TAA7F_MOUSE
ID TAA7F_MOUSE Reviewed; 358 AA.
AC Q5QD08; B2RT90;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 04-JAN-2005, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Trace amine-associated receptor 7f;
DE Short=TaR-7f;
DE Short=Trace amine receptor 7f;
DE Short=mTaar7f;
GN Name=Taar7f;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=15718104; DOI=10.1016/j.ygeno.2004.11.010;
RA Lindemann L., Ebeling M., Kratochwil N.A., Bunzow J.R., Grandy D.K.,
RA Hoener M.C.;
RT "Trace amine-associated receptors form structurally and functionally
RT distinct subfamilies of novel G protein-coupled receptors.";
RL Genomics 85:372-385(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=16878137; DOI=10.1038/nature05066;
RA Liberles S.D., Buck L.B.;
RT "A second class of chemosensory receptors in the olfactory epithelium.";
RL Nature 442:645-650(2006).
RN [4]
RP DISRUPTION PHENOTYPE.
RX PubMed=23624375; DOI=10.1038/nature12114;
RA Dewan A., Pacifico R., Zhan R., Rinberg D., Bozza T.;
RT "Non-redundant coding of aversive odours in the main olfactory pathway.";
RL Nature 497:486-489(2013).
CC -!- FUNCTION: Olfactory receptor activated by trace amine N-
CC methylpiperidine. This receptor is probably mediated by the G(s)-class
CC of G-proteins which activate adenylate cyclase.
CC {ECO:0000269|PubMed:16878137}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Specifically expressed in neurons of the olfactory
CC epithelium. {ECO:0000269|PubMed:16878137}.
CC -!- DISRUPTION PHENOTYPE: Mice lacking Taar2, Taar3, Taar4, Taar5, Taar6,
CC Taar7a, Taar7b, Taar7d, Taar7e, Taar7f, Taar8a, Taar8b, Taar8c and
CC Taar9 show no visible phenotype or behavioral deficits. They however
CC show an absence of aversion to low concentrations of amines such as 2-
CC phenylethylamine, isopentylamine, N-methylpiperidine and cadaverine.
CC {ECO:0000269|PubMed:23624375}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY702336; AAV70145.1; -; Genomic_DNA.
DR EMBL; BC139175; AAI39176.1; -; mRNA.
DR EMBL; BC139176; AAI39177.1; -; mRNA.
DR CCDS; CCDS23744.1; -.
DR RefSeq; NP_001010839.1; NM_001010839.1.
DR AlphaFoldDB; Q5QD08; -.
DR SMR; Q5QD08; -.
DR STRING; 10090.ENSMUSP00000071611; -.
DR GlyGen; Q5QD08; 2 sites.
DR PaxDb; Q5QD08; -.
DR PRIDE; Q5QD08; -.
DR DNASU; 435207; -.
DR Ensembl; ENSMUST00000071691; ENSMUSP00000071611; ENSMUSG00000100950.
DR GeneID; 435207; -.
DR KEGG; mmu:435207; -.
DR UCSC; uc007eqn.1; mouse.
DR CTD; 435207; -.
DR MGI; MGI:3527447; Taar7f.
DR VEuPathDB; HostDB:ENSMUSG00000100950; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT00940000160273; -.
DR HOGENOM; CLU_009579_11_0_1; -.
DR InParanoid; Q5QD08; -.
DR OMA; ESCYKTP; -.
DR OrthoDB; 973471at2759; -.
DR PhylomeDB; Q5QD08; -.
DR TreeFam; TF343107; -.
DR BioGRID-ORCS; 435207; 2 hits in 71 CRISPR screens.
DR PRO; PR:Q5QD08; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q5QD08; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001594; F:trace-amine receptor activity; IDA:UniProtKB.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; IDA:UniProtKB.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR009132; TAAR_fam.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01830; TRACEAMINER.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..358
FT /note="Trace amine-associated receptor 7f"
FT /id="PRO_0000070171"
FT TOPO_DOM 1..47
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 48..68
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 69..83
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 84..104
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 105..121
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 122..143
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 144..166
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 167..187
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 188..212
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 213..233
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 234..274
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 275..295
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 296..309
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 310..333
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 334..358
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 34
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 210
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 120..205
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 358 AA; 40165 MW; 62DB98FDD12584D4 CRC64;
MSIADETVSW NQDSILSRDL FSATSAELCY ENLNRSCVRS PYSPGPRLIL YAVFGFGAVL
AVCGNLLVMT SILHFRQLHS PANFLVASLA CADFLVGVMV MPFSMVRSVE GCWYFGDSYC
KLHTCFDVSF CYCSLFHLCF ISVDRYIAVS DPLAYPTRFT ASVSGKCITF SWLLSISYGF
SLIYTGASEA GLEDLVSSLT CVGGCQIAVN QTWVFINFSV FLIPTLVMIT VYSKIFLIAK
QQAQNIEKMS KQTARASDSY KDRVAKRERK AAKTLGIAVA AFLLSWLPYF IDSFIDAFLG
FITPTYVYEI LVWIVYYNSA MNPLIYAFFY PWFRKAIKLT VTGKILRENS STTNLFSE
