ID   TAA7D_RAT               Reviewed;         358 AA.
AC   Q923X5;
DT   07-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Trace amine-associated receptor 7d;
DE            Short=TaR-7d;
DE            Short=Trace amine receptor 7d;
DE   AltName: Full=Trace amine receptor 15;
DE            Short=TaR-15;
GN   Name=Taar7d; Synonyms=Ta15, Tar15, Trar15;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Sprague-Dawley;
RX   PubMed=11459929; DOI=10.1073/pnas.151105198;
RA   Borowsky B., Adham N., Jones K.A., Raddatz R., Artymyshyn R.,
RA   Ogozalek K.L., Durkin M.M., Lakhlani P.P., Bonini J.A., Pathirana S.,
RA   Boyle N., Pu X., Kouranova E., Lichtblau H., Ochoa F.Y., Branchek T.A.,
RA   Gerald C.;
RT   "Trace amines: identification of a family of mammalian G protein-coupled
RT   receptors.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:8966-8971(2001).
CC   -!- FUNCTION: Orphan receptor. Could be a receptor for trace amines. Trace
CC       amines are biogenic amines present in very low levels in mammalian
CC       tissues. Although some trace amines have clearly defined roles as
CC       neurotransmitters in invertebrates, the extent to which they function
CC       as true neurotransmitters in vertebrates has remained speculative.
CC       Trace amines are likely to be involved in a variety of physiological
CC       functions that have yet to be fully understood.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AF380203; AAK71254.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q923X5; -.
DR   SMR; Q923X5; -.
DR   STRING; 10116.ENSRNOP00000049417; -.
DR   GlyGen; Q923X5; 1 site.
DR   PaxDb; Q923X5; -.
DR   RGD; 631395; Taar7d.
DR   eggNOG; KOG3656; Eukaryota.
DR   InParanoid; Q923X5; -.
DR   PhylomeDB; Q923X5; -.
DR   PRO; PR:Q923X5; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0001594; F:trace-amine receptor activity; IBA:GO_Central.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR009132; TAAR_fam.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR01830; TRACEAMINER.
DR   SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..358
FT                   /note="Trace amine-associated receptor 7d"
FT                   /id="PRO_0000070168"
FT   TOPO_DOM        1..47
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        48..68
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        69..83
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        84..104
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        105..122
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        123..143
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        144..166
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        167..187
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        188..212
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        213..233
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        234..274
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        275..295
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        296..309
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        310..333
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        334..358
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        34
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        120..205
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   358 AA;  40653 MW;  EE8B4D9219EE1171 CRC64;
     MRVDDDRFPW DQDSILSRDL LSASSLQLCY ENLNRSCVRS PYSPGPRLIL YAVFGFGAVL
     AVCGNLMVMT SILHFRQLHS PANFLVASLA CADFLVGLTV MPFSMVRSVE GCWYFGDTYC
     KLHTCFDVSF CYCSLFHLCF ISVDRYIAVS DPLIYPTRFT ASVSGKCITF SWLLSIIYGF
     PLIYTGASEA GLEDLVSALT CVGGCQIPMN QKFVLINFLL FLVPTLVMMT VYSKIFLIAR
     QQAQNIEKMR KQTARASESY KDRVCKRERK AAKTLGIAVA AFLLSWLPYF IDSIIDAFLG
     FITPTYVYEI LIWIVYYNSS MNPLIYAFFY PWFRKATKLI VTGKILRENS STINLFPE