TAA7H_RAT
ID TAA7H_RAT Reviewed; 358 AA.
AC Q923Y4;
DT 07-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Trace amine-associated receptor 7h;
DE Short=TaR-7h;
DE Short=Trace amine receptor 7h;
DE AltName: Full=Trace amine receptor 6;
DE Short=TaR-6;
GN Name=Taar7h; Synonyms=Ta6, Tar6, Trar6;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Sprague-Dawley;
RX PubMed=11459929; DOI=10.1073/pnas.151105198;
RA Borowsky B., Adham N., Jones K.A., Raddatz R., Artymyshyn R.,
RA Ogozalek K.L., Durkin M.M., Lakhlani P.P., Bonini J.A., Pathirana S.,
RA Boyle N., Pu X., Kouranova E., Lichtblau H., Ochoa F.Y., Branchek T.A.,
RA Gerald C.;
RT "Trace amines: identification of a family of mammalian G protein-coupled
RT receptors.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:8966-8971(2001).
CC -!- FUNCTION: Orphan receptor. Could be a receptor for trace amines. Trace
CC amines are biogenic amines present in very low levels in mammalian
CC tissues. Although some trace amines have clearly defined roles as
CC neurotransmitters in invertebrates, the extent to which they function
CC as true neurotransmitters in vertebrates has remained speculative.
CC Trace amines are likely to be involved in a variety of physiological
CC functions that have yet to be fully understood.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF380194; AAK71245.1; -; Genomic_DNA.
DR RefSeq; NP_783177.1; NM_175587.1.
DR AlphaFoldDB; Q923Y4; -.
DR SMR; Q923Y4; -.
DR STRING; 10116.ENSRNOP00000044226; -.
DR GlyGen; Q923Y4; 2 sites.
DR PaxDb; Q923Y4; -.
DR GeneID; 294130; -.
DR KEGG; rno:294130; -.
DR CTD; 294130; -.
DR RGD; 631385; Taar7h.
DR VEuPathDB; HostDB:ENSRNOG00000067484; -.
DR eggNOG; KOG3656; Eukaryota.
DR HOGENOM; CLU_009579_11_0_1; -.
DR InParanoid; Q923Y4; -.
DR OMA; ILEILAW; -.
DR OrthoDB; 973471at2759; -.
DR PhylomeDB; Q923Y4; -.
DR TreeFam; TF343107; -.
DR PRO; PR:Q923Y4; -.
DR Proteomes; UP000002494; Chromosome 1.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001594; F:trace-amine receptor activity; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR009132; TAAR_fam.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR01830; TRACEAMINER.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..358
FT /note="Trace amine-associated receptor 7h"
FT /id="PRO_0000070173"
FT TOPO_DOM 1..47
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 48..68
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 69..83
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 84..104
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 105..125
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 126..143
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 144..166
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 167..187
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 188..217
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 218..238
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 239..274
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 275..295
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 296..309
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 310..333
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 334..358
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 34
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 210
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 120..205
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 358 AA; 40074 MW; CAE028CF89943DCE CRC64;
MATDDESFPW DQDSILSRDL LSALSPQLCY ENLNRSCVRS PYSPGPRLIL YAVFGFGAVL
AVCGNLLVMT SILHFRQLHS PANFLVASLA CADLLVGLTV MPFSMVRSVE GCWYFGDSYC
KLHTSFDMSF CCSSLLHLCF ISVDRYIAVS DPLIYPIRFT ASVSGKCITF SWFLSIIYGF
SLIYTGASEA GLKDLVSALS CVGGCQIPMN QSCVLINFLL FLVPTLVMMT VYSKIFLIAK
QQAQNMEKMS KQTTRASDSY KDRVAKRERK AAKTLGIAVA AFLLSWLPYL IDSIIDAFLG
FITPSYVYEI LVWIVYYNSA MNPLIYAFFY PWFRNAIKLI VTGKILKQNS STTNLFSE