TA2R_BOVIN
ID TA2R_BOVIN Reviewed; 343 AA.
AC Q95125; Q95124;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 2.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Thromboxane A2 receptor;
DE Short=TXA2-R;
DE AltName: Full=Prostanoid TP receptor;
GN Name=TBXA2R;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC TISSUE=Heart, and Liver;
RX PubMed=9561101; DOI=10.1007/978-1-4899-1810-9_8;
RA Muck S., Schroer K.;
RT "Cloning, tissue-specific expression and regulation of the bovine
RT thromboxane A2 receptor.";
RL Adv. Exp. Med. Biol. 433:47-50(1997).
CC -!- FUNCTION: Receptor for thromboxane A2 (TXA2), a potent stimulator of
CC platelet aggregation. The activity of this receptor is mediated by a G-
CC protein that activates a phosphatidylinositol-calcium second messenger
CC system. In the kidney, the binding of TXA2 to glomerular TP receptors
CC causes intense vasoconstriction. Activates phospholipase C and adenylyl
CC cyclase.
CC -!- SUBUNIT: Interacts with RPGRIP1L. Interacts with RACK1; the interaction
CC regulates TBXA2R cell surface expression (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U53485; AAC34309.1; -; Genomic_DNA.
DR EMBL; U53484; AAC34308.1; -; mRNA.
DR RefSeq; NP_001161391.1; NM_001167919.1.
DR RefSeq; XP_005209020.1; XM_005208963.3.
DR AlphaFoldDB; Q95125; -.
DR SMR; Q95125; -.
DR STRING; 9913.ENSBTAP00000019892; -.
DR PaxDb; Q95125; -.
DR PRIDE; Q95125; -.
DR Ensembl; ENSBTAT00000019892; ENSBTAP00000019892; ENSBTAG00000014944.
DR GeneID; 538783; -.
DR KEGG; bta:538783; -.
DR CTD; 6915; -.
DR VEuPathDB; HostDB:ENSBTAG00000014944; -.
DR VGNC; VGNC:35673; TBXA2R.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01030000234559; -.
DR HOGENOM; CLU_045991_3_0_1; -.
DR InParanoid; Q95125; -.
DR OMA; ASVCWMP; -.
DR OrthoDB; 972015at2759; -.
DR TreeFam; TF324982; -.
DR Reactome; R-BTA-391908; Prostanoid ligand receptors.
DR Reactome; R-BTA-416476; G alpha (q) signalling events.
DR Reactome; R-BTA-416482; G alpha (12/13) signalling events.
DR Reactome; R-BTA-428930; Thromboxane signalling through TP receptor.
DR Proteomes; UP000009136; Chromosome 7.
DR Bgee; ENSBTAG00000014944; Expressed in blood and 97 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004961; F:thromboxane A2 receptor activity; IBA:GO_Central.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0090051; P:negative regulation of cell migration involved in sprouting angiogenesis; IEA:Ensembl.
DR GO; GO:0045777; P:positive regulation of blood pressure; IBA:GO_Central.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IBA:GO_Central.
DR GO; GO:0045987; P:positive regulation of smooth muscle contraction; IEA:Ensembl.
DR GO; GO:0045907; P:positive regulation of vasoconstriction; IBA:GO_Central.
DR GO; GO:0032496; P:response to lipopolysaccharide; IEA:Ensembl.
DR GO; GO:0019932; P:second-messenger-mediated signaling; IEA:Ensembl.
DR GO; GO:0006939; P:smooth muscle contraction; IEA:Ensembl.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR008365; Prostanoid_rcpt.
DR InterPro; IPR001105; Thbox_rcpt.
DR PANTHER; PTHR11866; PTHR11866; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR01788; PROSTANOIDR.
DR PRINTS; PR00429; THROMBOXANER.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Phosphoprotein; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..343
FT /note="Thromboxane A2 receptor"
FT /id="PRO_0000070136"
FT TOPO_DOM 1..29
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 30..52
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 53..66
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 67..87
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 88..106
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 107..128
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 129..149
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 150..172
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 173..193
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..246
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 247..270
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 271..289
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 290..311
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 312..343
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT MOD_RES 329
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P21731"
FT MOD_RES 331
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P30987"
FT CARBOHYD 4
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 16
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 105..183
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 343 AA; 37841 MW; 625FBA8C341250A5 CRC64;
MWPNASSLGP CFRPMNITLE ERRLIASPWF AASFCLVGLA SNLLALSVLM GARQGSSQSR
SSFLTFLCGL VLTDFMGLLV TGAIVVTQHF VLFEWQAVDP GCSLCHFMGV IMVFFGLCPL
LLGAAMASER FLGITRPFSR PATASQRRAW TTVGLVWASA LALGLLPLLG VGHYTVQYPG
SWCFLTLGTD PGDVAFGLLF ALLGSISVGM SFLLNTISVA TLCHVYHGQA TAQQRPRDCE
VEMMVQLMGI MVVASICWMP LLVFIAQTVL QSPPAMSPTG QLSRLTERQL LIYLRVATWN
QILDPWVYIL FRRAVIQRFY PRLSTRSRSL SLQPQLTRRS TIH
