TAA7A_RAT
ID TAA7A_RAT Reviewed; 358 AA.
AC Q923Y2;
DT 07-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Trace amine-associated receptor 7a;
DE Short=TaR-7a;
DE Short=Trace amine receptor 7a;
DE AltName: Full=Trace amine receptor 8;
DE Short=TaR-8;
GN Name=Taar7a; Synonyms=Ta8, Tar8, Trar8;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Sprague-Dawley;
RX PubMed=11459929; DOI=10.1073/pnas.151105198;
RA Borowsky B., Adham N., Jones K.A., Raddatz R., Artymyshyn R.,
RA Ogozalek K.L., Durkin M.M., Lakhlani P.P., Bonini J.A., Pathirana S.,
RA Boyle N., Pu X., Kouranova E., Lichtblau H., Ochoa F.Y., Branchek T.A.,
RA Gerald C.;
RT "Trace amines: identification of a family of mammalian G protein-coupled
RT receptors.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:8966-8971(2001).
CC -!- FUNCTION: Orphan receptor. Could be a receptor for trace amines. Trace
CC amines are biogenic amines present in very low levels in mammalian
CC tissues. Although some trace amines have clearly defined roles as
CC neurotransmitters in invertebrates, the extent to which they function
CC as true neurotransmitters in vertebrates has remained speculative.
CC Trace amines are likely to be involved in a variety of physiological
CC functions that have yet to be fully understood.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF380196; AAK71247.1; -; Genomic_DNA.
DR RefSeq; NP_783175.1; NM_175585.1.
DR AlphaFoldDB; Q923Y2; -.
DR SMR; Q923Y2; -.
DR GlyGen; Q923Y2; 2 sites.
DR PaxDb; Q923Y2; -.
DR Ensembl; ENSRNOT00000061221; ENSRNOP00000079118; ENSRNOG00000062468.
DR GeneID; 294125; -.
DR KEGG; rno:294125; -.
DR CTD; 215856; -.
DR RGD; 631387; Taar7a.
DR GeneTree; ENSGT00940000160273; -.
DR InParanoid; Q923Y2; -.
DR OrthoDB; 973471at2759; -.
DR PhylomeDB; Q923Y2; -.
DR PRO; PR:Q923Y2; -.
DR Proteomes; UP000002494; Chromosome 1.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001594; F:trace-amine receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR009132; TAAR_fam.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01830; TRACEAMINER.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..358
FT /note="Trace amine-associated receptor 7a"
FT /id="PRO_0000070163"
FT TOPO_DOM 1..47
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 48..68
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 69..83
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 84..104
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 105..121
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 122..143
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 144..166
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 167..187
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 188..212
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 213..233
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 234..274
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 275..295
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 296..309
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 310..333
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 334..358
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 34
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 210
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 120..205
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 358 AA; 40147 MW; E136ADA32C1A268B CRC64;
MDKLVDNFLS GQSRTMSEDL LSASSPQLCY ENLNGSCIRS PYSPGPRLIL YAVFGFGAVL
AVCGNLLVMT SILHFRQLHS PANFLVASLA CADFLVGLTV MPFSTVRSVE GCWYFGDTYC
KFHSCFEGSF CYSSIFHLCF ISVDRYIAVS DPLIYPTRFT ASVSGKCITF SWLLSIIYSF
SLLYTGANEA GLEDLVSALT CVGGCQIAVN QSWVFINFLL FLVPTLVMMT VYSKIFLIAK
QQAQNIEKMS KQTTRASESY KDRVAKRERK AAKTLGIAVA AFLLSWLPYF IDSIIDAFLG
FITPTYVYEI LVWIAYYNSA MNPLIYAFFY PWFRKAIKLI VTGKILRQNS SVTNLFPE
