ID   TAA7E_RAT               Reviewed;         358 AA.
AC   Q923X6;
DT   07-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=Trace amine-associated receptor 7e;
DE            Short=TaR-7e;
DE            Short=Trace amine receptor 7e;
DE   AltName: Full=Trace amine receptor 14;
DE            Short=TaR-14;
GN   Name=Taar7e; Synonyms=Ta14, Tar14, Trar14;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Sprague-Dawley;
RX   PubMed=11459929; DOI=10.1073/pnas.151105198;
RA   Borowsky B., Adham N., Jones K.A., Raddatz R., Artymyshyn R.,
RA   Ogozalek K.L., Durkin M.M., Lakhlani P.P., Bonini J.A., Pathirana S.,
RA   Boyle N., Pu X., Kouranova E., Lichtblau H., Ochoa F.Y., Branchek T.A.,
RA   Gerald C.;
RT   "Trace amines: identification of a family of mammalian G protein-coupled
RT   receptors.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:8966-8971(2001).
CC   -!- FUNCTION: Orphan receptor. Could be a receptor for trace amines. Trace
CC       amines are biogenic amines present in very low levels in mammalian
CC       tissues. Although some trace amines have clearly defined roles as
CC       neurotransmitters in invertebrates, the extent to which they function
CC       as true neurotransmitters in vertebrates has remained speculative.
CC       Trace amines are likely to be involved in a variety of physiological
CC       functions that have yet to be fully understood.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AF380202; AAK71253.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q923X6; -.
DR   SMR; Q923X6; -.
DR   STRING; 10116.ENSRNOP00000045314; -.
DR   GlyGen; Q923X6; 2 sites.
DR   PaxDb; Q923X6; -.
DR   RGD; 631394; Taar7e.
DR   eggNOG; KOG3656; Eukaryota.
DR   InParanoid; Q923X6; -.
DR   PhylomeDB; Q923X6; -.
DR   PRO; PR:Q923X6; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0001594; F:trace-amine receptor activity; IBA:GO_Central.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR009132; TAAR_fam.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR01830; TRACEAMINER.
DR   SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..358
FT                   /note="Trace amine-associated receptor 7e"
FT                   /id="PRO_0000070170"
FT   TOPO_DOM        1..47
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        48..68
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        69..83
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        84..104
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        105..121
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        122..143
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        144..166
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        167..187
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        188..212
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        213..233
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        234..274
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        275..295
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        296..309
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        310..333
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        334..358
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        34
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        210
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        120..205
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   358 AA;  40217 MW;  516414E0EF0FDF00 CRC64;
     MATDDASFPW DQDSILSRDL LSALSSQLCY ENLNRSCIRS PYSPGPRLIL HAVFGFSAVL
     AVCGNLLVMT SILHFRQLHS PANFLVASLA CADLLVGLTV MPFSMVRSVE GCWYFGDIYC
     KFHSSFDVSF CYSSIFHLCF ISVDRYIAVS DPLIYLTRFT ASVSGKCITF SWFLSIIYSF
     SLLYTGASEA GLEDLVSALT CVGGCQLAVN QSWVFINFLL FLVPTLVMMT VYSKVFLIAK
     QQAQNIEKIG KQTARASESY KDRVAKRERK AAKTLGITVA AFLLSWLPYF IDSIIDAFLG
     FITPTYVYEI LVWIAYYNSA MNPLIYAFFY PWFRKAIKLI VTGKILRENS SATNLFPE