ID   TA4_EIMTE               Reviewed;         253 AA.
AC   P13399;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   25-MAY-2022, entry version 49.
DE   RecName: Full=Sporulated oocyst TA4 antigen;
DE   AltName: Full=Major sporozoite surface antigen;
DE   Contains:
DE     RecName: Full=Sporulated oocyst TA4 antigen 17 kDa subunit;
DE   Contains:
DE     RecName: Full=Sporulated oocyst TA4 antigen 8 kDa subunit;
DE   Flags: Precursor;
OS   Eimeria tenella (Coccidian parasite).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC   Eucoccidiorida; Eimeriorina; Eimeriidae; Eimeria.
OX   NCBI_TaxID=5802;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Files J.G., Paul L.S., Gabe J.D.;
RT   "Identification and characterization of the gene for a major surface
RT   antigen of Eimeria tenella.";
RL   (In) Agabian N., Goodman H., Noguiera N. (eds.);
RL   Molecular strategies of parasitic invasion, UCLA symposia on molecular and
RL   cellular biology, pp.713-723, Alan R. Liss, New York (1987).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 23-253, AND PARTIAL PROTEIN SEQUENCE.
RC   STRAIN=27 / Salesbury laboratory;
RX   PubMed=3290678; DOI=10.1016/0166-6851(88)90008-4;
RA   Brothers V.M., Kuhn I., Paul L.S., Gabe J.D., Andrews W.H., Sias S.R.,
RA   McCaman M.T., Dragon E.A., Files J.G.;
RT   "Characterization of a surface antigen of Eimeria tenella sporozoites and
RT   synthesis from a cloned cDNA in Escherichia coli.";
RL   Mol. Biochem. Parasitol. 28:235-248(1988).
CC   -!- SUBUNIT: The TA4 antigen is composed of a 17 kDa and a 8 kDa chain,
CC       linked by a disulfide bond.
CC   -!- SUBCELLULAR LOCATION: Note=Surface of sporozoites.
CC   -!- DEVELOPMENTAL STAGE: Expressed after initiation of oocyst sporulation.
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DR   EMBL; M21088; AAA29074.1; -; Genomic_DNA.
DR   EMBL; M21004; AAA29075.1; -; mRNA.
DR   PIR; A54501; A54501.
DR   AlphaFoldDB; P13399; -.
DR   VEuPathDB; ToxoDB:ETH2_1143600; -.
DR   VEuPathDB; ToxoDB:ETH_00010835; -.
DR   InterPro; IPR021288; Surface_antigen.
DR   Pfam; PF11054; Surface_antigen; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Signal.
FT   SIGNAL          1..23
FT   CHAIN           24..181
FT                   /note="Sporulated oocyst TA4 antigen 17 kDa subunit"
FT                   /id="PRO_0000022464"
FT   PROPEP          182..184
FT                   /note="Removed in mature form"
FT                   /id="PRO_0000022465"
FT   CHAIN           185..253
FT                   /note="Sporulated oocyst TA4 antigen 8 kDa subunit"
FT                   /id="PRO_0000022466"
SQ   SEQUENCE   253 AA;  27137 MW;  6DBDFFB4102F704E CRC64;
     MARLSFVSLL SLSLLFGQQA VRAQDYPTAV TLDCKEAMNK LRKAAGLPAF EDAVGDTFVL
     PAYSHEESRA APVAETLWKT EICPKVLGGG RSRNVTEAVK LTGNFAYYPV TDGKKECSDA
     VEYWKGGLSQ FNDTIPPTFQ ALNDPVVYND RAVSFVALYN PKTSPVVSCV LLQCPNAGVG
     GRRLAAGTTD AVICLTNPAP LEARSQPFDD EQWKKIVDSL SLSEEEEEKG GVSPVVPSVA
     LISAAVISAF ALF