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TAA8A_MOUSE
ID   TAA8A_MOUSE             Reviewed;         344 AA.
AC   Q5QD07;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=Trace amine-associated receptor 8a;
DE            Short=TaR-8a;
DE            Short=Trace amine receptor 8a;
DE            Short=mTaar8a;
GN   Name=Taar8a; Synonyms=Gm230;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=15718104; DOI=10.1016/j.ygeno.2004.11.010;
RA   Lindemann L., Ebeling M., Kratochwil N.A., Bunzow J.R., Grandy D.K.,
RA   Hoener M.C.;
RT   "Trace amine-associated receptors form structurally and functionally
RT   distinct subfamilies of novel G protein-coupled receptors.";
RL   Genomics 85:372-385(2005).
RN   [2]
RP   TISSUE SPECIFICITY.
RX   PubMed=16878137; DOI=10.1038/nature05066;
RA   Liberles S.D., Buck L.B.;
RT   "A second class of chemosensory receptors in the olfactory epithelium.";
RL   Nature 442:645-650(2006).
RN   [3]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=23624375; DOI=10.1038/nature12114;
RA   Dewan A., Pacifico R., Zhan R., Rinberg D., Bozza T.;
RT   "Non-redundant coding of aversive odours in the main olfactory pathway.";
RL   Nature 497:486-489(2013).
CC   -!- FUNCTION: Orphan olfactory receptor specific for trace amines.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Specifically expressed in neurons of the olfactory
CC       epithelium. {ECO:0000269|PubMed:16878137}.
CC   -!- DISRUPTION PHENOTYPE: Mice lacking Taar2, Taar3, Taar4, Taar5, Taar6,
CC       Taar7a, Taar7b, Taar7d, Taar7e, Taar7f, Taar8a, Taar8b, Taar8c and
CC       Taar9 show no visible phenotype or behavioral deficits. They however
CC       show an absence of aversion to low concentrations of amines such as 2-
CC       phenylethylamine, isopentylamine, N-methylpiperidine and cadaverine.
CC       {ECO:0000269|PubMed:23624375}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR   EMBL; AY702337; AAV70146.1; -; Genomic_DNA.
DR   CCDS; CCDS23745.1; -.
DR   RefSeq; NP_001010830.1; NM_001010830.1.
DR   AlphaFoldDB; Q5QD07; -.
DR   SMR; Q5QD07; -.
DR   STRING; 10090.ENSMUSP00000062719; -.
DR   GlyGen; Q5QD07; 2 sites.
DR   PaxDb; Q5QD07; -.
DR   PRIDE; Q5QD07; -.
DR   DNASU; 215859; -.
DR   Ensembl; ENSMUST00000051133; ENSMUSP00000062719; ENSMUSG00000096442.
DR   GeneID; 215859; -.
DR   KEGG; mmu:215859; -.
DR   UCSC; uc007eqo.1; mouse.
DR   CTD; 215859; -.
DR   MGI; MGI:2685076; Taar8a.
DR   VEuPathDB; HostDB:ENSMUSG00000096442; -.
DR   eggNOG; KOG3656; Eukaryota.
DR   GeneTree; ENSGT00940000161306; -.
DR   HOGENOM; CLU_009579_11_0_1; -.
DR   InParanoid; Q5QD07; -.
DR   OMA; DTAFCYS; -.
DR   OrthoDB; 995146at2759; -.
DR   PhylomeDB; Q5QD07; -.
DR   TreeFam; TF343107; -.
DR   BioGRID-ORCS; 215859; 3 hits in 39 CRISPR screens.
DR   PRO; PR:Q5QD07; -.
DR   Proteomes; UP000000589; Chromosome 10.
DR   RNAct; Q5QD07; protein.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0001594; F:trace-amine receptor activity; IBA:GO_Central.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR009132; TAAR_fam.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR01830; TRACEAMINER.
DR   SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..344
FT                   /note="Trace amine-associated receptor 8a"
FT                   /id="PRO_0000070175"
FT   TOPO_DOM        1..31
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        32..52
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        53..67
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        68..88
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        89..111
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        112..132
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        133..146
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        147..167
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        168..195
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        196..216
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        217..260
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        261..281
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        282
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        283..303
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        304..344
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        4
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        18
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        104..189
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   344 AA;  37848 MW;  F1A94890116107CA CRC64;
     MTSNFSQPAL QLCYENTNGS CIKTPYSPGP RVILYMVYGF GAVLAVCGNL LVVISVLHFK
     QLHSPANFLI ASLASADFLV GISVMPFSMV RSIESCWYFG DAFCSLHSCC DVAFCYSSVL
     HLCFISVDRY IAVTDPLVYP TKFTVSVSGI CISISWILPL VYSSAVFYTG ISAKGIESLV
     SALNCVGGCQ IVINQDFVLI SFLLFFIPTL VMIILYSKIF LVAKQQAVKI ETSVSGNRGE
     SSSESHKARV AKRERKAAKT LGVTVVAFMV SWLPYTIDAL VDAFMGFITP AYVYEICCWG
     TYYNSAMNPL IYAFFFPWFK KAIKLILSGE ILKGHSSTAN LFSE
 
 
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