TAA7B_RAT
ID TAA7B_RAT Reviewed; 358 AA.
AC Q923X8; Q5QD22;
DT 07-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 2.
DT 25-MAY-2022, entry version 121.
DE RecName: Full=Trace amine-associated receptor 7b;
DE Short=TaR-7b;
DE Short=Trace amine receptor 7b;
DE AltName: Full=Trace amine receptor 12;
DE Short=TaR-12;
GN Name=Taar7b; Synonyms=Ta12, Tar12, Trar12;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Sprague-Dawley;
RX PubMed=11459929; DOI=10.1073/pnas.151105198;
RA Borowsky B., Adham N., Jones K.A., Raddatz R., Artymyshyn R.,
RA Ogozalek K.L., Durkin M.M., Lakhlani P.P., Bonini J.A., Pathirana S.,
RA Boyle N., Pu X., Kouranova E., Lichtblau H., Ochoa F.Y., Branchek T.A.,
RA Gerald C.;
RT "Trace amines: identification of a family of mammalian G protein-coupled
RT receptors.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:8966-8971(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=WIST/Crl;
RX PubMed=15718104; DOI=10.1016/j.ygeno.2004.11.010;
RA Lindemann L., Ebeling M., Kratochwil N.A., Bunzow J.R., Grandy D.K.,
RA Hoener M.C.;
RT "Trace amine-associated receptors form structurally and functionally
RT distinct subfamilies of novel G protein-coupled receptors.";
RL Genomics 85:372-385(2005).
CC -!- FUNCTION: Orphan receptor. Could be a receptor for trace amines. Trace
CC amines are biogenic amines present in very low levels in mammalian
CC tissues. Although some trace amines have clearly defined roles as
CC neurotransmitters in invertebrates, the extent to which they function
CC as true neurotransmitters in vertebrates has remained speculative.
CC Trace amines are likely to be involved in a variety of physiological
CC functions that have yet to be fully understood.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK71251.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF380200; AAK71251.1; ALT_INIT; Genomic_DNA.
DR EMBL; AY702319; AAV70131.1; -; Genomic_DNA.
DR RefSeq; NP_783176.2; NM_175586.2.
DR AlphaFoldDB; Q923X8; -.
DR SMR; Q923X8; -.
DR STRING; 10116.ENSRNOP00000021559; -.
DR BindingDB; Q923X8; -.
DR ChEMBL; CHEMBL2176813; -.
DR GlyGen; Q923X8; 2 sites.
DR PaxDb; Q923X8; -.
DR PRIDE; Q923X8; -.
DR Ensembl; ENSRNOT00000021559; ENSRNOP00000021559; ENSRNOG00000071181.
DR GeneID; 294126; -.
DR KEGG; rno:294126; -.
DR CTD; 209517; -.
DR RGD; 631392; Taar7b.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00940000160273; -.
DR HOGENOM; CLU_009579_11_0_1; -.
DR InParanoid; Q923X8; -.
DR OMA; YEILLWI; -.
DR OrthoDB; 973471at2759; -.
DR PhylomeDB; Q923X8; -.
DR TreeFam; TF343107; -.
DR PRO; PR:Q923X8; -.
DR Proteomes; UP000002494; Chromosome 1.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001594; F:trace-amine receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR009132; TAAR_fam.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01830; TRACEAMINER.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..358
FT /note="Trace amine-associated receptor 7b"
FT /id="PRO_0000070165"
FT TOPO_DOM 1..47
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 48..68
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 69..83
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 84..104
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 105..125
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 126..147
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 148..166
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 167..187
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 188..211
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 212..232
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 233..274
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 275..295
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 296..309
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 310..332
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 333..358
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 34
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 210
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 120..205
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 358 AA; 40291 MW; B73ADC0A748F9A2F CRC64;
MATDDDRFPW DQDSILSRDL LSASSMQLCY EKLNRSCVRS PYSPGPRLIL YAVFGFGAVL
AVCGNLLVMT SILHFRQLHS PANFLVASLA CADFLVGLTV MPFSMVRSVE GCWYFGDIYC
KFHSSFDGSF CYSSIFHLCF ISADRYIAVS DPLIYPTRFT ASVSGKCITF SWLLSIIYSF
SLFYTGVNEA GLEDLVSALT CVGGCQIAVN QSWVFINFLL FLVPALVMMT VYSKIFLIAK
QQAQNIEKMG KQTARASESY KDRVAKRERK AAKTLGIAVA AFLLSWLPYF IDSIIDAFLG
FVTPTYVYEI LVWIGYYNSA MNPLIYAFFY PWFRKAIKLI VTGKILRENS SATNLFPE
