ID   TA2R_MOUSE              Reviewed;         341 AA.
AC   P30987;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   03-AUG-2022, entry version 163.
DE   RecName: Full=Thromboxane A2 receptor;
DE            Short=TXA2-R;
DE   AltName: Full=Prostanoid TP receptor;
GN   Name=Tbxa2r;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=ddY; TISSUE=Lung;
RX   PubMed=1375456; DOI=10.1016/s0006-291x(05)80009-9;
RA   Namba T., Sugimoto Y., Hirata M., Hayashi Y., Honda A., Watabe A.,
RA   Negishi M., Ichikawa A., Narumiya S.;
RT   "Mouse thromboxane A2 receptor: cDNA cloning, expression and northern blot
RT   analysis.";
RL   Biochem. Biophys. Res. Commun. 184:1197-1203(1992).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-328, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Lung, and Spleen;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Receptor for thromboxane A2 (TXA2), a potent stimulator of
CC       platelet aggregation. The activity of this receptor is mediated by a G-
CC       protein that activates a phosphatidylinositol-calcium second messenger
CC       system. In the kidney, the binding of TXA2 to glomerular TP receptors
CC       causes intense vasoconstriction. Activates phospholipase C and adenylyl
CC       cyclase.
CC   -!- SUBUNIT: Interacts with RPGRIP1L. Interacts with RACK1; the interaction
CC       regulates TBXA2R cell surface expression (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; D10849; BAA01622.1; -; mRNA.
DR   CCDS; CCDS24053.1; -.
DR   PIR; JH0606; JH0606.
DR   RefSeq; NP_001264194.1; NM_001277265.1.
DR   RefSeq; NP_033351.1; NM_009325.4.
DR   RefSeq; XP_006513523.1; XM_006513460.3.
DR   AlphaFoldDB; P30987; -.
DR   SMR; P30987; -.
DR   STRING; 10090.ENSMUSP00000100962; -.
DR   BindingDB; P30987; -.
DR   ChEMBL; CHEMBL1795181; -.
DR   DrugCentral; P30987; -.
DR   GuidetoPHARMACOLOGY; 346; -.
DR   GlyGen; P30987; 2 sites.
DR   iPTMnet; P30987; -.
DR   PhosphoSitePlus; P30987; -.
DR   jPOST; P30987; -.
DR   PaxDb; P30987; -.
DR   PRIDE; P30987; -.
DR   ProteomicsDB; 259335; -.
DR   Antibodypedia; 5899; 188 antibodies from 29 providers.
DR   DNASU; 21390; -.
DR   Ensembl; ENSMUST00000105325; ENSMUSP00000100962; ENSMUSG00000034881.
DR   Ensembl; ENSMUST00000220312; ENSMUSP00000151447; ENSMUSG00000034881.
DR   GeneID; 21390; -.
DR   KEGG; mmu:21390; -.
DR   UCSC; uc007ghg.2; mouse.
DR   CTD; 6915; -.
DR   MGI; MGI:98496; Tbxa2r.
DR   VEuPathDB; HostDB:ENSMUSG00000034881; -.
DR   eggNOG; KOG3656; Eukaryota.
DR   GeneTree; ENSGT01030000234559; -.
DR   HOGENOM; CLU_045991_3_0_1; -.
DR   InParanoid; P30987; -.
DR   OMA; ASVCWMP; -.
DR   OrthoDB; 972015at2759; -.
DR   PhylomeDB; P30987; -.
DR   TreeFam; TF324982; -.
DR   Reactome; R-MMU-391908; Prostanoid ligand receptors.
DR   Reactome; R-MMU-416476; G alpha (q) signalling events.
DR   Reactome; R-MMU-416482; G alpha (12/13) signalling events.
DR   Reactome; R-MMU-428930; Thromboxane signalling through TP receptor.
DR   BioGRID-ORCS; 21390; 4 hits in 74 CRISPR screens.
DR   PRO; PR:P30987; -.
DR   Proteomes; UP000000589; Chromosome 10.
DR   RNAct; P30987; protein.
DR   Bgee; ENSMUSG00000034881; Expressed in thymus and 83 other tissues.
DR   ExpressionAtlas; P30987; baseline and differential.
DR   Genevisible; P30987; MM.
DR   GO; GO:0001669; C:acrosomal vesicle; ISO:MGI.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016607; C:nuclear speck; ISO:MGI.
DR   GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR   GO; GO:0004961; F:thromboxane A2 receptor activity; IBA:GO_Central.
DR   GO; GO:0004960; F:thromboxane receptor activity; IDA:MGI.
DR   GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0071222; P:cellular response to lipopolysaccharide; ISO:MGI.
DR   GO; GO:0006954; P:inflammatory response; IMP:MGI.
DR   GO; GO:0090051; P:negative regulation of cell migration involved in sprouting angiogenesis; ISO:MGI.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; ISO:MGI.
DR   GO; GO:0030194; P:positive regulation of blood coagulation; ISO:MGI.
DR   GO; GO:0045777; P:positive regulation of blood pressure; ISO:MGI.
DR   GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; ISO:MGI.
DR   GO; GO:0045987; P:positive regulation of smooth muscle contraction; IDA:MGI.
DR   GO; GO:0045907; P:positive regulation of vasoconstriction; ISO:MGI.
DR   GO; GO:0019229; P:regulation of vasoconstriction; IGI:MGI.
DR   GO; GO:0045471; P:response to ethanol; IEA:Ensembl.
DR   GO; GO:0032496; P:response to lipopolysaccharide; IMP:MGI.
DR   GO; GO:0007584; P:response to nutrient; IEA:Ensembl.
DR   GO; GO:0033574; P:response to testosterone; IEA:Ensembl.
DR   GO; GO:0009410; P:response to xenobiotic stimulus; IEA:Ensembl.
DR   GO; GO:0019932; P:second-messenger-mediated signaling; IDA:MGI.
DR   GO; GO:0006939; P:smooth muscle contraction; IDA:MGI.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR008365; Prostanoid_rcpt.
DR   InterPro; IPR001105; Thbox_rcpt.
DR   PANTHER; PTHR11866; PTHR11866; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR01788; PROSTANOIDR.
DR   PRINTS; PR00429; THROMBOXANER.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Phosphoprotein; Receptor; Reference proteome; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..341
FT                   /note="Thromboxane A2 receptor"
FT                   /id="PRO_0000070139"
FT   TOPO_DOM        1..29
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        30..52
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        53..65
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        66..86
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        87..105
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        106..127
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        128..147
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        148..170
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        171..191
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        192..217
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        218..244
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        245..268
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        269..287
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        288..309
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        310..341
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         328
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
FT   CARBOHYD        4
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        16
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        104..181
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   341 AA;  37098 MW;  F090F027E7D1F234 CRC64;
     MWPNGTSLGA CFRPVNITLQ ERRAIASPWF AASFCALGLG SNLLALSVLA GARPGAGPRS
     SFLALLCGLV LTDFLGLLVT GAIVASQHAA LLDWRATDPS CRLCYFMGVA MVFFGLCPLL
     LGAAMASERF VGITRPFSRP TATSRRAWAT VGLVWVAAGA LGLLPLLGLG RYSVQYPGSW
     CFLTLGTQRG DVVFGLIFAL LGSASVGLSL LLNTVSVATL CRVYHTREAT QRPRDCEVEM
     MVQLVGIMVV ATVCWMPLLV FIMQTLLQTP PVMSFSGQLL RATEHQLLIY LRVATWNQIL
     DPWVYILFRR SVLRRLHPRF SSQLQAVSLR RPPAQAMLSG P