ID   TAA7C_RAT               Reviewed;         358 AA.
AC   Q5QD21;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Trace amine-associated receptor 7c;
DE            Short=TaR-7c;
DE            Short=Trace amine receptor 7c;
GN   Name=Taar7c;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=WIST/Crl;
RX   PubMed=15718104; DOI=10.1016/j.ygeno.2004.11.010;
RA   Lindemann L., Ebeling M., Kratochwil N.A., Bunzow J.R., Grandy D.K.,
RA   Hoener M.C.;
RT   "Trace amine-associated receptors form structurally and functionally
RT   distinct subfamilies of novel G protein-coupled receptors.";
RL   Genomics 85:372-385(2005).
CC   -!- FUNCTION: Orphan receptor. Could be a receptor for trace amines. Trace
CC       amines are biogenic amines present in very low levels in mammalian
CC       tissues. Although some trace amines have clearly defined roles as
CC       neurotransmitters in invertebrates, the extent to which they function
CC       as true neurotransmitters in vertebrates has remained speculative.
CC       Trace amines are likely to be involved in a variety of physiological
CC       functions that have yet to be fully understood (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AY702320; AAV70132.1; -; Genomic_DNA.
DR   RefSeq; NP_001009975.1; NM_001009975.1.
DR   AlphaFoldDB; Q5QD21; -.
DR   SMR; Q5QD21; -.
DR   STRING; 10116.ENSRNOP00000041914; -.
DR   GlyGen; Q5QD21; 1 site.
DR   PaxDb; Q5QD21; -.
DR   Ensembl; ENSRNOT00000050763; ENSRNOP00000041914; ENSRNOG00000071165.
DR   GeneID; 494535; -.
DR   KEGG; rno:494535; -.
DR   CTD; 494535; -.
DR   RGD; 1359258; Taar7c.
DR   eggNOG; KOG3656; Eukaryota.
DR   GeneTree; ENSGT00940000160273; -.
DR   HOGENOM; CLU_009579_11_0_1; -.
DR   InParanoid; Q5QD21; -.
DR   OMA; CQIAVNS; -.
DR   OrthoDB; 973471at2759; -.
DR   TreeFam; TF343107; -.
DR   PRO; PR:Q5QD21; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0001594; F:trace-amine receptor activity; IBA:GO_Central.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR009132; TAAR_fam.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR01830; TRACEAMINER.
DR   SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..358
FT                   /note="Trace amine-associated receptor 7c"
FT                   /id="PRO_0000070166"
FT   TOPO_DOM        1..47
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        48..68
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        69..83
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        84..104
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        105..125
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        126..148
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        149..166
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        167..187
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        188..211
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        212..232
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        233..274
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        275..295
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        296..309
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        310..332
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        333..358
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        34
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        120..205
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   358 AA;  40303 MW;  FA84DD12CF2C4CED CRC64;
     MATDDDSFPW DQDSILSRDL LSASSLQLCY ENLNRSCVRS PYSPGSRLIL YAVFGFGAVL
     AVCGNLLVMT SILHFRQLHS PANFLVASLA CADLLVGLTV MPFSMVRSVE GCWYFGNTYC
     KFHSCFEGSF CYSSLFHLCF ISLDRYIAVS DPLIYPTRFT ASISGKCITF SWLLSIIYSF
     SLLYTGANEA GLEDLVSALT CVGGCQVAVN QSWVFINFLL FLVPALVMMT VYSKIFLIAK
     QQAQNIEKMS KQTARASESY KDRVAKRERK AAKTLGIAVA AFLLSWLPYF IDSIIDAFLG
     FITPTYMYEI LVWIVYYNSA MNPLIYAFFY PWFRKAIKLI VTGKILRENS STINLFPE