSIVNVVWT FANNSSLWFT SCLSIFYLLK IANISHPFFF
WLKLKINKVM LAILLGSFLI SLIISVPKND DMWYHLFKVS HEENITWKFK VSKIPGTFKQ
LTLNLGVMVP FILCLISFFL LLFSLVRHTK QIRLHATGFR DPSTEAHMRA IKAVIIFLLL
LIVYYPVFLV MTSSALIPQG KLVLMIGDIV TVIFPSSHSF ILIMGNSKLR EAFLKMLRFV
KCFLRRRKPF VP
