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TAA7E_MOUSE
ID   TAA7E_MOUSE             Reviewed;         358 AA.
AC   Q5QD09;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=Trace amine-associated receptor 7e;
DE            Short=TaR-7e;
DE            Short=Trace amine receptor 7e;
DE            Short=mTaar7e;
GN   Name=Taar7e; Synonyms=Gm697;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=15718104; DOI=10.1016/j.ygeno.2004.11.010;
RA   Lindemann L., Ebeling M., Kratochwil N.A., Bunzow J.R., Grandy D.K.,
RA   Hoener M.C.;
RT   "Trace amine-associated receptors form structurally and functionally
RT   distinct subfamilies of novel G protein-coupled receptors.";
RL   Genomics 85:372-385(2005).
RN   [2]
RP   TISSUE SPECIFICITY.
RX   PubMed=16878137; DOI=10.1038/nature05066;
RA   Liberles S.D., Buck L.B.;
RT   "A second class of chemosensory receptors in the olfactory epithelium.";
RL   Nature 442:645-650(2006).
RN   [3]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=23624375; DOI=10.1038/nature12114;
RA   Dewan A., Pacifico R., Zhan R., Rinberg D., Bozza T.;
RT   "Non-redundant coding of aversive odours in the main olfactory pathway.";
RL   Nature 497:486-489(2013).
CC   -!- FUNCTION: Orphan olfactory receptor specific for trace amines.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Specifically expressed in neurons of the olfactory
CC       epithelium. {ECO:0000269|PubMed:16878137}.
CC   -!- DISRUPTION PHENOTYPE: Mice lacking Taar2, Taar3, Taar4, Taar5, Taar6,
CC       Taar7a, Taar7b, Taar7d, Taar7e, Taar7f, Taar8a, Taar8b, Taar8c and
CC       Taar9 show no visible phenotype or behavioral deficits. They however
CC       show an absence of aversion to low concentrations of amines such as 2-
CC       phenylethylamine, isopentylamine, N-methylpiperidine and cadaverine.
CC       {ECO:0000269|PubMed:23624375}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AY702335; AAV70144.1; -; Genomic_DNA.
DR   CCDS; CCDS23743.1; -.
DR   RefSeq; NP_001010835.1; NM_001010835.1.
DR   AlphaFoldDB; Q5QD09; -.
DR   SMR; Q5QD09; -.
DR   STRING; 10090.ENSMUSP00000090326; -.
DR   GlyGen; Q5QD09; 2 sites.
DR   PaxDb; Q5QD09; -.
DR   PRIDE; Q5QD09; -.
DR   Ensembl; ENSMUST00000092656; ENSMUSP00000090326; ENSMUSG00000100689.
DR   GeneID; 276742; -.
DR   KEGG; mmu:276742; -.
DR   UCSC; uc007eqm.1; mouse.
DR   CTD; 276742; -.
DR   MGI; MGI:3527445; Taar7e.
DR   VEuPathDB; HostDB:ENSMUSG00000100689; -.
DR   eggNOG; KOG3656; Eukaryota.
DR   GeneTree; ENSGT00940000160273; -.
DR   HOGENOM; CLU_009579_11_0_1; -.
DR   InParanoid; Q5QD09; -.
DR   OMA; CQVPVNQ; -.
DR   OrthoDB; 973471at2759; -.
DR   PhylomeDB; Q5QD09; -.
DR   TreeFam; TF343107; -.
DR   BioGRID-ORCS; 276742; 2 hits in 41 CRISPR screens.
DR   PRO; PR:Q5QD09; -.
DR   Proteomes; UP000000589; Chromosome 10.
DR   RNAct; Q5QD09; protein.
DR   ExpressionAtlas; Q5QD09; differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0001594; F:trace-amine receptor activity; IBA:GO_Central.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR009132; TAAR_fam.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR01830; TRACEAMINER.
DR   SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..358
FT                   /note="Trace amine-associated receptor 7e"
FT                   /id="PRO_0000070169"
FT   TOPO_DOM        1..47
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        48..68
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        69..83
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        84..104
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        105..121
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        122..143
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        144..166
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        167..187
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        188..212
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        213..233
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        234..274
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        275..295
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        296..309
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        310..333
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        334..358
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        34
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        210
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        120..205
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   358 AA;  40163 MW;  D20DCCB0B1039773 CRC64;
     MATGDDSFLW DQDSILSRDL FSATSAELCY ENLNRSCVRS PYSPGPRLIL YAVFGFGAVL
     AVCGNLLVMT SILHFRQLHS PANFLVASLA CADFLVGLTV MPFSTVRSVE GCWYFGEIYC
     KLHTCFDVSF CSSSIFHLCF ISVDRYIAVS DPLIYPTRFT ASVSNKCITF SWLLSISYGF
     SLIYTGASEA GLEDLVSALT CVGGCQLAVN QSWVFINFLL FLIPTLVMIT VYSKIFLIAK
     QQAQNIEKMS KQTARASDSY KDRVAKRERK AAKTLGIAVA AFLLSWLPYF IDSFIDAFLG
     FITPTYVYEI LVWIAYYNSA MNPLIYAFFY PWFRKAIKLT VTGKILRENS STTNLFPE
 
 
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